Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.


:[This corrects the article DOI: 10.1371/journal.pbio.2001951.].


PLoS Biol


PLoS biology


Di Biase S,Shim HS,Kim KH,Vinciguerra M,Rappa F,Wei M,Brandhorst S,Cappello F,Mirzaei H,Lee C,Longo VD




Has Abstract


2017-05-01 00:00:00














  • Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns.

    abstract::The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Kelsch W,Mosley CP,Lin CW,Lois C

    更新日期:2007-11-01 00:00:00

  • Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum.

    abstract::Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demo...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Theisen U,Hennig C,Ring T,Schnabel R,Köster RW

    更新日期:2018-01-04 00:00:00

  • Ethoscopes: An open platform for high-throughput ethomics.

    abstract::Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Geissmann Q,Garcia Rodriguez L,Beckwith EJ,French AS,Jamasb AR,Gilestro GF

    更新日期:2017-10-19 00:00:00

  • Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor.

    abstract::Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

    更新日期:2021-01-04 00:00:00

  • Protein flexibility facilitates quaternary structure assembly and evolution.

    abstract::The intrinsic flexibility of proteins allows them to undergo large conformational fluctuations in solution or upon interaction with other molecules. Proteins also commonly assemble into complexes with diverse quaternary structure arrangements. Here we investigate how the flexibility of individual protein chains influe...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Marsh JA,Teichmann SA

    更新日期:2014-05-27 00:00:00

  • The Grand Convergence: Closing the Divide between Public Health Funding and Global Health Needs.

    abstract::The Global Health 2035 report notes that the "grand convergence"--closure of the infectious, maternal, and child mortality gap between rich and poor countries--is dependent on research and development (R&D) of new drugs, vaccines, diagnostics, and other health tools. However, this convergence (and the R&D underpinning...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Moran M

    更新日期:2016-03-02 00:00:00

  • Inferring the dynamics of diversification: a coalescent approach.

    abstract::Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Morlon H,Potts MD,Plotkin JB

    更新日期:2010-09-28 00:00:00

  • Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group.

    abstract::Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Crawley D,Zhang L,Jones EJH,Ahmad J,Oakley B,San José Cáceres A,Charman T,Buitelaar JK,Murphy DGM,Chatham C,den Ouden H,Loth E,EU-AIMS LEAP group.

    更新日期:2020-10-27 00:00:00

  • Imre Festetics and the Sheep Breeders' Society of Moravia: Mendel's Forgotten "Research Network".

    abstract::Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...

    journal_title:PLoS biology

    pub_type: 历史文章,杂志文章


    authors: Poczai P,Bell N,Hyvönen J

    更新日期:2014-01-01 00:00:00

  • Building a local community of practice in scientific programming for life scientists.

    abstract::In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Stevens SLR,Kuzak M,Martinez C,Moser A,Bleeker P,Galland M

    更新日期:2018-11-28 00:00:00

  • Improving big citizen science data: Moving beyond haphazard sampling.

    abstract::Citizen science is mainstream: millions of people contribute data to a growing array of citizen science projects annually, forming massive datasets that will drive research for years to come. Many citizen science projects implement a "leaderboard" framework, ranking the contributions based on number of records or spec...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Callaghan CT,Rowley JJL,Cornwell WK,Poore AGB,Major RE

    更新日期:2019-06-27 00:00:00

  • Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process.

    abstract::In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analyzing primary chicke...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Richard A,Boullu L,Herbach U,Bonnafoux A,Morin V,Vallin E,Guillemin A,Papili Gao N,Gunawan R,Cosette J,Arnaud O,Kupiec JJ,Espinasse T,Gonin-Giraud S,Gandrillon O

    更新日期:2016-12-27 00:00:00

  • Analysis of LhcSR3, a protein essential for feedback de-excitation in the green alga Chlamydomonas reinhardtii.

    abstract::In photosynthetic organisms, feedback dissipation of excess absorbed light energy balances harvesting of light with metabolic energy consumption. This mechanism prevents photodamage caused by reactive oxygen species produced by the reaction of chlorophyll (Chl) triplet states with O₂. Plants have been found to perform...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Bonente G,Ballottari M,Truong TB,Morosinotto T,Ahn TK,Fleming GR,Niyogi KK,Bassi R

    更新日期:2011-01-18 00:00:00

  • EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers.

    abstract::Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Pan M,Schinke H,Luxenburger E,Kranz G,Shakhtour J,Libl D,Huang Y,Gaber A,Pavšič M,Lenarčič B,Kitz J,Jakob M,Schwenk-Zieger S,Canis M,Hess J,Unger K,Baumeister P,Gires O

