Abstract:
:Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demonstrate that intracellular calcium transients occur in cerebellar neurons of zebrafish embryos during migration. We show that depolarization increases and hyperpolarization reduces the speed of tegmental hindbrain neurons using optogenetic tools and advanced track analysis optimized for in vivo migration. Finally, we introduce a compound screening assay to identify acetylcholine (ACh), glutamate, and glycine as regulators of migration, which act regionally along the neurons' route. We summarize our findings in a model describing how different neurotransmitters spatially interact to control neuronal migration. The high evolutionary conservation of the cerebellum and hindbrain makes it likely that polarization state-driven motility constitutes an important principle in building a functional brain.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Theisen U,Hennig C,Ring T,Schnabel R,Köster RWdoi
10.1371/journal.pbio.2002226subject
Has Abstractpub_date
2018-01-04 00:00:00pages
e2002226issue
1eissn
1544-9173issn
1545-7885pii
pbio.2002226journal_volume
16pub_type
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