One lipid, two synaptic plasticity pathways.

abstract：:How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance--the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively we...

journal_title：PLoS biology

authors： Råberg L

更新日期：2014-11-04 00:00:00

abstract：:Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells. Here, we show that Escherichia coli cell lineages exhibit comparable pa...

journal_title：PLoS biology

authors： Proenca AM,Rang CU,Qiu A,Shi C,Chao L

更新日期：2019-05-23 00:00:00

abstract：:Progress in science often begins with verbal hypotheses meant to explain why certain biological phenomena exist. An important purpose of mathematical models in evolutionary research, as in many other fields, is to act as “proof-of-concept” tests of the logic in verbal explanations, paralleling the way in which empiric...

journal_title：PLoS biology

authors： Servedio MR,Brandvain Y,Dhole S,Fitzpatrick CL,Goldberg EE,Stern CA,Van Cleve J,Yeh DJ

更新日期：2014-12-09 00:00:00

abstract：:Glial cells surround neuronal endings to create enclosed compartments required for neuronal function. This architecture is seen at excitatory synapses and at sensory neuron receptive endings. Despite the prevalence and importance of these compartments, how they form is not known. We used the main sensory organ of C. e...

journal_title：PLoS biology

authors： Oikonomou G,Perens EA,Lu Y,Watanabe S,Jorgensen EM,Shaham S

更新日期：2011-08-01 00:00:00

abstract：:Pollination is exclusively or mainly animal mediated for 70% to 90% of angiosperm species. Thus, pollinators provide an essential ecosystem service to humankind. However, the impact of human-induced biodiversity loss on the functioning of plant-pollinator interactions has not been tested experimentally. To understand ...

journal_title：PLoS biology

authors： Fontaine C,Dajoz I,Meriguet J,Loreau M

更新日期：2006-01-01 00:00:00

abstract：:Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with,...

journal_title：PLoS biology

authors： Prendergast L,van Vuuren C,Kaczmarczyk A,Doering V,Hellwig D,Quinn N,Hoischen C,Diekmann S,Sullivan KF

更新日期：2011-06-01 00:00:00

abstract：:The mechanism by which a complex auditory scene is parsed into coherent objects depends on poorly understood interactions between task-driven and stimulus-driven attentional processes. We illuminate these interactions in a simultaneous behavioral-neurophysiological study in which we manipulate participants' attention ...

journal_title：PLoS biology

authors： Elhilali M,Xiang J,Shamma SA,Simon JZ

更新日期：2009-06-01 00:00:00

abstract：:Pruning that selectively eliminates unnecessary axons/dendrites is crucial for sculpting the nervous system during development. During Drosophila metamorphosis, dendrite arborization neurons, ddaCs, selectively prune their larval dendrites in response to the steroid hormone ecdysone, whereas mushroom body γ neurons sp...

journal_title：PLoS biology

authors： Wong JJ,Li S,Lim EK,Wang Y,Wang C,Zhang H,Kirilly D,Wu C,Liou YC,Wang H,Yu F

更新日期：2013-09-01 00:00:00

abstract：:Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state. Yet, patterning processes during early development occur rapidly, and tissue patterning may...

journal_title：PLoS biology

authors： Bergmann S,Sandler O,Sberro H,Shnider S,Schejter E,Shilo BZ,Barkai N

更新日期：2007-02-01 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...

journal_title：PLoS biology

authors： Colón-Thillet R,Hsieh E,Graf L,McLaughlin RN Jr,Young JM,Kochs G,Emerman M,Malik HS

更新日期：2019-10-01 00:00:00

abstract：:Courtship is a widespread behavior in which one gender conveys to the other a series of cues about their species identity, gender, and suitability as mates. In many species, females decode these male displays and either accept or reject them. Despite the fact that courtship has been investigated for a long time, the g...

journal_title：PLoS biology

authors： Schinaman JM,Giesey RL,Mizutani CM,Lukacsovich T,Sousa-Neves R

更新日期：2014-10-07 00:00:00

abstract：:Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...

journal_title：PLoS biology

authors： Kompella P,Gracia B,LeBlanc L,Engelman S,Kulkarni C,Desai N,June V,March S,Pattengale S,Rodriguez-Rivera G,Ryu SW,Strohkendl I,Mandke P,Clark G

