Abstract:
:Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However, as we learn more about this evolutionarily ancient process, we are discovering that autophagy's effects may work for both the good and the bad of an organism. Here, I discuss some of these context-dependent findings and how, as we make sense of them, we can try to apply our knowledge for practical purposes.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Thorburn Adoi
10.1371/journal.pbio.1001967subject
Has Abstractpub_date
2014-10-14 00:00:00pages
e1001967issue
10eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-14-02582journal_volume
12pub_type
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