TURAN and EVAN mediate pollen tube reception in Arabidopsis Synergids through protein glycosylation.

abstract：:Protein modifications play a major role for most biological processes in living organisms. Amino-terminal acetylation of proteins is a common modification found throughout the tree of life: the N-terminus of a nascent polypeptide chain becomes co-translationally acetylated, often after the removal of the initiating me...

journal_title：PLoS biology

authors： Goetze S,Qeli E,Mosimann C,Staes A,Gerrits B,Roschitzki B,Mohanty S,Niederer EM,Laczko E,Timmerman E,Lange V,Hafen E,Aebersold R,Vandekerckhove J,Basler K,Ahrens CH,Gevaert K,Brunner E

更新日期：2009-11-01 00:00:00

abstract：:The prospects for the success of malaria control depend, in part, on the basic reproductive number for malaria, R0. Here, we estimate R0 in a novel way for 121 African populations, and thereby increase the number of R0 estimates for malaria by an order of magnitude. The estimates range from around one to more than 3,0...

journal_title：PLoS biology

authors： Smith DL,McKenzie FE,Snow RW,Hay SI

更新日期：2007-03-01 00:00:00

abstract：:Performance-based pay schemes in many organizations share the fundamental assumption that the performance level for a given task will increase as a function of the amount of incentive provided. Consistent with this notion, psychological studies have demonstrated that expectations of reward can improve performance on a...

journal_title：PLoS biology

authors： Liljeholm M,O'Doherty JP

更新日期：2012-02-01 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally...

journal_title：PLoS biology

authors： Duveau F,Félix MA

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:While multiple studies have reported the accelerated evolution of brain gene expression in the human lineage, the mechanisms underlying such changes are unknown. Here, we address this issue from a developmental perspective, by analyzing mRNA and microRNA (miRNA) expression in two brain regions within macaques, chimpan...

journal_title：PLoS biology

authors： Somel M,Liu X,Tang L,Yan Z,Hu H,Guo S,Jiang X,Zhang X,Xu G,Xie G,Li N,Hu Y,Chen W,Pääbo S,Khaitovich P

更新日期：2011-12-01 00:00:00

abstract：:A lysosomal storage disease (LSD) results from deficient lysosomal enzyme activity, thus the substrate of the mutant enzyme accumulates in the lysosome, leading to pathology. In many but not all LSDs, the clinically most important mutations compromise the cellular folding of the enzyme, subjecting it to endoplasmic re...

journal_title：PLoS biology

authors： Mu TW,Fowler DM,Kelly JW

更新日期：2008-02-01 00:00:00

abstract：:A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...

journal_title：PLoS biology

authors： Bahramisharif A,Jensen O,Jacobs J,Lisman J

更新日期：2018-08-15 00:00:00

abstract：:The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent progress in unraveling the role of STIM2 in Ca2+ signaling, the mechan...

journal_title：PLoS biology

authors： Zheng S,Ma G,He L,Zhang T,Li J,Yuan X,Nguyen NT,Huang Y,Zhang X,Gao P,Nwokonko R,Gill DL,Dong H,Zhou Y,Wang Y

更新日期：2018-11-16 00:00:00

abstract：:A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the...

journal_title：PLoS biology

authors： Landgraf C,Panni S,Montecchi-Palazzi L,Castagnoli L,Schneider-Mergener J,Volkmer-Engert R,Cesareni G

更新日期：2004-01-01 00:00:00

abstract：:Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeni...

journal_title：PLoS biology

authors： Butts DA,Kanold PO,Shatz CJ

更新日期：2007-03-01 00:00:00

abstract：:Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...

journal_title：PLoS biology

authors： Knapp BD,Zhu L,Huang KC

更新日期：2020-11-06 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...

journal_title：PLoS biology

authors： Poczai P,Bell N,Hyvönen J

更新日期：2014-01-01 00:00:00

abstract：:Over the past 3 decades, in a series of studies on some of the most extensively studied toxic chemicals and pollutants, scientists have found that the amount of toxic chemical linked with the development of a disease or death-which is central to determining "safe" or "hazardous" levels-is proportionately greater at th...

