How Salmonella survives the macrophage's acid attack.

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice ...

journal_title：PLoS biology

authors： Portera-Cailliau C,Weimer RM,De Paola V,Caroni P,Svoboda K

更新日期：2005-08-01 00:00:00

abstract：:Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...

journal_title：PLoS biology

authors： Wang S,Jiang B,Zhang T,Liu L,Wang Y,Wang Y,Chen X,Lin H,Zhou L,Xia Y,Chen L,Yang C,Xiong Y,Ye D,Guan KL

更新日期：2015-09-10 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00

abstract：:Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

journal_title：PLoS biology

authors： Denk W,Horstmann H

更新日期：2004-11-01 00:00:00

abstract：:Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with,...

journal_title：PLoS biology

authors： Prendergast L,van Vuuren C,Kaczmarczyk A,Doering V,Hellwig D,Quinn N,Hoischen C,Diekmann S,Sullivan KF

更新日期：2011-06-01 00:00:00

abstract：:Synaptic plasticity is widely believed to constitute a key mechanism for modifying functional properties of neuronal networks. This belief implicitly implies, however, that synapses, when not driven to change their characteristics by physiologically relevant stimuli, will maintain these characteristics over time. How ...

journal_title：PLoS biology

authors： Minerbi A,Kahana R,Goldfeld L,Kaufman M,Marom S,Ziv NE

更新日期：2009-06-23 00:00:00

abstract：:Every year, ovarian cancer kills approximately 14,000 women in the United States and more than 140,000 women worldwide. Most of these deaths are caused by tumors of the serous histological type, which is rarely diagnosed before it has disseminated. By deep paired-end sequencing of mRNA from serous ovarian cancers, fol...

journal_title：PLoS biology

authors： Salzman J,Marinelli RJ,Wang PL,Green AE,Nielsen JS,Nelson BH,Drescher CW,Brown PO

更新日期：2011-09-01 00:00:00

abstract：:The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo sup...

journal_title：PLoS biology

authors： Braitsch CM,Azizoglu DB,Htike Y,Barlow HR,Schnell U,Chaney CP,Carroll TJ,Stanger BZ,Cleaver O

更新日期：2019-07-19 00:00:00

abstract：:A recent report by the Institute of Medicine leaves few urgent reasons standing for the continued use of chimpanzees in biomedical research. It is high time to think about their retirement, Frans de Waal argues, without neglecting prospects for non-invasive research on behavior, cognition, and genetics. ...

journal_title：PLoS biology

authors： de Waal FB

更新日期：2012-01-01 00:00:00

abstract：:The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a phase of massive growth and concomitant patterning during larval s...

journal_title：PLoS biology

authors： Hamaratoglu F,de Lachapelle AM,Pyrowolakis G,Bergmann S,Affolter M

更新日期：2011-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2001951.]. ...

journal_title：PLoS biology

authors： Di Biase S,Shim HS,Kim KH,Vinciguerra M,Rappa F,Wei M,Brandhorst S,Cappello F,Mirzaei H,Lee C,Longo VD

更新日期：2017-05-01 00:00:00

abstract：:In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantage. The resulting frequency-dependent selection can structure parasite populations into strains of limited genetic overlap. For the causative agent of malaria, Plasmodium falciparum, the hig...

journal_title：PLoS biology

authors： Pilosof S,He Q,Tiedje KE,Ruybal-Pesántez S,Day KP,Pascual M

更新日期：2019-06-24 00:00:00

abstract：:In fungi, mating between partners depends on the molecular recognition of two peptidyl mating pheromones by their respective receptors. The fission yeast Schizosaccharomyces pombe (Sp) has two mating types, Plus (P) and Minus (M). The mating pheromones P-factor and M-factor, secreted by P and M cells, are recognized b...

journal_title：PLoS biology

authors： Seike T,Shimoda C,Niki H

更新日期：2019-01-22 00:00:00

abstract：:Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling ...

journal_title：PLoS biology

authors： Lau KS,Cortez-Retamozo V,Philips SR,Pittet MJ,Lauffenburger DA,Haigis KM

更新日期：2012-01-01 00:00:00

abstract：:Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a method that exploits ...

