Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.


:The fate of neural progenitor cells (NPCs) during corticogenesis is determined by a complex interplay of genetic or epigenetic components, but the underlying mechanism is incompletely understood. Here, we demonstrate that Suppressor of Mek null (Smek) interact with methyl-CpG-binding domain 3 (Mbd3) and the complex plays a critical role in self-renewal and neuronal differentiation of NPCs. We found that Smek promotes Mbd3 polyubiquitylation and degradation, blocking recruitment of the repressive Mbd3/nucleosome remodeling and deacetylase (NuRD) complex at the neurogenesis-associated gene loci, and, as a consequence, increasing acetyl histone H3 activity and cortical neurogenesis. Furthermore, overexpression of Mbd3 significantly blocked neuronal differentiation of NPCs, and Mbd3 depletion rescued neurogenesis defects seen in Smek1/2 knockout mice. These results reveal a novel molecular mechanism underlying Smek/Mbd3/NuRD axis-mediated control of NPCs' self-renewal and neuronal differentiation during mammalian corticogenesis.


PLoS Biol


PLoS biology


Moon BS,Yun HM,Chang WH,Steele BH,Cai M,Choi SH,Lu W




Has Abstract


2017-05-03 00:00:00














  • Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.

    abstract::Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Meharena HS,Fan X,Ahuja LG,Keshwani MM,McClendon CL,Chen AM,Adams JA,Taylor SS

    更新日期:2016-11-30 00:00:00

  • Parallel evolutionary dynamics of adaptive diversification in Escherichia coli.

    abstract::The causes and mechanisms of evolutionary diversification are central issues in biology. Geographic isolation is the traditional explanation for diversification, but recent theoretical and empirical studies have shown that frequency-dependent selection can drive diversification without isolation and that adaptive dive...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Herron MD,Doebeli M

    更新日期:2013-01-01 00:00:00

  • Lineage-specific gene duplication and loss in human and great ape evolution.

    abstract::Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Fortna A,Kim Y,MacLaren E,Marshall K,Hahn G,Meltesen L,Brenton M,Hink R,Burgers S,Hernandez-Boussard T,Karimpour-Fard A,Glueck D,McGavran L,Berry R,Pollack J,Sikela JM

    更新日期:2004-07-01 00:00:00

  • Dopamine modulates subcortical responses to surprising sounds.

    abstract::Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Valdés-Baizabal C,Carbajal GV,Pérez-González D,Malmierca MS

    更新日期:2020-06-19 00:00:00

  • The Grand Convergence: Closing the Divide between Public Health Funding and Global Health Needs.

    abstract::The Global Health 2035 report notes that the "grand convergence"--closure of the infectious, maternal, and child mortality gap between rich and poor countries--is dependent on research and development (R&D) of new drugs, vaccines, diagnostics, and other health tools. However, this convergence (and the R&D underpinning...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Moran M

    更新日期:2016-03-02 00:00:00

  • Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition.

    abstract::Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Calleja V,Laguerre M,Parker PJ,Larijani B

    更新日期:2009-01-20 00:00:00

  • Motivational salience signal in the basal forebrain is coupled with faster and more precise decision speed.

    abstract::The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Avila I,Lin SC

    更新日期:2014-03-18 00:00:00

  • Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.

    abstract::Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Andressoo JO,Jans J,de Wit J,Coin F,Hoogstraten D,van de Ven M,Toussaint W,Huijmans J,Thio HB,van Leeuwen WJ,de Boer J,Egly JM,Hoeijmakers JH,van der Horst GT,Mitchell JR

    更新日期:2006-10-01 00:00:00

  • ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.

    abstract::Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost in cells using the alternative lengthening of telomeres (ALT) pathway, but it is not known how ATRX loss leads to ALT. We report that ATRX deletion from mouse c...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Lovejoy CA,Takai K,Huh MS,Picketts DJ,de Lange T

    更新日期:2020-01-02 00:00:00

  • The cell cycle-regulated genes of Schizosaccharomyces pombe.

    abstract::Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

    更新日期:2005-07-01 00:00:00

  • Precise positioning of myosin VI on endocytic vesicles in vivo.

    abstract::Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

    更新日期:2007-08-01 00:00:00

  • The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development.

    abstract::Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Hipfner DR,Cohen SM

    更新日期:2003-11-01 00:00:00

  • Structure-guided recombination creates an artificial family of cytochromes P450.