journal_title：PLoS biology

authors： Lanphear BP

更新日期：2017-12-19 00:00:00

abstract：:Mycobacterium tuberculosis infects one third of the human world population and kills someone every 15 seconds. For more than a century, scientists and clinicians have been distinguishing between the human- and animal-adapted members of the M. tuberculosis complex (MTBC). However, all human-adapted strains of MTBC have...

journal_title：PLoS biology

authors： Hershberg R,Lipatov M,Small PM,Sheffer H,Niemann S,Homolka S,Roach JC,Kremer K,Petrov DA,Feldman MW,Gagneux S

更新日期：2008-12-16 00:00:00

abstract：:The significance of symbioses between eukaryotic hosts and microbes extends from the organismal to the ecosystem level and underpins the health of Earth's most threatened marine ecosystems. Despite rapid growth in research on host-associated microbes, from individual microbial symbionts to host-associated consortia of...

journal_title：PLoS biology

authors： Wilkins LGE,Leray M,O'Dea A,Yuen B,Peixoto RS,Pereira TJ,Bik HM,Coil DA,Duffy JE,Herre EA,Lessios HA,Lucey NM,Mejia LC,Rasher DB,Sharp KH,Sogin EM,Thacker RW,Vega Thurber R,Wcislo WT,Wilbanks EG,Eisen JA

更新日期：2019-11-11 00:00:00

abstract：:Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that these enzymes can also bind polyadenylated RNAs. Here, we explored the mRNA repertoire bound by several yeast aaRSs. RNA immunoprecipitation (RIP)...

journal_title：PLoS biology

authors： Levi O,Arava Y

更新日期：2019-05-17 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular protein homeostasis. Here, we demonstrat...

journal_title：PLoS biology

authors： Ryu SW,Stewart R,Pectol DC,Ender NA,Wimalarathne O,Lee JH,Zanini CP,Harvey A,Huibregtse JM,Mueller P,Paull TT

更新日期：2020-07-20 00:00:00

abstract：:To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...

journal_title：PLoS biology

authors： Wolfe BA,Takaki T,Petronczki M,Glotzer M

更新日期：2009-05-05 00:00:00

abstract：:Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell ...

journal_title：PLoS biology

authors： Hatzold J,Conradt B

更新日期：2008-04-08 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...

journal_title：PLoS biology

authors： Ale-Agha N,Goy C,Jakobs P,Spyridopoulos I,Gonnissen S,Dyballa-Rukes N,Aufenvenne K,von Ameln F,Zurek M,Spannbrucker T,Eckermann O,Jakob S,Gorressen S,Abrams M,Grandoch M,Fischer JW,Köhrer K,Deenen R,Unfried K,Altsch

更新日期：2018-06-21 00:00:00

abstract：:In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...

journal_title：PLoS biology

authors： Palazzo AF,Springer M,Shibata Y,Lee CS,Dias AP,Rapoport TA

更新日期：2007-12-01 00:00:00

abstract：:Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...

journal_title：PLoS biology

authors： Ayres JS,Schneider DS

更新日期：2008-12-09 00:00:00

abstract：:In an age of free international shipments of mail-ordered seeds and plants, more policing will not stop the global migration of hitchhiking pests. The solution is in a preemptive response based on an internationally coordinated genomic deployment of global biodiversity in the largest breeding project since the "Garden...

journal_title：PLoS biology

authors： Zamir D

更新日期：2016-04-19 00:00:00

abstract：:The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep dep...

journal_title：PLoS biology

authors： Porrino LJ,Daunais JB,Rogers GA,Hampson RE,Deadwyler SA

更新日期：2005-09-01 00:00:00

abstract：:Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

journal_title：PLoS biology

authors： Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

更新日期：2008-12-23 00:00:00

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00