Birds, blooms, and evolving diversity.


:In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits.


PLoS Biol


PLoS biology


Richardson LA




Has Abstract


2018-10-04 00:00:00














  • A novel unsupervised analysis of electrophysiological signals reveals new sleep substages in mice.

    abstract::Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

    更新日期:2018-05-29 00:00:00

  • Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure.

    abstract::Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Denk W,Horstmann H

    更新日期:2004-11-01 00:00:00

  • CEP290 is essential for the initiation of ciliary transition zone assembly.

    abstract::Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Wu Z,Pang N,Zhang Y,Chen H,Peng Y,Fu J,Wei Q

    更新日期:2020-12-28 00:00:00

  • Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.

    abstract::The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Hoang HD,Miller MA

    更新日期:2017-06-29 00:00:00

  • Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.

    abstract::RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs). RNA-induced silencing complexes (RISC) in human cells can be programmed by exogenously in...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Chu CY,Rana TM

    更新日期:2006-07-01 00:00:00

  • The cutaneous rabbit illusion affects human primary sensory cortex somatotopically.

    abstract::We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Blankenburg F,Ruff CC,Deichmann R,Rees G,Driver J

    更新日期:2006-03-01 00:00:00

  • Authentication: A Standard Problem or a Problem of Standards?

    abstract::Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

    journal_title:PLoS biology

    pub_type: 评论,杂志文章


    authors: Capes-Davis A,Neve RM

    更新日期:2016-06-14 00:00:00

  • Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

    abstract::Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Lozoya OA,Martinez-Reyes I,Wang T,Grenet D,Bushel P,Li J,Chandel N,Woychik RP,Santos JH

    更新日期:2018-04-18 00:00:00

  • A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.

    abstract::The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Herzig Y,Sharpe HJ,Elbaz Y,Munro S,Schuldiner M

    更新日期:2012-01-01 00:00:00

  • Alerting or Somnogenic Light: Pick Your Color.

    abstract::In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

    journal_title:PLoS biology

    pub_type: 评论,杂志文章


    authors: Bourgin P,Hubbard J

    更新日期:2016-08-15 00:00:00

  • A bioenergetic basis for membrane divergence in archaea and bacteria.

    abstract::Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Sojo V,Pomiankowski A,Lane N

    更新日期:2014-08-12 00:00:00

  • Commensal bacteria and essential amino acids control food choice behavior and reproduction.

    abstract::Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Leitão-Gonçalves R,Carvalho-Santos Z,Francisco AP,Fioreze GT,Anjos M,Baltazar C,Elias AP,Itskov PM,Piper MDW,Ribeiro C

    更新日期:2017-04-25 00:00:00

  • Flight speeds among bird species: allometric and phylogenetic effects.

    abstract::Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Alerstam T,Rosén M,Bäckman J,Ericson PG,Hellgren O

    更新日期:2007-08-01 00:00:00

  • Spire and Formin 2 synergize and antagonize in regulating actin assembly in meiosis by a ping-pong mechanism.

    abstract::In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate the molecular mechan...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Montaville P,Jégou A,Pernier J,Compper C,Guichard B,Mogessie B,Schuh M,Romet-Lemonne G,Carlier MF

    更新日期:2014-02-25 00:00:00

  • Patterns of smallpox mortality in London, England, over three centuries.

    abstract::Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Krylova O,Earn DJD

    更新日期:2020-12-21 00:00:00

  • Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans.

    abstract::Misalignment of the daily sleep-wake and fasting-feeding cycles with the endogenous circadian timing system is an inevitable consequence of night shift work and is associated with adverse metabolic health effects. However, a detailed characterisation of the effects of night shifts on 24-h rhythms in the metabolome is ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Kervezee L,Cermakian N,Boivin DB

    更新日期:2019-06-18 00:00:00

  • Representations of Value in the Brain: An Embarrassment of Riches?

