Abstract:
:The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep deprived. Agents capable of improving cognition by enhancing brain activity under normal circumstances may also have the potential to reduce the harmful or unwanted effects of sleep deprivation. The significant prevalence of excitatory alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamatergic receptors in the brain provides a basis for implementing a class of drugs that could act to alter or remove the effects of sleep deprivation. The ampakine CX717 (Cortex Pharmaceuticals), a positive allosteric modulator of AMPA receptors, was tested for its ability to enhance performance of a cognitive, delayed match-to-sample task under normal circumstances in well-trained monkeys, as well as alleviate the detrimental effects of 30-36 h of sleep deprivation. CX717 produced a dose-dependent enhancement of task performance under normal alert testing conditions. Concomitant measures of regional cerebral metabolic rates for glucose (CMRglc) during the task, utilizing positron emission tomography, revealed increased activity in prefrontal cortex, dorsal striatum, and medial temporal lobe (including hippocampus) that was significantly enhanced over normal alert conditions following administration of CX717. A single night of sleep deprivation produced severe impairments in performance in the same monkeys, accompanied by significant alterations in task-related CMRglc in these same brain regions. However, CX717 administered to sleep-deprived monkeys produced a striking removal of the behavioral impairment and returned performance to above-normal levels even though animals were sleep deprived. Consistent with this recovery, CMRglc in all but one brain region affected by sleep deprivation was also returned to the normal alert pattern by the drug. The ampakine CX717, in addition to enhancing cognitive performance under normal alert conditions, also proved effective in alleviating impairment of performance due to sleep deprivation. Therefore, the ability to activate specific brain regions under normal alert conditions and alter the deleterious effects of sleep deprivation on activity in those same regions indicate a potential role for ampakines in sustaining performance under these types of adverse conditions.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Porrino LJ,Daunais JB,Rogers GA,Hampson RE,Deadwyler SAdoi
10.1371/journal.pbio.0030299keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
e299issue
9eissn
1544-9173issn
1545-7885pii
05-PLBI-RA-0261R2journal_volume
3pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter dogs across 60,968 sin...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000451
更新日期:2010-08-10 00:00:00
abstract::Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005019
更新日期:2018-04-16 00:00:00
abstract::Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001082
更新日期:2011-06-01 00:00:00
abstract::Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000184
更新日期:2019-03-28 00:00:00
abstract::CD45(+):Sca1(+) adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD. By contrast, CD45(+):Sca1(+) isolated from injured Pax7( ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020130
更新日期:2004-05-01 00:00:00
abstract::The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040127
更新日期:2006-05-01 00:00:00
abstract::Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020303
更新日期:2004-10-01 00:00:00
abstract::Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the sequence of the nasc...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2001882
更新日期:2017-03-21 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.2001154.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002604
更新日期:2017-05-09 00:00:00
abstract::The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002458
更新日期:2016-05-06 00:00:00
abstract::Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005707
更新日期:2018-04-18 00:00:00
abstract::Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060278
更新日期:2008-11-18 00:00:00
abstract::Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in local zinc concentration. To understand how microorganisms coordinate a dynamic response to changes in zinc availability at the molecular level, we evaluated the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001987
更新日期:2014-11-04 00:00:00
abstract::We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004408
更新日期:2018-06-21 00:00:00
abstract::Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000493
更新日期:2019-11-05 00:00:00
abstract::Alpha thalassemia/mental retardation syndrome X-linked chromatin remodeler (ATRX), a DAXX (death domain-associated protein) interacting protein, is often lost in cells using the alternative lengthening of telomeres (ALT) pathway, but it is not known how ATRX loss leads to ALT. We report that ATRX deletion from mouse c...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000594
更新日期:2020-01-02 00:00:00
abstract::Munc18-1, a protein essential for regulated exocytosis in neurons and neuroendocrine cells, belongs to the family of Sec1/Munc18-like (SM) proteins. In vitro, Munc18-1 forms a tight complex with the SNARE syntaxin 1, in which syntaxin is stabilized in a closed conformation. Since closed syntaxin is unable to interact ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040330
更新日期:2006-10-01 00:00:00
abstract::Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000125
更新日期:2019-01-29 00:00:00
abstract::Next generation sequencing (NGS) technologies are being used to generate whole genome sequences for a wide range of crop species. When combined with precise phenotyping methods, these technologies provide a powerful and rapid tool for identifying the genetic basis of agriculturally important traits and for predicting ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001883
更新日期:2014-06-10 00:00:00
abstract::Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002226
更新日期:2018-01-04 00:00:00
abstract::Pseudomonas aeruginosa is an opportunistic pathogen that often infects open wounds or patients with cystic fibrosis. Once established, P. aeruginosa infections are notoriously difficult to eradicate. This difficulty is in part due to the ability of P. aeruginosa to tolerate antibiotic treatment at the individual-cell ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000573
更新日期:2019-12-16 00:00:00
abstract::Contemporary science thrives on collaborative networks, but these can also be found elsewhere in the history of science in unexpected places. When Mendel turned his attention to inheritance in peas he was not an isolated monk, but rather the latest in a line of Moravian researchers and agriculturalists who had been th...
journal_title:PLoS biology
pub_type: 历史文章,杂志文章
doi:10.1371/journal.pbio.1001772
更新日期:2014-01-01 00:00:00
abstract::Transposable elements comprise a huge portion of most animal genomes. Unlike many pathogens, these elements leave a mark of their impact via their insertion into host genomes. With proper teasing, these sequences can relay information about the evolutionary history of transposons and their hosts. In a new publication,...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2005470
更新日期:2018-03-05 00:00:00
abstract::Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001750
更新日期:2013-12-01 00:00:00
abstract::There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo. Here, by using the multi-protein tip complex of the mannose-binding type 1 fimb...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000617
更新日期:2011-05-01 00:00:00
abstract::The array of vibrissae on a rat's face is the first stage in a high-resolution tactile sensing system. Progressing from rostral to caudal in any vibrissae row results in an increase in whisker length and thickness. This may, in turn, provide a systematic map of separate tactile channels governed by the mechanical prop...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000699
更新日期:2020-10-22 00:00:00
abstract::The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030067
更新日期:2005-03-01 00:00:00
abstract::A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002118
更新日期:2015-04-09 00:00:00
abstract::We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000583
更新日期:2020-01-23 00:00:00
abstract::The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000546
更新日期:2019-12-09 00:00:00