Improving big citizen science data: Moving beyond haphazard sampling.

abstract：:A large fraction of genome variation between individuals is comprised of submicroscopic copy number variation of genomic DNA segments. We assessed the relative contribution of structural changes and gene dosage alterations on phenotypic outcomes with mouse models of Smith-Magenis and Potocki-Lupski syndromes. We pheno...

journal_title：PLoS biology

authors： Ricard G,Molina J,Chrast J,Gu W,Gheldof N,Pradervand S,Schütz F,Young JI,Lupski JR,Reymond A,Walz K

更新日期：2010-11-23 00:00:00

abstract：:Recently, prominent theoretical linguists have argued for an explicit scenario for the evolution of the human language capacity on the basis of its computational properties. Concretely, the simplicity of a minimalist formulation of the operation Merge, which allows humans to recursively compute hierarchical relations ...

journal_title：PLoS biology

authors： Martins PT,Boeckx C

更新日期：2019-11-27 00:00:00

abstract：:Microbial endosymbiosis is widespread in animals, with major ecological and evolutionary implications. Successful symbiosis relies on efficient vertical transmission through host generations. However, when symbionts negatively affect host fitness, hosts are expected to evolve suppression of symbiont effects or transmi...

journal_title：PLoS biology

authors： Becking T,Chebbi MA,Giraud I,Moumen B,Laverré T,Caubet Y,Peccoud J,Gilbert C,Cordaux R

更新日期：2019-10-10 00:00:00

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...

journal_title：PLoS biology

authors： André V,Gau C,Scheideler A,Aguilar-Pimentel JA,Amarie OV,Becker L,Garrett L,Hans W,Hölter SM,Janik D,Moreth K,Neff F,Östereicher M,Racz I,Rathkolb B,Rozman J,Bekeredjian R,Graw J,Klingenspor M,Klopstock T,Ollert M

更新日期：2018-04-16 00:00:00

abstract：:Over the past decade, the high-dose refuge (HDR) strategy, aimed at delaying the evolution of pest resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops, became mandatory in the United States and is being discussed for Europe. However, precopulatory dispersal and the mating rate between residen...

journal_title：PLoS biology

authors： Dalecky A,Ponsard S,Bailey RI,Pélissier C,Bourguet D

更新日期：2006-06-01 00:00:00

abstract：:Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling ...

journal_title：PLoS biology

authors： Lau KS,Cortez-Retamozo V,Philips SR,Pittet MJ,Lauffenburger DA,Haigis KM

更新日期：2012-01-01 00:00:00

abstract：:In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...

journal_title：PLoS biology

authors： Palazzo AF,Springer M,Shibata Y,Lee CS,Dias AP,Rapoport TA

更新日期：2007-12-01 00:00:00

abstract：:The causes and mechanisms of evolutionary diversification are central issues in biology. Geographic isolation is the traditional explanation for diversification, but recent theoretical and empirical studies have shown that frequency-dependent selection can drive diversification without isolation and that adaptive dive...

journal_title：PLoS biology

authors： Herron MD,Doebeli M

更新日期：2013-01-01 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:From early dinosaurs with as many as nine wrist bones, modern birds evolved to develop only four ossifications. Their identity is uncertain, with different labels used in palaeontology and developmental biology. We examined embryos of several species and studied chicken embryos in detail through a new technique allowi...

journal_title：PLoS biology

authors： Botelho JF,Ossa-Fuentes L,Soto-Acuña S,Smith-Paredes D,Nuñez-León D,Salinas-Saavedra M,Ruiz-Flores M,Vargas AO

更新日期：2014-09-30 00:00:00

abstract：:The Global Health 2035 report notes that the "grand convergence"--closure of the infectious, maternal, and child mortality gap between rich and poor countries--is dependent on research and development (R&D) of new drugs, vaccines, diagnostics, and other health tools. However, this convergence (and the R&D underpinning...

journal_title：PLoS biology

authors： Moran M

更新日期：2016-03-02 00:00:00

abstract：:The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep dep...

journal_title：PLoS biology

authors： Porrino LJ,Daunais JB,Rogers GA,Hampson RE,Deadwyler SA

更新日期：2005-09-01 00:00:00

abstract：:The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcript...

journal_title：PLoS biology

authors： Meeske AJ,Rodrigues CD,Brady J,Lim HC,Bernhardt TG,Rudner DZ

更新日期：2016-01-06 00:00:00

abstract：:Misalignment of the daily sleep-wake and fasting-feeding cycles with the endogenous circadian timing system is an inevitable consequence of night shift work and is associated with adverse metabolic health effects. However, a detailed characterisation of the effects of night shifts on 24-h rhythms in the metabolome is ...

