Abstract:
:Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Frank SA,Rosner MRdoi
10.1371/journal.pbio.1001296subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e1001296issue
4eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-11-04861journal_volume
10pub_type
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