Abstract:
:Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinematics (5-20-ms time scale) and mean speed (150-ms time scale). Rats appeared to use the integrated feature, mean speed, to guide discrimination in this task, consistent with similar prior studies. Despite this, 52% of S1 units, including 73% of units in L4 and L2/3, encoded sequences at fast time scales (≤20 ms, mostly 5-10 ms), accurately reflecting single impulse kinematics. 17% of units, mostly in L5, showed weaker impulse responses and a slow firing rate increase during sequences. However, these units did not effectively integrate whisker impulses, but instead combined weak impulse responses with a distinct, slow signal correlated to behavioral choice. A neural decoder could identify sequences from fast unit spike trains and behavioral choice from slow units. Thus, S1 encoded fast time scale whisker input without substantial temporal integration across whisker impulses.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
McGuire LM,Telian G,Laboy-Juárez KJ,Miyashita T,Lee DJ,Smith KA,Feldman DEdoi
10.1371/journal.pbio.1002549subject
Has Abstractpub_date
2016-08-30 00:00:00pages
e1002549issue
8eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-16-00249journal_volume
14pub_type
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