journal_title：PLoS biology

authors： Kervezee L,Cermakian N,Boivin DB

更新日期：2019-06-18 00:00:00

abstract：:Sixty-five years after Turing first revealed the potential of systems with local activation and long-range inhibition to generate pattern, we have only recently begun to identify the biological elements that operate at many scales to generate periodic patterns in nature. In this Primer, we first review the theoretical...

journal_title：PLoS biology

authors： Dalle Nogare D,Chitnis AB

更新日期：2017-12-20 00:00:00

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00

abstract：:Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have und...

journal_title：PLoS biology

authors： Rea SL,Ventura N,Johnson TE

更新日期：2007-10-02 00:00:00

abstract：:African swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat. ASFV DNA Polymerase X (AsfvPolX) is the most distinctive DNA polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologous proteins. AsfvPolX cataly...

journal_title：PLoS biology

authors： Chen Y,Zhang J,Liu H,Gao Y,Li X,Zheng L,Cui R,Yao Q,Rong L,Li J,Huang Z,Ma J,Gan J

更新日期：2017-02-28 00:00:00

abstract：:Pollination is exclusively or mainly animal mediated for 70% to 90% of angiosperm species. Thus, pollinators provide an essential ecosystem service to humankind. However, the impact of human-induced biodiversity loss on the functioning of plant-pollinator interactions has not been tested experimentally. To understand ...

journal_title：PLoS biology

authors： Fontaine C,Dajoz I,Meriguet J,Loreau M

更新日期：2006-01-01 00:00:00

abstract：:The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice ...

journal_title：PLoS biology

authors： Portera-Cailliau C,Weimer RM,De Paola V,Caroni P,Svoboda K

更新日期：2005-08-01 00:00:00

abstract：:The rapid destruction of the planet's biodiversity has prompted the nations of the world to set a target of achieving a significant reduction in the rate of loss of biodiversity by 2010. However, we do not yet have an adequate way of monitoring progress towards achieving this target. Here we present a method for produ...

journal_title：PLoS biology

authors： Butchart SH,Stattersfield AJ,Bennun LA,Shutes SM,Akçakaya HR,Baillie JE,Stuart SN,Hilton-Taylor C,Mace GM

更新日期：2004-12-01 00:00:00

abstract：:All organisms live in temporally fluctuating environments. Theory predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plasticity) underlies adaptation to environments that fluctuate in a predictably alternating fashion over maternal-offspri...

journal_title：PLoS biology

authors： Dey S,Proulx SR,Teotónio H

更新日期：2016-02-24 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a critical regulator o...

journal_title：PLoS biology

authors： Zhang X,Chen W,Gao Q,Yang J,Yan X,Zhao H,Su L,Yang M,Gao C,Yao Y,Inoki K,Li D,Shao R,Wang S,Sahoo N,Kudo F,Eguchi T,Ruan B,Xu H

更新日期：2019-05-21 00:00:00

abstract：:A vast and rich body of information has grown up as a result of the world's enthusiasm for 'omics technologies. Finding ways to describe and make available this information that maximise its usefulness has become a major effort across the 'omics world. At the heart of this effort is the Genomic Standards Consortium (G...

journal_title：PLoS biology

authors： Field D,Amaral-Zettler L,Cochrane G,Cole JR,Dawyndt P,Garrity GM,Gilbert J,Glöckner FO,Hirschman L,Karsch-Mizrachi I,Klenk HP,Knight R,Kottmann R,Kyrpides N,Meyer F,San Gil I,Sansone SA,Schriml LM,Sterk P,Tatusova T

更新日期：2011-06-01 00:00:00

abstract：:The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex pl...

journal_title：PLoS biology

authors： Moon BS,Yun HM,Chang WH,Steele BH,Cai M,Choi SH,Lu W

更新日期：2017-05-03 00:00:00

abstract：:The F-type ATP synthase complex is a rotary nano-motor driven by proton motive force to synthesize ATP. Its F(1) sector catalyzes ATP synthesis, whereas the F(o) sector conducts the protons and provides a stator for the rotary action of the complex. Components of both F(1) and F(o) sectors are highly conserved across ...

journal_title：PLoS biology

authors： Balabaskaran Nina P,Dudkina NV,Kane LA,van Eyk JE,Boekema EJ,Mather MW,Vaidya AB

更新日期：2010-07-13 00:00:00