Birds, blooms, and evolving diversity.


:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits.


PLoS Biol


PLoS biology


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2018-10-04 00:00:00














  • VirE2: a unique ssDNA-compacting molecular machine.

    abstract::The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis. Whereas bacterial conjugation spreads antibiotic resistance, Agrobacterium facilitates efficient interkingdom transfer of ssDNA from...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Grange W,Duckely M,Husale S,Jacob S,Engel A,Hegner M

    更新日期:2008-02-01 00:00:00

  • Organized unidirectional waves of ATP hydrolysis within a RecA filament.

    abstract::The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP hydrolysis. When filaments form on duplex DNA, RecA protein exhibits a fu...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Cox JM,Tsodikov OV,Cox MM

    更新日期:2005-02-01 00:00:00

  • Feeling fooled: Texture contaminates the neural code for tactile speed.

    abstract::Motion is an essential component of everyday tactile experience: most manual interactions involve relative movement between the skin and objects. Much of the research on the neural basis of tactile motion perception has focused on how direction is encoded, but less is known about how speed is. Perceived speed has been...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Delhaye BP,O'Donnell MK,Lieber JD,McLellan KR,Bensmaia SJ

    更新日期:2019-08-27 00:00:00

  • Identification of FAM173B as a protein methyltransferase promoting chronic pain.

    abstract::Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Willemen HLDM,Kavelaars A,Prado J,Maas M,Versteeg S,Nellissen LJJ,Tromp J,Gonzalez Cano R,Zhou W,Jakobsson ME,Małecki J,Posthuma G,Habib AM,Heijnen CJ,Falnes PØ,Eijkelkamp N

    更新日期:2018-02-14 00:00:00

  • Feminizer and doublesex knock-outs cause honey bees to switch sexes.

    abstract::Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of eff...

    journal_title:PLoS biology

    pub_type: 评论,杂志文章


    authors: McAfee A,Pettis JS,Tarpy DR,Foster LJ

    更新日期:2019-05-06 00:00:00

  • Ligands for pheromone-sensing neurons are not conformationally activated odorant binding proteins.

    abstract::Pheromones form an essential chemical language of intraspecific communication in many animals. How olfactory systems recognize pheromonal signals with both sensitivity and specificity is not well understood. An important in vivo paradigm for this process is the detection mechanism of the sex pheromone (Z)-11-octadecen...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Gomez-Diaz C,Reina JH,Cambillau C,Benton R

    更新日期:2013-01-01 00:00:00

  • Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

    abstract::Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to iden...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Riethmueller S,Somasundaram P,Ehlers JC,Hung CW,Flynn CM,Lokau J,Agthe M,Düsterhöft S,Zhu Y,Grötzinger J,Lorenzen I,Koudelka T,Yamamoto K,Pickhinke U,Wichert R,Becker-Pauly C,Rädisch M,Albrecht A,Hessefort M,Stahnke

    更新日期:2017-01-06 00:00:00

  • Inferring the dynamics of diversification: a coalescent approach.

    abstract::Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches. Under this hypothesis, speciation rates decay over time and biodiversity eventually saturates, with ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Morlon H,Potts MD,Plotkin JB

    更新日期:2010-09-28 00:00:00

  • The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation.

    abstract::DEAD-box proteins are ubiquitous regulators of RNA biology. While commonly dubbed "helicases," their activities also include duplex annealing, adenosine triphosphate (ATP)-dependent RNA binding, and RNA-protein complex remodeling. Rok1, an essential DEAD-box protein, and its cofactor Rrp5 are required for ribosome ass...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Khoshnevis S,Askenasy I,Johnson MC,Dattolo MD,Young-Erdos CL,Stroupe ME,Karbstein K

    更新日期:2016-06-09 00:00:00

  • Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath).

    abstract::Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

    更新日期:2004-10-01 00:00:00

  • An Estimate of the Total DNA in the Biosphere.

    abstract::Modern whole-organism genome analysis, in combination with biomass estimates, allows us to estimate a lower bound on the total information content in the biosphere: 5.3 × 1031 (±3.6 × 1031) megabases (Mb) of DNA. Given conservative estimates regarding DNA transcription rates, this information content suggests biospher...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Landenmark HK,Forgan DH,Cockell CS

    更新日期:2015-06-11 00:00:00

  • Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants.

    abstract::Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Chao DY,Chen Y,Chen J,Shi S,Chen Z,Wang C,Danku JM,Zhao FJ,Salt DE

    更新日期:2014-12-02 00:00:00

  • Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models.

    abstract::A large fraction of genome variation between individuals is comprised of submicroscopic copy number variation of genomic DNA segments. We assessed the relative contribution of structural changes and gene dosage alterations on phenotypic outcomes with mouse models of Smith-Magenis and Potocki-Lupski syndromes. We pheno...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ricard G,Molina J,Chrast J,Gu W,Gheldof N,Pradervand S,Schütz F,Young JI,Lupski JR,Reymond A,Walz K

