Revisiting the basic reproductive number for malaria and its implications for malaria control.

abstract：:Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...

journal_title：PLoS biology

authors： Hock K,Wolff NH,Ortiz JC,Condie SA,Anthony KRN,Blackwell PG,Mumby PJ

更新日期：2017-11-28 00:00:00

abstract：:Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...

journal_title：PLoS biology

authors： Hoehl S,Markova G

更新日期：2018-12-13 00:00:00

abstract：:The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental d...

journal_title：PLoS biology

authors： Favaro PD,Huang X,Hosang L,Stodieck S,Cui L,Liu YZ,Engelhardt KA,Schmitz F,Dong Y,Löwel S,Schlüter OM

更新日期：2018-12-26 00:00:00

abstract：:The ability of cells to accurately control gene expression levels in response to extracellular cues is limited by the inherently stochastic nature of transcriptional regulation. A change in transcription factor (TF) activity results in changes in the expression of its targets, but the way in which cell-to-cell variabi...

journal_title：PLoS biology

authors： Carey LB,van Dijk D,Sloot PM,Kaandorp JA,Segal E

更新日期：2013-01-01 00:00:00

abstract：:Apoptotic cells in animals are engulfed by phagocytic cells and subsequently degraded inside phagosomes. To study the mechanisms controlling the degradation of apoptotic cells, we developed time-lapse imaging protocols in developing Caenorhabditis elegans embryos and established the temporal order of multiple events d...

journal_title：PLoS biology

authors： Yu X,Lu N,Zhou Z

更新日期：2008-03-18 00:00:00

abstract：:Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient o...

journal_title：PLoS biology

authors： Chen Y,Keskin D,Sugimoto H,Kanasaki K,Phillips PE,Bizarro L,Sharpe A,LeBleu VS,Kalluri R

更新日期：2018-12-28 00:00:00

abstract：:In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targ...

journal_title：PLoS biology

authors： Lewis TL Jr,Mao T,Arnold DB

更新日期：2011-03-01 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Using DNA sequences 5' to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans. This effort encompasses about 10% of all genes identified in this organism. GFP-expre...

journal_title：PLoS biology

authors： Hunt-Newbury R,Viveiros R,Johnsen R,Mah A,Anastas D,Fang L,Halfnight E,Lee D,Lin J,Lorch A,McKay S,Okada HM,Pan J,Schulz AK,Tu D,Wong K,Zhao Z,Alexeyenko A,Burglin T,Sonnhammer E,Schnabel R,Jones SJ,Marra MA,

更新日期：2007-09-01 00:00:00

abstract：:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits. ...

journal_title：PLoS biology

authors： Richardson LA

更新日期：2018-10-04 00:00:00

abstract：:In fungi, mating between partners depends on the molecular recognition of two peptidyl mating pheromones by their respective receptors. The fission yeast Schizosaccharomyces pombe (Sp) has two mating types, Plus (P) and Minus (M). The mating pheromones P-factor and M-factor, secreted by P and M cells, are recognized b...

journal_title：PLoS biology

authors： Seike T,Shimoda C,Niki H

更新日期：2019-01-22 00:00:00

abstract：:To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...

journal_title：PLoS biology

authors： Wolfe BA,Takaki T,Petronczki M,Glotzer M

更新日期：2009-05-05 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...

journal_title：PLoS biology

authors： Zhang X,Alexander N,Leonardi I,Mason C,Kirkman LA,Deitsch KW

更新日期：2019-05-13 00:00:00

abstract：:Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...

journal_title：PLoS biology

authors： Wang S,Jiang B,Zhang T,Liu L,Wang Y,Wang Y,Chen X,Lin H,Zhou L,Xia Y,Chen L,Yang C,Xiong Y,Ye D,Guan KL

更新日期：2015-09-10 00:00:00

abstract：:Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...

journal_title：PLoS biology

authors： Hernandez-Sanchez W,Huang W,Plucinsky B,Garcia-Vazquez N,Robinson NJ,Schiemann WP,Berdis AJ,Skordalakes E,Taylor DJ

更新日期：2019-04-05 00:00:00

abstract：:Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine...

journal_title：PLoS biology

authors： Geissmann Q,Garcia Rodriguez L,Beckwith EJ,French AS,Jamasb AR,Gilestro GF

更新日期：2017-10-19 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...

journal_title：PLoS biology

authors： Morlon H,Potts MD,Plotkin JB

更新日期：2010-09-28 00:00:00

abstract：:While the timing of neuronal activity in the olfactory bulb (OB) relative to sniffing has been the object of many studies, the behavioral relevance of timing information generated by patterned activation within the bulbar response has not been explored. Here we show, using sniff-triggered, dynamic, 2-D, optogenetic st...

journal_title：PLoS biology

authors： Rebello MR,McTavish TS,Willhite DC,Short SM,Shepherd GM,Verhagen JV

更新日期：2014-12-16 00:00:00

abstract：:Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...

journal_title：PLoS biology

authors： Hayashi MJ,Ditye T,Harada T,Hashiguchi M,Sadato N,Carlson S,Walsh V,Kanai R

更新日期：2015-09-17 00:00:00

abstract：:The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

journal_title：PLoS biology

authors： Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

更新日期：2013-01-01 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of these transient entry intermediates has proven challenging. Here, we fine-mapped the...

journal_title：PLoS biology

authors： Ivan B,Sun Z,Subbaraman H,Friedrich N,Trkola A

更新日期：2019-01-16 00:00:00

abstract：:The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...

journal_title：PLoS biology

authors： Herzig Y,Sharpe HJ,Elbaz Y,Munro S,Schuldiner M

更新日期：2012-01-01 00:00:00

abstract：:The mechanism by which a complex auditory scene is parsed into coherent objects depends on poorly understood interactions between task-driven and stimulus-driven attentional processes. We illuminate these interactions in a simultaneous behavioral-neurophysiological study in which we manipulate participants' attention ...

journal_title：PLoS biology

authors： Elhilali M,Xiang J,Shamma SA,Simon JZ

更新日期：2009-06-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...

journal_title：PLoS biology

authors： Lu W,Hu Y,Chen G,Chen Z,Zhang H,Wang F,Feng L,Pelicano H,Wang H,Keating MJ,Liu J,McKeehan W,Wang H,Luo Y,Huang P

更新日期：2017-12-11 00:00:00

abstract：:Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

journal_title：PLoS biology

authors： Varshney RK,Terauchi R,McCouch SR

更新日期：2014-06-10 00:00:00

abstract：:Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic g...

journal_title：PLoS biology

authors： Levy SF,Ziv N,Siegal ML

更新日期：2012-01-01 00:00:00