Abstract:
:Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The female-specific neo-W chromosome of the African monarch (or queen) butterfly Danaus chrysippus presents an intriguing case study because it is restricted to a single 'contact zone' population, involves a putative colour patterning supergene, and co-occurs with infection by the male-killing endosymbiont Spiroplasma. We investigated the origin and evolution of this system using whole genome sequencing. We first identify the 'BC supergene', a broad region of suppressed recombination across nearly half a chromosome, which links two colour patterning loci. Association analysis suggests that the genes yellow and arrow in this region control the forewing colour pattern differences between D. chrysippus subspecies. We then show that the same chromosome has recently formed a neo-W that has spread through the contact zone within approximately 2,200 years. We also assembled the genome of the male-killing Spiroplasma, and find that it shows perfect genealogical congruence with the neo-W, suggesting that the neo-W has hitchhiked to high frequency as the male-killer has spread through the population. The complete absence of female crossing-over in the Lepidoptera causes whole-chromosome hitchhiking of a single neo-W haplotype, carrying a single allele of the BC supergene and dragging multiple non-synonymous mutations to high frequency. This has created a population of infected females that all carry the same recessive colour patterning allele, making the phenotypes of each successive generation highly dependent on uninfected male immigrants. Our findings show how hitchhiking can occur between the physically unlinked genomes of host and endosymbiont, with dramatic consequences.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Martin SH,Singh KS,Gordon IJ,Omufwoko KS,Collins S,Warren IA,Munby H,Brattström O,Traut W,Martins DJ,Smith DAS,Jiggins CD,Bass C,Ffrench-Constant RHdoi
10.1371/journal.pbio.3000610subject
Has Abstractpub_date
2020-02-27 00:00:00pages
e3000610issue
2eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-19-02265journal_volume
18pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000204
更新日期:2019-04-05 00:00:00
abstract::African swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat. ASFV DNA Polymerase X (AsfvPolX) is the most distinctive DNA polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologous proteins. AsfvPolX cataly...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002599
更新日期:2017-02-28 00:00:00
abstract::As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexpression in females ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001328
更新日期:2012-01-01 00:00:00
abstract::Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060305
更新日期:2008-12-09 00:00:00
abstract::Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001230
更新日期:2012-01-01 00:00:00
abstract::Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats. Here, we report that Drosophila larvae exhibit a novel appetitive feeding behavio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005570
更新日期:2018-08-07 00:00:00
abstract::Over the past decade, the high-dose refuge (HDR) strategy, aimed at delaying the evolution of pest resistance to Bacillus thuringiensis (Bt) toxins produced by transgenic crops, became mandatory in the United States and is being discussed for Europe. However, precopulatory dispersal and the mating rate between residen...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040181
更新日期:2006-06-01 00:00:00
abstract::Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated wit...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020296
更新日期:2004-09-01 00:00:00
abstract::Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005707
更新日期:2018-04-18 00:00:00
abstract::PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000122
更新日期:2019-01-18 00:00:00
abstract::FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important functions in devel...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001586
更新日期:2013-01-01 00:00:00
abstract::Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...
journal_title:PLoS biology
pub_type: 历史文章,杂志文章
doi:10.1371/journal.pbio.1001772
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2001951.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002603
更新日期:2017-05-01 00:00:00
abstract::The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000453
更新日期:2019-09-26 00:00:00
abstract::The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we have investigated wh...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001615
更新日期:2013-07-01 00:00:00
abstract::The evidence that diel patterns of physiology and behaviour in mammals are governed by circadian 'clocks' is based almost entirely on studies of nocturnal rodents. The emergent circadian paradigm, however, neglects the roles of energy metabolism and alimentary function (feeding and digestion) as determinants of activi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000360
更新日期:2019-07-15 00:00:00
abstract::Rapid colour change is a remarkable natural phenomenon that has evolved in several vertebrate and invertebrate lineages. The two principal explanations for the evolution of this adaptive strategy are (1) natural selection for crypsis (camouflage) against a range of different backgrounds and (2) selection for conspicuo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060025
更新日期:2008-01-01 00:00:00
abstract::The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060256
更新日期:2008-10-28 00:00:00
abstract::Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002253
更新日期:2015-09-22 00:00:00
abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002711
更新日期:2017-06-26 00:00:00
abstract::The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001013
更新日期:2011-02-08 00:00:00
abstract::Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approxi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002165
更新日期:2015-06-09 00:00:00
abstract::The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo sup...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000382
更新日期:2019-07-19 00:00:00
abstract::Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, with especially little known about how tolerance is manifested in natu...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001901
更新日期:2014-07-08 00:00:00
abstract::Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS1...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000313
更新日期:2019-06-11 00:00:00
abstract::Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000086
更新日期:2009-04-07 00:00:00
abstract::Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties, but the mechanisms regulating synapse-specific Ca2+ homeostasis in...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002516
更新日期:2016-07-18 00:00:00
abstract::Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001808
更新日期:2014-03-11 00:00:00
abstract::Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we ident...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002409
更新日期:2016-03-24 00:00:00
abstract::Several studies have demonstrated that poor early nutrition, followed by growth compensation, can have negative consequences later in life. However, it remains unclear whether this is attributable to the nutritional deficit itself or a cost of compensatory growth. This distinction is important to our understanding bot...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040251
更新日期:2006-07-01 00:00:00