Abstract:
:While the timing of neuronal activity in the olfactory bulb (OB) relative to sniffing has been the object of many studies, the behavioral relevance of timing information generated by patterned activation within the bulbar response has not been explored. Here we show, using sniff-triggered, dynamic, 2-D, optogenetic stimulation of mitral/tufted cells, that virtual odors that differ by as little as 13 ms are distinguishable by mice. Further, mice are capable of discriminating a virtual odor movie based on an optically imaged OB odor response versus the same virtual odor devoid of temporal dynamics-independently of the sniff-phase. Together with studies showing the behavioral relevance of graded glomerular responses and the response timing relative to odor sampling, these results imply that the mammalian olfactory system is capable of very high transient information transmission rates.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Rebello MR,McTavish TS,Willhite DC,Short SM,Shepherd GM,Verhagen JVdoi
10.1371/journal.pbio.1002021subject
Has Abstractpub_date
2014-12-16 00:00:00pages
e1002021issue
12eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-14-01927journal_volume
12pub_type
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