journal_title：PLoS biology

authors： Kallimasioti-Pazi EM,Thelakkad Chathoth K,Taylor GC,Meynert A,Ballinger T,Kelder MJE,Lalevée S,Sanli I,Feil R,Wood AJ

更新日期：2018-12-12 00:00:00

abstract：:The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex pl...

journal_title：PLoS biology

authors： Moon BS,Yun HM,Chang WH,Steele BH,Cai M,Choi SH,Lu W

更新日期：2017-05-03 00:00:00

abstract：:The issue of nonreplicable evidence has attracted considerable attention across biomedical and other sciences. This concern is accompanied by an increasing interest in reforming research incentives and practices. How to optimally perform these reforms is a scientific problem in itself, and economics has several scient...

journal_title：PLoS biology

authors： Gall T,Ioannidis JPA,Maniadis Z

更新日期：2017-04-26 00:00:00

abstract：:Temporarily holding information in mind is an important part of many cognitive processes, such as reasoning and language. The amount of information that can be actively held "in mind" at any time is greatly limited-research suggests that we can only actively hold three or four pieces of information at once. A central ...

journal_title：PLoS biology

authors： Hakim N,Vogel EK

更新日期：2018-08-29 00:00:00

abstract：:During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of these transient entry intermediates has proven challenging. Here, we fine-mapped the...

journal_title：PLoS biology

authors： Ivan B,Sun Z,Subbaraman H,Friedrich N,Trkola A

更新日期：2019-01-16 00:00:00

abstract：:Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats. Here, we report that Drosophila larvae exhibit a novel appetitive feeding behavio...

journal_title：PLoS biology

authors： Mishra D,Thorne N,Miyamoto C,Jagge C,Amrein H

更新日期：2018-08-07 00:00:00

abstract：:Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...

journal_title：PLoS biology

authors： Arnoldini M,Vizcarra IA,Peña-Miller R,Stocker N,Diard M,Vogel V,Beardmore RE,Hardt WD,Ackermann M

更新日期：2014-08-19 00:00:00

abstract：:The significance of symbioses between eukaryotic hosts and microbes extends from the organismal to the ecosystem level and underpins the health of Earth's most threatened marine ecosystems. Despite rapid growth in research on host-associated microbes, from individual microbial symbionts to host-associated consortia of...

journal_title：PLoS biology

authors： Wilkins LGE,Leray M,O'Dea A,Yuen B,Peixoto RS,Pereira TJ,Bik HM,Coil DA,Duffy JE,Herre EA,Lessios HA,Lucey NM,Mejia LC,Rasher DB,Sharp KH,Sogin EM,Thacker RW,Vega Thurber R,Wcislo WT,Wilbanks EG,Eisen JA

更新日期：2019-11-11 00:00:00

abstract：:We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...

journal_title：PLoS biology

authors： Ale-Agha N,Goy C,Jakobs P,Spyridopoulos I,Gonnissen S,Dyballa-Rukes N,Aufenvenne K,von Ameln F,Zurek M,Spannbrucker T,Eckermann O,Jakob S,Gorressen S,Abrams M,Grandoch M,Fischer JW,Köhrer K,Deenen R,Unfried K,Altsch

更新日期：2018-06-21 00:00:00

abstract：:The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to adiponectin recepto...

journal_title：PLoS biology

authors： Nader N,Dib M,Hodeify R,Courjaret R,Elmi A,Hammad AS,Dey R,Huang XY,Machaca K

更新日期：2020-11-02 00:00:00

abstract：:Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

journal_title：PLoS biology

authors： Varshney RK,Terauchi R,McCouch SR

更新日期：2014-06-10 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...

journal_title：PLoS biology

authors： Herzig Y,Sharpe HJ,Elbaz Y,Munro S,Schuldiner M

更新日期：2012-01-01 00:00:00

abstract：:Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that these enzymes can also bind polyadenylated RNAs. Here, we explored the mRNA repertoire bound by several yeast aaRSs. RNA immunoprecipitation (RIP)...

journal_title：PLoS biology

authors： Levi O,Arava Y

更新日期：2019-05-17 00:00:00

abstract：:Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in ...

journal_title：PLoS biology

authors： Lieberman RL

更新日期：2019-04-22 00:00:00