Abstract:
:Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may precede the convergence of the gradient to its steady state. Here we consider the implications of pre-steady-state decoding of the Bicoid morphogen gradient for patterning of the anterior-posterior axis of the Drosophila embryo. Quantitative analysis of the shift in the expression domains of several Bicoid targets (gap genes) upon alteration of bcd dosage, as well as a temporal analysis of a reporter for Bicoid activity, suggest that a transient decoding mechanism is employed in this setting. We show that decoding the pre-steady-state morphogen profile can reduce patterning errors caused by fluctuations in the rate of morphogen production. This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Bergmann S,Sandler O,Sberro H,Shnider S,Schejter E,Shilo BZ,Barkai Ndoi
10.1371/journal.pbio.0050046subject
Has Abstractpub_date
2007-02-01 00:00:00pages
e46issue
2eissn
1544-9173issn
1545-7885pii
06-PLBI-RA-1783R2journal_volume
5pub_type
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