    更新日期:2018-09-27 00:00:00

  • Correction: Publication reform to safeguard wildlife from researcher harm.

    abstract::[This corrects the article DOI: 10.1371/journal.pbio.3000193.]. ...

    journal_title:PLoS biology

    pub_type: 杂志文章,已发布勘误


    authors: Field KA,Paquet PC,Artelle K,Proulx G,Brook RK,Darimont CT

    更新日期:2020-05-18 00:00:00

  • Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.

    abstract::The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

    更新日期:2013-01-01 00:00:00

  • Structural studies of the giant mimivirus.

    abstract::Mimivirus is the largest known virus whose genome and physical size are comparable to some small bacteria, blurring the boundary between a virus and a cell. Structural studies of Mimivirus have been difficult because of its size and long surface fibers. Here we report the use of enzymatic digestions to remove the surf...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Xiao C,Kuznetsov YG,Sun S,Hafenstein SL,Kostyuchenko VA,Chipman PR,Suzan-Monti M,Raoult D,McPherson A,Rossmann MG

    更新日期:2009-04-28 00:00:00

  • Why is congenital Zika syndrome asymmetrically distributed among human populations?

    abstract::Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...

    journal_title:PLoS biology

    pub_type: 杂志文章,评审


    authors: Barbeito-Andrés J,Schuler-Faccini L,Garcez PP

    更新日期:2018-08-24 00:00:00

  • Correction: Tracking Resilience to Infections by Mapping Disease Space.

    abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002436.]. ...

    journal_title:PLoS biology

    pub_type: 已发布勘误


    authors: PLOS Biology Staff.

    更新日期:2016-06-08 00:00:00

  • GAD2 on chromosome 10p12 is a candidate gene for human obesity.

    abstract::The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

    更新日期:2003-12-01 00:00:00

  • BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites.

    abstract::Chromatin insulators/boundary elements share the ability to insulate a transgene from its chromosomal context by blocking promiscuous enhancer-promoter interactions and heterochromatin spreading. Several insulating factors target different DNA consensus sequences, defining distinct subfamilies of insulators. Whether e...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Emberly E,Blattes R,Schuettengruber B,Hennion M,Jiang N,Hart CM,Käs E,Cuvier O

    更新日期:2008-12-23 00:00:00

  • Multiple locus linkage analysis of genomewide expression in yeast.

    abstract::With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena. The genetics of transcriptional regulation and protein abundance are likely to be complex, meaning that genetic variation at multiple loci will infl...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Storey JD,Akey JM,Kruglyak L

    更新日期:2005-08-01 00:00:00

  • Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle.

    abstract::CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated from injured Pax7( ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Seale P,Ishibashi J,Scimè A,Rudnicki MA

    更新日期:2004-05-01 00:00:00

  • Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors.

    abstract::Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide (HX). This paradigm is at the basis of the vast majority of expe...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Hudry B,Remacle S,Delfini MC,Rezsohazy R,Graba Y,Merabet S

    更新日期:2012-01-01 00:00:00

  • Revisiting the basic reproductive number for malaria and its implications for malaria control.

    abstract::The prospects for the success of malaria control depend, in part, on the basic reproductive number for malaria, R0. Here, we estimate R0 in a novel way for 121 African populations, and thereby increase the number of R0 estimates for malaria by an order of magnitude. The estimates range from around one to more than 3,0...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Smith DL,McKenzie FE,Snow RW,Hay SI

    更新日期:2007-03-01 00:00:00

  • Parallel evolutionary dynamics of adaptive diversification in Escherichia coli.

    abstract::The causes and mechanisms of evolutionary diversification are central issues in biology. Geographic isolation is the traditional explanation for diversification, but recent theoretical and empirical studies have shown that frequency-dependent selection can drive diversification without isolation and that adaptive dive...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Herron MD,Doebeli M

    更新日期:2013-01-01 00:00:00

  • A Speculative History of DNA: What If Oswald Avery Had Died in 1934?

    abstract::This speculative Essay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided evidence that genes are made of DNA. Four imaginary alternate routes to the genetic function of DNA are outlined, each of which highlights different aspects of the actual process of discovery. ...

    journal_title:PLoS biology

    pub_type: 传,历史文章,杂志文章


    authors: Cobb M

    更新日期:2016-12-22 00:00:00

  • Flight speeds among bird species: allometric and phylogenetic effects.

    abstract::Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Alerstam T,Rosén M,Bäckman J,Ericson PG,Hellgren O

    更新日期:2007-08-01 00:00:00

  • Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.

    abstract::Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the l...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

    更新日期:2020-11-13 00:00:00

  • Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.

    abstract::The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Hoang HD,Miller MA

    更新日期:2017-06-29 00:00:00