    abstract::Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising 3,000 P450 heme proteins that correctly fold and incorporate a heme cofactor by recombi...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Otey CR,Landwehr M,Endelman JB,Hiraga K,Bloom JD,Arnold FH

    更新日期:2006-05-01 00:00:00

  • Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation.

    abstract::It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffec...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Yao CH,Liu GY,Wang R,Moon SH,Gross RW,Patti GJ

    更新日期:2018-03-29 00:00:00

  • Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia.

    abstract::Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

    更新日期:2020-12-07 00:00:00

  • GAD2 on chromosome 10p12 is a candidate gene for human obesity.

    abstract::The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

    更新日期:2003-12-01 00:00:00

  • Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.

    abstract::Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal proportions with other tissues. In vertebrates, local catch-up growth h...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Roselló-Díez A,Madisen L,Bastide S,Zeng H,Joyner AL

    更新日期:2018-06-26 00:00:00

  • Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.

    abstract::The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Hoang HD,Miller MA

    更新日期:2017-06-29 00:00:00

  • Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation.

    abstract::Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide lab...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Arnoldini M,Vizcarra IA,Peña-Miller R,Stocker N,Diard M,Vogel V,Beardmore RE,Hardt WD,Ackermann M

    更新日期:2014-08-19 00:00:00

  • Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum.

    abstract::Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Zhang X,Alexander N,Leonardi I,Mason C,Kirkman LA,Deitsch KW

    更新日期:2019-05-13 00:00:00

  • How to live with the enemy: understanding tolerance to parasites.

    abstract::How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance--the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively we...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Råberg L

    更新日期:2014-11-04 00:00:00

  • Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.

    abstract::Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Wang S,Jiang B,Zhang T,Liu L,Wang Y,Wang Y,Chen X,Lin H,Zhou L,Xia Y,Chen L,Yang C,Xiong Y,Ye D,Guan KL

    更新日期:2015-09-10 00:00:00

  • Porphyromonas gingivalis promotes progression of esophageal squamous cell cancer via TGFβ-dependent Smad/YAP/TAZ signaling.

    abstract::Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Qi YJ,Jiao YL,Chen P,Kong JY,Gu BL,Liu K,Feng DD,Zhu YF,Ruan HJ,Lan ZJ,Liu QW,Mi YJ,Guo XQ,Wang M,Liang GF,Lamont RJ,Wang H,Zhou FY,Feng XS,Gao SG

    更新日期:2020-09-04 00:00:00

  • Correction: JMJD5 links CRY1 function and proteasomal degradation.

    abstract::[This corrects the article DOI: 10.1371/journal.pbio.2006145.]. ...

    journal_title:PLoS biology

    pub_type: 已发布勘误


    authors: Saran AR,Kalinowska D,Oh S,Janknecht R,DiTacchio L

    更新日期:2019-08-21 00:00:00

  • The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.

    abstract::Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Tonkin-Hill GQ,Trianty L,Noviyanti R,Nguyen HHT,Sebayang BF,Lampah DA,Marfurt J,Cobbold SA,Rambhatla JS,McConville MJ,Rogerson SJ,Brown GV,Day KP,Price RN,Anstey NM,Papenfuss AT,Duffy MF

    更新日期:2018-03-12 00:00:00

  • Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment.

    abstract::Independently evolving populations may adapt to similar selection pressures via different genetic changes. The interactions between such changes, such as in a hybrid individual, can inform us about what course adaptation may follow and allow us to determine whether gene flow would be facilitated or hampered following ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ono J,Gerstein AC,Otto SP

    更新日期:2017-01-23 00:00:00

  • Correction: Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines.

    abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002454.]. ...

    journal_title:PLoS biology

    pub_type: 杂志文章,已发布勘误


    authors: Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

    更新日期:2018-03-14 00:00:00

  • A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage.

    abstract::In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the los...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Newell PD,Boyd CD,Sondermann H,O'Toole GA

    更新日期:2011-02-01 00:00:00

  • Low Genetic Quality Alters Key Dimensions of the Mutational Spectrum.

    abstract::Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Sharp NP,Agrawal AF

    更新日期:2016-03-25 00:00:00

  • Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.

    abstract::FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important functions in devel...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Sancho R,Blake SM,Tendeng C,Clurman BE,Lewis J,Behrens A

    更新日期:2013-01-01 00:00:00