CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity.

abstract：:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

journal_title：PLoS biology

authors： Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

更新日期：2021-01-04 00:00:00

abstract：:The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to adiponectin recepto...

journal_title：PLoS biology

authors： Nader N,Dib M,Hodeify R,Courjaret R,Elmi A,Hammad AS,Dey R,Huang XY,Machaca K

更新日期：2020-11-02 00:00:00

abstract：:Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluc...

journal_title：PLoS biology

authors： Frank SA,Rosner MR

更新日期：2012-01-01 00:00:00

abstract：:Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this function...

journal_title：PLoS biology

authors： Kushnareva Y,Andreyev AY,Kuwana T,Newmeyer DD

更新日期：2012-01-01 00:00:00

abstract：:Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular...

journal_title：PLoS biology

authors： Calleja V,Laguerre M,Parker PJ,Larijani B

更新日期：2009-01-20 00:00:00

abstract：:Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...

journal_title：PLoS biology

authors： Barbeito-Andrés J,Schuler-Faccini L,Garcez PP

更新日期：2018-08-24 00:00:00

abstract：:Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...

journal_title：PLoS biology

authors： Maletic-Savatic M

更新日期：2017-05-15 00:00:00

abstract：:The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...

journal_title：PLoS biology

authors： El-Athman R,Genov NN,Mazuch J,Zhang K,Yu Y,Fuhr L,Abreu M,Li Y,Wallach T,Kramer A,Schmitt CA,Relógio A

更新日期：2017-12-07 00:00:00

abstract：:Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...

journal_title：PLoS biology

authors： Grent-'t-Jong T,Woldorff MG

更新日期：2007-01-01 00:00:00

abstract：:Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the ...

journal_title：PLoS biology

authors： Rujano MA,Bosveld F,Salomons FA,Dijk F,van Waarde MA,van der Want JJ,de Vos RA,Brunt ER,Sibon OC,Kampinga HH

更新日期：2006-12-01 00:00:00

abstract：:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...

journal_title：PLoS biology

authors： Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CT

更新日期：2019-12-09 00:00:00

abstract：:Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may...

journal_title：PLoS biology

authors： Bergmann S,Sandler O,Sberro H,Shnider S,Schejter E,Shilo BZ,Barkai N

更新日期：2007-02-01 00:00:00

abstract：:The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation. To deepen our knowledge of cellular transcription, we have determined the structure of the 13-subunit DNA-directed RNAP from Sulfol...

journal_title：PLoS biology

authors： Korkhin Y,Unligil UM,Littlefield O,Nelson PJ,Stuart DI,Sigler PB,Bell SD,Abrescia NG

更新日期：2009-05-01 00:00:00

abstract：:Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

journal_title：PLoS biology

authors： Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

更新日期：2019-02-04 00:00:00

abstract：:Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approxi...

journal_title：PLoS biology

authors： Freedman LP,Cockburn IM,Simcoe TS

更新日期：2015-06-09 00:00:00

abstract：:The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...

journal_title：PLoS biology

authors： Kalinovsky A,Boukhtouche F,Blazeski R,Bornmann C,Suzuki N,Mason CA,Scheiffele P

更新日期：2011-02-08 00:00:00

abstract：:Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in neural coding and modulates information transfer between cortic...

journal_title：PLoS biology

authors： Lowet E,Gips B,Roberts MJ,De Weerd P,Jensen O,van der Eerden J

更新日期：2018-05-31 00:00:00

abstract：:The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...

journal_title：PLoS biology

authors： Harmon B,Sedat J

更新日期：2005-03-01 00:00:00

abstract：:After mitosis, mammalian chromosomes partially decondense to occupy distinct territories in the cell nucleus. Current models propose that territories are separated by an interchromatin domain, rich in soluble nuclear machinery, where only rare interchromosomal interactions can occur via extended chromatin loops. In co...

journal_title：PLoS biology

authors： Branco MR,Pombo A

更新日期：2006-05-01 00:00:00

abstract：:Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To s...

journal_title：PLoS biology

authors： Jeong JH,Lee DK,Liu SM,Chua SC Jr,Schwartz GJ,Jo YH

更新日期：2018-04-24 00:00:00

abstract：:Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However,...

journal_title：PLoS biology

authors： Thorburn A

更新日期：2014-10-14 00:00:00

abstract：:Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

journal_title：PLoS biology

authors： Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

更新日期：2006-05-01 00:00:00

abstract：:DEAD-box proteins are ubiquitous regulators of RNA biology. While commonly dubbed "helicases," their activities also include duplex annealing, adenosine triphosphate (ATP)-dependent RNA binding, and RNA-protein complex remodeling. Rok1, an essential DEAD-box protein, and its cofactor Rrp5 are required for ribosome ass...

journal_title：PLoS biology

authors： Khoshnevis S,Askenasy I,Johnson MC,Dattolo MD,Young-Erdos CL,Stroupe ME,Karbstein K

更新日期：2016-06-09 00:00:00

abstract：:The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

journal_title：PLoS biology

authors： Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

更新日期：2013-01-01 00:00:00

abstract：:Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...

journal_title：PLoS biology

authors： Yoshii T,Ahmad M,Helfrich-Förster C

更新日期：2009-04-07 00:00:00

abstract：:In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown. ...

journal_title：PLoS biology

authors： Stoeger T,Gerlach M,Morimoto RI,Amaral LAN

更新日期：2018-12-11 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:The organization and the mechanisms of condensation of mitotic chromosomes remain unsolved despite many decades of efforts. The lack of resolution, tight compaction, and the absence of function-specific chromatin labels have been the key technical obstacles. The correlation between DNA sequence composition and its con...

journal_title：PLoS biology

authors： Strukov YG,Sural TH,Kuroda MI,Sedat JW

更新日期：2011-01-11 00:00:00

abstract：:Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

journal_title：PLoS biology

authors： McAfee A,Pettis JS,Tarpy DR,Foster LJ

更新日期：2019-05-06 00:00:00

abstract：:CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...

journal_title：PLoS biology

authors： McQuin C,Goodman A,Chernyshev V,Kamentsky L,Cimini BA,Karhohs KW,Doan M,Ding L,Rafelski SM,Thirstrup D,Wiegraebe W,Singh S,Becker T,Caicedo JC,Carpenter AE

更新日期：2018-07-03 00:00:00