    更新日期:2010-11-23 00:00:00

  • Mitosis gives a brief window of opportunity for a change in gene transcription.

    abstract::Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Halley-Stott RP,Jullien J,Pasque V,Gurdon J

    更新日期:2014-07-29 00:00:00

  • The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity.

    abstract::The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: El-Athman R,Genov NN,Mazuch J,Zhang K,Yu Y,Fuhr L,Abreu M,Li Y,Wallach T,Kramer A,Schmitt CA,Relógio A

    更新日期:2017-12-07 00:00:00

  • Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.

    abstract::Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Duveau F,Félix MA

    更新日期:2012-01-01 00:00:00

  • GPCRs Direct Germline Development and Somatic Gonad Function in Planarians.

    abstract::Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GPCRs) in this dynamic germline regulation. By genome-enabled receptor ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Saberi A,Jamal A,Beets I,Schoofs L,Newmark PA

    更新日期:2016-05-10 00:00:00

  • Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation.

    abstract::Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

    更新日期:2020-10-05 00:00:00

  • Shellfish dredging pushes a flexible avian top predator out of a marine protected area.

    abstract::There is a widespread concern about the direct and indirect effects of industrial fisheries; this concern is particularly pertinent for so-called "marine protected areas" (MPAs), which should be safeguarded by national and international law. The intertidal flats of the Dutch Wadden Sea are a State Nature Monument and ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: van Gils JA,Piersma T,Dekinga A,Spaans B,Kraan C

    更新日期:2006-11-01 00:00:00

  • Structural studies of the giant mimivirus.

    abstract::Mimivirus is the largest known virus whose genome and physical size are comparable to some small bacteria, blurring the boundary between a virus and a cell. Structural studies of Mimivirus have been difficult because of its size and long surface fibers. Here we report the use of enzymatic digestions to remove the surf...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Xiao C,Kuznetsov YG,Sun S,Hafenstein SL,Kostyuchenko VA,Chipman PR,Suzan-Monti M,Raoult D,McPherson A,Rossmann MG

    更新日期:2009-04-28 00:00:00

  • The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.

    abstract::The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Bossuyt W,De Geest N,Aerts S,Leenaerts I,Marynen P,Hassan BA

    更新日期:2009-02-24 00:00:00

  • Diverse modes of axon elaboration in the developing neocortex.

    abstract::The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Portera-Cailliau C,Weimer RM,De Paola V,Caroni P,Svoboda K

    更新日期:2005-08-01 00:00:00

  • The Grand Convergence: Closing the Divide between Public Health Funding and Global Health Needs.

    abstract::The Global Health 2035 report notes that the "grand convergence"--closure of the infectious, maternal, and child mortality gap between rich and poor countries--is dependent on research and development (R&D) of new drugs, vaccines, diagnostics, and other health tools. However, this convergence (and the R&D underpinning...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Moran M

    更新日期:2016-03-02 00:00:00

  • Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome.

    abstract::Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. He...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ni X,Zhang YE,Nègre N,Chen S,Long M,White KP

    更新日期:2012-01-01 00:00:00

  • A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections.

    abstract::Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ayres JS,Schneider DS

    更新日期:2008-12-09 00:00:00

  • Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity.

    abstract::The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway-Patched-Smoothened-Gli-has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though So...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Delloye-Bourgeois C,Gibert B,Rama N,Delcros JG,Gadot N,Scoazec JY,Krauss R,Bernet A,Mehlen P

    更新日期:2013-01-01 00:00:00

  • NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

    abstract::Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the d...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Liu P,Dodson M,Fang D,Chapman E,Zhang DD

    更新日期:2020-02-13 00:00:00

  • A bioenergetic basis for membrane divergence in archaea and bacteria.

    abstract::Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Sojo V,Pomiankowski A,Lane N

    更新日期:2014-08-12 00:00:00

  • Language evolution and complexity considerations: The no half-Merge fallacy.

    abstract::Recently, prominent theoretical linguists have argued for an explicit scenario for the evolution of the human language capacity on the basis of its computational properties. Concretely, the simplicity of a minimalist formulation of the operation Merge, which allows humans to recursively compute hierarchical relations ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Martins PT,Boeckx C

    更新日期:2019-11-27 00:00:00

  • Stratus not altocumulus: a new view of the yeast protein interaction network.

    abstract::Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, which is loosely defined as a cohort of proteins that perform a dedicated...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Batada NN,Reguly T,Breitkreutz A,Boucher L,Breitkreutz BJ,Hurst LD,Tyers M

    更新日期:2006-10-01 00:00:00