Abstract:
:In an age of free international shipments of mail-ordered seeds and plants, more policing will not stop the global migration of hitchhiking pests. The solution is in a preemptive response based on an internationally coordinated genomic deployment of global biodiversity in the largest breeding project since the "Garden of Eden." This plan will enrich the narrow genetic basis of annual and perennial plants with adaptations to changing environments and resistances to the pests of the future.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Zamir Ddoi
10.1371/journal.pbio.1002438subject
Has Abstractpub_date
2016-04-19 00:00:00pages
e1002438issue
4eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-15-03164journal_volume
14pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent results ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000856
更新日期:2020-09-17 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040069
更新日期:2006-03-01 00:00:00
abstract::Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000245
更新日期:2017-03-10 00:00:00
abstract::Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001029
更新日期:2021-01-04 00:00:00
abstract::Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments. In metazoans, monomeric actin polymerises into usually long and stable filaments, while some protozoans form only short and highly dynamic actin filaments. These different dynamics are partl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005345
更新日期:2018-07-16 00:00:00
abstract::The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmental organization of the vertebrate central nervous system. In the hindbrain and spinal cord, distinctions in the rostrocaudal identity of progenitor cells are associated with the generation of ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040252
更新日期:2006-07-01 00:00:00
abstract::Cancer research has become a global enterprise, and the number of researchers, as well as the cost for their activities, has skyrocketed. The budget for the National Cancer Institute of the United States National Institutes of Health alone was US$5.2 billion in 2015. Since most of the research is funded by public mone...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000314
更新日期:2016-09-29 00:00:00
abstract::Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050197
更新日期:2007-08-01 00:00:00
abstract::This speculative Essay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided evidence that genes are made of DNA. Four imaginary alternate routes to the genetic function of DNA are outlined, each of which highlights different aspects of the actual process of discovery. ...
journal_title:PLoS biology
pub_type: 传,历史文章,杂志文章
doi:10.1371/journal.pbio.2001197
更新日期:2016-12-22 00:00:00
abstract::Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm for the generation of vascularized organoids (vOrganoids) consis...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000705
更新日期:2020-05-13 00:00:00
abstract::The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phen...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030101
更新日期:2005-04-01 00:00:00
abstract::Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005019
更新日期:2018-04-16 00:00:00
abstract::Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030225
更新日期:2005-07-01 00:00:00
abstract::The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a uniqu...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000576
更新日期:2020-02-11 00:00:00
abstract::Sensory loss induces cross-modal plasticity, often resulting in altered performance in remaining sensory modalities. Whereas much is known about the macroscopic mechanisms underlying cross-modal plasticity, only scant information exists about its cellular and molecular underpinnings. We found that Caenorhabditis elega...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002348
更新日期:2016-01-08 00:00:00
abstract::Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030298
更新日期:2005-09-01 00:00:00
abstract::Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/TFE family of transc...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000245
更新日期:2019-05-14 00:00:00
abstract::A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000677
更新日期:2020-06-12 00:00:00
abstract::Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002262
更新日期:2015-09-17 00:00:00
abstract::The recent United States measles epidemic has sparked another contentious national discussion about childhood vaccination. A growing number of parents are expressing concerns about the safety of vaccines, often fueled by misinformation from the internet, books, and other nonmedical sources. Many of these concerned par...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002227
更新日期:2015-08-07 00:00:00
abstract::Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment remains unclear. From previous studies, the parasites that cause...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004328
更新日期:2018-03-12 00:00:00
abstract::Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0000035
更新日期:2003-11-01 00:00:00
abstract::microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to precursor miRNA (pre-m...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030236
更新日期:2005-07-01 00:00:00
abstract::Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000121
更新日期:2009-06-02 00:00:00
abstract::Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The female-specific neo-W chromosome of the African monarch (or queen) butterfly Danaus chrysippus presents an intriguing case study because it is restricted to a single 'contact zone' population, invol...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000610
更新日期:2020-02-27 00:00:00
abstract::Malaria transmission is known to be strongly impacted by temperature. The current understanding of how temperature affects mosquito and parasite life history traits derives from a limited number of empirical studies. These studies, some dating back to the early part of last century, are often poorly controlled, have l...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003489
更新日期:2017-10-16 00:00:00
abstract::There is a widespread concern about the direct and indirect effects of industrial fisheries; this concern is particularly pertinent for so-called "marine protected areas" (MPAs), which should be safeguarded by national and international law. The intertidal flats of the Dutch Wadden Sea are a State Nature Monument and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040376
更新日期:2006-11-01 00:00:00
abstract::Movements overtly sample sensory information, making sensory analysis an active-sensing process. In this study, we show that visual information sampling is not just locked to the (overt) movement dynamics but to the internal (covert) dynamics of cortico-motor control. We asked human participants to perform continuous ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000898
更新日期:2020-10-20 00:00:00
abstract::Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002419
更新日期:2016-03-25 00:00:00
abstract::The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020203
更新日期:2004-08-01 00:00:00