Abstract:
:Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in myocilin likely lead to disease, but unlocking myocilin's biological function is still an elusive goalpost. Is normal myocilin unimportant in the human body? Are scientists using the wrong methods to study myocilin biology? Here, I discuss my scientific journey into understanding one small part of the fascinating organ that is the eye.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Lieberman RLdoi
10.1371/journal.pbio.3000237subject
Has Abstractpub_date
2019-04-22 00:00:00pages
e3000237issue
4eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-18-01565journal_volume
17pub_type
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