Abstract:
:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Richardson LAdoi
10.1371/journal.pbio.3000020subject
Has Abstractpub_date
2018-10-04 00:00:00pages
e3000020issue
10eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-18-00435journal_volume
16pub_type
评论,杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...
journal_title:PLoS biology
pub_type: 杂志文章,评审
doi:10.1371/journal.pbio.2006592
更新日期:2018-08-24 00:00:00
abstract::Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030031
更新日期:2005-02-01 00:00:00
abstract::The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000040
更新日期:2009-02-24 00:00:00
abstract::Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000786
更新日期:2020-11-06 00:00:00
abstract::In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate the molecular mechan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001795
更新日期:2014-02-25 00:00:00
abstract::Changes in the physical interaction between cis-regulatory DNA sequences and proteins drive the evolution of gene expression. However, it has proven difficult to accurately quantify evolutionary rates of such binding change or to estimate the relative effects of selection and drift in shaping the binding evolution. He...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001420
更新日期:2012-01-01 00:00:00
abstract::Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have designed synthetic "s...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000328
更新日期:2019-06-17 00:00:00
abstract::Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000927
更新日期:2020-10-14 00:00:00
abstract::Modern whole-organism genome analysis, in combination with biomass estimates, allows us to estimate a lower bound on the total information content in the biosphere: 5.3 × 1031 (±3.6 × 1031) megabases (Mb) of DNA. Given conservative estimates regarding DNA transcription rates, this information content suggests biospher...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002168
更新日期:2015-06-11 00:00:00
abstract::Synaptic plasticity is widely believed to constitute a key mechanism for modifying functional properties of neuronal networks. This belief implicitly implies, however, that synapses, when not driven to change their characteristics by physiologically relevant stimuli, will maintain these characteristics over time. How ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000136
更新日期:2009-06-23 00:00:00
abstract::DEAD-box helicase proteins accelerate folding and rearrangements of highly structured RNAs and RNA-protein complexes (RNPs) in many essential cellular processes. Although DEAD-box proteins have been shown to use ATP to unwind short RNA helices, it is not known how they disrupt RNA tertiary structure. Here, we use sing...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001981
更新日期:2014-10-28 00:00:00
abstract::Several strategies have been pursued to increase the extent of exon 7 inclusion during splicing of SMN2 (survival of motor neuron 2) transcripts, for eventual therapeutic use in spinal muscular atrophy (SMA), a genetic neuromuscular disease. Antisense oligonucleotides (ASOs) that target an exon or its flanking splice ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050073
更新日期:2007-04-01 00:00:00
abstract::Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000271
更新日期:2019-05-13 00:00:00
abstract::To complete cell division with high fidelity, cytokinesis must be coordinated with chromosome segregation. Mammalian Polo-like kinase 1, Plk1, may function as a critical link because it is required for chromosome segregation and establishment of the cleavage plane following anaphase onset. A central spindle-localized ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000110
更新日期:2009-05-05 00:00:00
abstract::Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding o...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003691
更新日期:2017-12-28 00:00:00
abstract::Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with one-carbon metabolism, serine biosynthesis, and cellular redox r...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002243
更新日期:2015-09-10 00:00:00
abstract::In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2000111
更新日期:2016-08-15 00:00:00
abstract::During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome-encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells. Thus-in the context of agonist treatment during IVF-these r...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000663
更新日期:2020-03-23 00:00:00
abstract::While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000284
更新日期:2019-05-20 00:00:00
abstract::Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000349
更新日期:2019-08-20 00:00:00
abstract::Self-incompatibility (SI) is the flowering plant reproductive system in which self pollen tube growth is inhibited, thereby preventing self-fertilization. SI has evolved independently in several different flowering plant lineages. In all Brassicaceae species in which the molecular basis of SI has been investigated in ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001560
更新日期:2013-01-01 00:00:00
abstract::The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006838
更新日期:2018-12-26 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040069
更新日期:2006-03-01 00:00:00
abstract::Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain l...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060272
更新日期:2008-11-11 00:00:00
abstract::No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002068
更新日期:2015-02-17 00:00:00
abstract::Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on the plasma lipidome in a large population cohort using advanced mach...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000443
更新日期:2019-10-18 00:00:00
abstract::The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002940
更新日期:2017-12-07 00:00:00
abstract::Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000127
更新日期:2016-11-30 00:00:00
abstract::Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006994
更新日期:2019-01-31 00:00:00
abstract::The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent progress in unraveling the role of STIM2 in Ca2+ signaling, the mechan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006898
更新日期:2018-11-16 00:00:00