Perception of odors linked to precise timing in the olfactory system.

Abstract:

:While the timing of neuronal activity in the olfactory bulb (OB) relative to sniffing has been the object of many studies, the behavioral relevance of timing information generated by patterned activation within the bulbar response has not been explored. Here we show, using sniff-triggered, dynamic, 2-D, optogenetic stimulation of mitral/tufted cells, that virtual odors that differ by as little as 13 ms are distinguishable by mice. Further, mice are capable of discriminating a virtual odor movie based on an optically imaged OB odor response versus the same virtual odor devoid of temporal dynamics-independently of the sniff-phase. Together with studies showing the behavioral relevance of graded glomerular responses and the response timing relative to odor sampling, these results imply that the mammalian olfactory system is capable of very high transient information transmission rates.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Rebello MR,McTavish TS,Willhite DC,Short SM,Shepherd GM,Verhagen JV

doi

10.1371/journal.pbio.1002021

subject

Has Abstract

pub_date

2014-12-16 00:00:00

pages

e1002021

issue

12

eissn

1544-9173

issn

1545-7885

pii

PBIOLOGY-D-14-01927

journal_volume

12

pub_type

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