更新日期：2020-03-30 00:00:00

abstract：:PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...

journal_title：PLoS biology

authors： Fiorini N,Canese K,Starchenko G,Kireev E,Kim W,Miller V,Osipov M,Kholodov M,Ismagilov R,Mohan S,Ostell J,Lu Z

更新日期：2018-08-28 00:00:00

abstract：:Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a critical regulator o...

journal_title：PLoS biology

authors： Zhang X,Chen W,Gao Q,Yang J,Yan X,Zhao H,Su L,Yang M,Gao C,Yao Y,Inoki K,Li D,Shao R,Wang S,Sahoo N,Kudo F,Eguchi T,Ruan B,Xu H

更新日期：2019-05-21 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00

abstract：:Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located ...

journal_title：PLoS biology

authors： Stecker GC,Harrington IA,Middlebrooks JC

更新日期：2005-03-01 00:00:00

abstract：:Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...

journal_title：PLoS biology

authors： Fatsis-Kavalopoulos N,Roemhild R,Tang PC,Kreuger J,Andersson DI

更新日期：2020-09-17 00:00:00

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00

abstract：:Pollen tube (PT) reception in flowering plants describes the crosstalk between the male and female gametophytes upon PT arrival at the synergid cells of the ovule. It leads to PT growth arrest, rupture, and sperm cell release, and is thus essential to ensure double fertilization. Here, we describe TURAN (TUN) and EVAN...

journal_title：PLoS biology

authors： Lindner H,Kessler SA,Müller LM,Shimosato-Asano H,Boisson-Dernier A,Grossniklaus U

更新日期：2015-04-28 00:00:00

abstract：:Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...

journal_title：PLoS biology

authors： Varshney RK,Terauchi R,McCouch SR

更新日期：2014-06-10 00:00:00

abstract：:Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, which is loosely defined as a cohort of proteins that perform a dedicated...

journal_title：PLoS biology

authors： Batada NN,Reguly T,Breitkreutz A,Boucher L,Breitkreutz BJ,Hurst LD,Tyers M

更新日期：2006-10-01 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have designed synthetic "s...

journal_title：PLoS biology

authors： Francica JR,Laga R,Lynn GM,Mužíková G,Androvič L,Aussedat B,Walkowicz WE,Padhan K,Ramirez-Valdez RA,Parks R,Schmidt SD,Flynn BJ,Tsybovsky Y,Stewart-Jones GBE,Saunders KO,Baharom F,Petrovas C,Haynes BF,Seder RA

更新日期：2019-06-17 00:00:00

abstract：:Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....

journal_title：PLoS biology

authors： Qi YJ,Jiao YL,Chen P,Kong JY,Gu BL,Liu K,Feng DD,Zhu YF,Ruan HJ,Lan ZJ,Liu QW,Mi YJ,Guo XQ,Wang M,Liang GF,Lamont RJ,Wang H,Zhou FY,Feng XS,Gao SG

更新日期：2020-09-04 00:00:00

abstract：:Citizen science is mainstream: millions of people contribute data to a growing array of citizen science projects annually, forming massive datasets that will drive research for years to come. Many citizen science projects implement a "leaderboard" framework, ranking the contributions based on number of records or spec...

journal_title：PLoS biology

authors： Callaghan CT,Rowley JJL,Cornwell WK,Poore AGB,Major RE

更新日期：2019-06-27 00:00:00

abstract：:It has been reported that feeding mice resveratrol activates AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1α, increased mitochondrial biogenesis, and improved running endurance. This study was done to further evaluate the effects of resveratrol, SIRT1, and PGC-1α deacetylation on mi...

journal_title：PLoS biology

authors： Higashida K,Kim SH,Jung SR,Asaka M,Holloszy JO,Han DH

更新日期：2013-07-01 00:00:00

abstract：:Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding mo...

journal_title：PLoS biology

authors： Schoofs A,Hückesfeld S,Schlegel P,Miroschnikow A,Peters M,Zeymer M,Spieß R,Chiang AS,Pankratz MJ

更新日期：2014-06-24 00:00:00

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00