    abstract::Over the past two decades, neuroscientists have increasingly turned their attention to the question of how the brain implements decisions between differently valued options. This emerging field, called neuroeconomics, has made quick progress in identifying a plethora of brain areas that track or are modulated by rewar...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Stott JJ,Redish AD

    更新日期:2015-06-18 00:00:00

  • Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.

    abstract::Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

    更新日期:2019-02-04 00:00:00

  • A new type of Na(+)-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif.

    abstract::The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

    更新日期:2013-01-01 00:00:00

  • Identification of FAM173B as a protein methyltransferase promoting chronic pain.

    abstract::Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Willemen HLDM,Kavelaars A,Prado J,Maas M,Versteeg S,Nellissen LJJ,Tromp J,Gonzalez Cano R,Zhou W,Jakobsson ME,Małecki J,Posthuma G,Habib AM,Heijnen CJ,Falnes PØ,Eijkelkamp N

    更新日期:2018-02-14 00:00:00

  • An unexpected sequence of events: mismatch detection in the human hippocampus.

    abstract::The ability to identify and react to novelty within the environment is fundamental to survival. Computational models emphasize the potential role of the hippocampus in novelty detection, its unique anatomical circuitry making it ideally suited to act as a comparator between past and present experience. The hippocampus...

    journal_title:PLoS biology

    pub_type: 杂志文章,随机对照试验


    authors: Kumaran D,Maguire EA

    更新日期:2006-11-01 00:00:00

  • Hyperexpansion of RNA Bacteriophage Diversity.

    abstract::Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we ident...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Krishnamurthy SR,Janowski AB,Zhao G,Barouch D,Wang D

    更新日期:2016-03-24 00:00:00

  • Host-parasite interactions and the evolution of gene expression.

    abstract::Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and p...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Nuismer SL,Otto SP

    更新日期:2005-07-01 00:00:00

  • MooSciTIC: Training of trainers in West African research and higher education.

    abstract::The MooSciTIC project is a capacity-building initiative targeting West African research scientists and higher education teachers. The project aimed to improve the self-reliance of researchers and upgrade research practices by providing on-site summer schools on trans-disciplinary topics such as scientific writing, com...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Atindehou M,Adéoti K,Loko LEY,Beulé T,Paradis E,Djedatin G,Tranchant-Dubreuil C,Sabot F,Lagnika L,Jaligot E

    更新日期:2019-06-07 00:00:00

  • Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes.

    abstract::Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this function...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Kushnareva Y,Andreyev AY,Kuwana T,Newmeyer DD

    更新日期:2012-01-01 00:00:00

  • Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.

    abstract::Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. These pathological fea...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Gallego-Delgado P,James R,Browne E,Meng J,Umashankar S,Tan L,Picon C,Mazarakis ND,Faisal AA,Howell OW,Reynolds R

    更新日期:2020-12-14 00:00:00

  • The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB.

    abstract::Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner R

    更新日期:2013-12-01 00:00:00

  • Identification of traits and functional connectivity-based neurotraits of chronic pain.

    abstract::Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional ...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Vachon-Presseau E,Berger SE,Abdullah TB,Griffith JW,Schnitzer TJ,Apkarian AV

    更新日期:2019-08-20 00:00:00

  • A simple genetic architecture underlies morphological variation in dogs.

    abstract::Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 sin...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Boyko AR,Quignon P,Li L,Schoenebeck JJ,Degenhardt JD,Lohmueller KE,Zhao K,Brisbin A,Parker HG,vonHoldt BM,Cargill M,Auton A,Reynolds A,Elkahloun AG,Castelhano M,Mosher DS,Sutter NB,Johnson GS,Novembre J,Hubisz MJ,

    更新日期:2010-08-10 00:00:00

  • Phosphatidylserine externalization, "necroptotic bodies" release, and phagocytosis during necroptosis.

    abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

    journal_title:PLoS biology

    pub_type: 杂志文章


    authors: Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

    更新日期:2017-06-26 00:00:00