Networking in the Plant Microbiome.

abstract：:The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a uniqu...

journal_title：PLoS biology

authors： Strech D,Weissgerber T,Dirnagl U,QUEST Group.

更新日期：2020-02-11 00:00:00

abstract：:Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains unclear how these FRC-derived mediators dampen T-cell responses and wheth...

journal_title：PLoS biology

authors： Schaeuble K,Cannelle H,Favre S,Huang HY,Oberle SG,Speiser DE,Zehn D,Luther SA

更新日期：2019-07-15 00:00:00

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00

abstract：:Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in local zinc concentration. To understand how microorganisms coordinate a dynamic response to changes in zinc availability at the molecular level, we evaluated the...

journal_title：PLoS biology

authors： Gilston BA,Wang S,Marcus MD,Canalizo-Hernández MA,Swindell EP,Xue Y,Mondragón A,O'Halloran TV

更新日期：2014-11-04 00:00:00

abstract：:Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic...

journal_title：PLoS biology

authors： Halley-Stott RP,Jullien J,Pasque V,Gurdon J

更新日期：2014-07-29 00:00:00

abstract：:The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

journal_title：PLoS biology

authors： Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

更新日期：2013-01-01 00:00:00

abstract：:The mechanism by which a complex auditory scene is parsed into coherent objects depends on poorly understood interactions between task-driven and stimulus-driven attentional processes. We illuminate these interactions in a simultaneous behavioral-neurophysiological study in which we manipulate participants' attention ...

journal_title：PLoS biology

authors： Elhilali M,Xiang J,Shamma SA,Simon JZ

更新日期：2009-06-01 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...

journal_title：PLoS biology

authors： Oliva A,Rosebrock A,Ferrezuelo F,Pyne S,Chen H,Skiena S,Futcher B,Leatherwood J

更新日期：2005-07-01 00:00:00

abstract：:The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of the misfolded chan...

journal_title：PLoS biology

authors： Veit G,Oliver K,Apaja PM,Perdomo D,Bidaud-Meynard A,Lin ST,Guo J,Icyuz M,Sorscher EJ,Hartman JL IV,Lukacs GL

更新日期：2016-05-11 00:00:00

abstract：:Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...

journal_title：PLoS biology

authors： Hoehl S,Markova G

更新日期：2018-12-13 00:00:00

abstract：:Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PABPC1 is a crucial de...

journal_title：PLoS biology

authors： Eberle AB,Stalder L,Mathys H,Orozco RZ,Mühlemann O

更新日期：2008-04-29 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the...

journal_title：PLoS biology

authors： Landgraf C,Panni S,Montecchi-Palazzi L,Castagnoli L,Schneider-Mergener J,Volkmer-Engert R,Cesareni G

更新日期：2004-01-01 00:00:00

abstract：:Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal...

journal_title：PLoS biology

authors： Giacobini P,Parkash J,Campagne C,Messina A,Casoni F,Vanacker C,Langlet F,Hobo B,Cagnoni G,Gallet S,Hanchate NK,Mazur D,Taniguchi M,Mazzone M,Verhaagen J,Ciofi P,Bouret SG,Tamagnone L,Prevot V

更新日期：2014-03-11 00:00:00

abstract：:Gene expression in eukaryotes is controlled by DNA sequences at promoter and enhancer regions, whose accessibility for binding by regulatory proteins dictates their specific patterns of activity. Here, we identify the protein Zbtb7a as a factor required for inducible changes in accessibility driven by transcription fa...

journal_title：PLoS biology

authors： Ramos Pittol JM,Oruba A,Mittler G,Saccani S,van Essen D

更新日期：2018-05-29 00:00:00

abstract：:A large repertoire of natural object manipulation tasks require precisely coupled symmetrical opposing forces by both hands on a single object. We asked how the lateralized brain handles this basic problem of spatial and temporal coordination. We show that the brain consistently appoints one of the hands as prime acto...

journal_title：PLoS biology

authors： Johansson RS,Theorin A,Westling G,Andersson M,Ohki Y,Nyberg L

更新日期：2006-06-01 00:00:00

abstract：:The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to adiponectin recepto...

journal_title：PLoS biology

authors： Nader N,Dib M,Hodeify R,Courjaret R,Elmi A,Hammad AS,Dey R,Huang XY,Machaca K

更新日期：2020-11-02 00:00:00

abstract：:The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regions of the longest ...

journal_title：PLoS biology

authors： Sherwood NT,Sun Q,Xue M,Zhang B,Zinn K

更新日期：2004-12-01 00:00:00

abstract：:The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. He...

journal_title：PLoS biology

authors： Avila I,Lin SC

更新日期：2014-03-18 00:00:00

abstract：:Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...

journal_title：PLoS biology

authors： Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner R

更新日期：2013-12-01 00:00:00

abstract：:From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcript heterogeneity in single Saccharomyces cerevisiae cells treated with...

journal_title：PLoS biology

authors： Gasch AP,Yu FB,Hose J,Escalante LE,Place M,Bacher R,Kanbar J,Ciobanu D,Sandor L,Grigoriev IV,Kendziorski C,Quake SR,McClean MN

更新日期：2017-12-14 00:00:00

abstract：:Rodent whisker input consists of dense microvibration sequences that are often temporally integrated for perceptual discrimination. Whether primary somatosensory cortex (S1) participates in temporal integration is unknown. We trained rats to discriminate whisker impulse sequences that varied in single-impulse kinemati...

journal_title：PLoS biology

authors： McGuire LM,Telian G,Laboy-Juárez KJ,Miyashita T,Lee DJ,Smith KA,Feldman DE

更新日期：2016-08-30 00:00:00

abstract：:Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function. In bacteria, stochastic g...

journal_title：PLoS biology

authors： Levy SF,Ziv N,Siegal ML

更新日期：2012-01-01 00:00:00

abstract：:Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...

journal_title：PLoS biology

authors： Knapp BD,Zhu L,Huang KC

更新日期：2020-11-06 00:00:00

abstract：:Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal proportions with other tissues. In vertebrates, local catch-up growth h...

journal_title：PLoS biology

authors： Roselló-Díez A,Madisen L,Bastide S,Zeng H,Joyner AL

更新日期：2018-06-26 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:How should funding agencies enable researchers to explore high-risk but potentially high-reward science? One model that appears to work is the NSF-funded synthesis center, an incubator for community-led, innovative science. ...

journal_title：PLoS biology

authors： Rodrigo A,Alberts S,Cranston K,Kingsolver J,Lapp H,McClain C,Smith R,Vision T,Weintraub J,Wiegmann B

更新日期：2013-01-01 00:00:00

abstract：:Every year, ovarian cancer kills approximately 14,000 women in the United States and more than 140,000 women worldwide. Most of these deaths are caused by tumors of the serous histological type, which is rarely diagnosed before it has disseminated. By deep paired-end sequencing of mRNA from serous ovarian cancers, fol...

journal_title：PLoS biology

authors： Salzman J,Marinelli RJ,Wang PL,Green AE,Nielsen JS,Nelson BH,Drescher CW,Brown PO

更新日期：2011-09-01 00:00:00