Abstract:
:What do "microbes" have to do with social equity? These microorganisms are integral to our health, that of our natural environment, and even the "health" of the environments we build. The loss, gain, and retention of microorganisms-their flow between humans and the environment-can greatly impact our health. It is well-known that inequalities in access to perinatal care, healthy foods, quality housing, and the natural environment can create and arise from social inequality. Here, we focus on the argument that access to beneficial microorganisms is a facet of public health, and health inequality may be compounded by inequitable microbial exposure.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Ishaq SL,Rapp M,Byerly R,McClellan LS,O'Boyle MR,Nykanen A,Fuller PJ,Aas C,Stone JM,Killpatrick S,Uptegrove MM,Vischer A,Wolf H,Smallman F,Eymann H,Narode S,Stapleton E,Cioffi CC,Tavalire HFdoi
10.1371/journal.pbio.3000536subject
Has Abstractpub_date
2019-11-26 00:00:00pages
e3000536issue
11eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-19-02508journal_volume
17pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to iden...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2000080
更新日期:2017-01-06 00:00:00
abstract::Do neuronal oscillations play a causal role in brain function? In a study in this issue of PLOS Biology, Helfrich and colleagues address this long-standing question by attempting to drive brain oscillations using transcranial electrical current stimulation. Remarkably, they were able to manipulate visual perception by...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1002032
更新日期:2014-12-30 00:00:00
abstract::A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003805
更新日期:2018-08-15 00:00:00
abstract::Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000087
更新日期:2019-09-03 00:00:00
abstract::The functional consequences of long-range nuclear reorganization were studied in a cell-by-cell analysis of gene expression and long-range chromosomal interactions in the Drosophila eye and eye imaginal disk. Position-effect variegation was used to stochastically perturb gene expression and probe nuclear reorganizatio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030067
更新日期:2005-03-01 00:00:00
abstract::Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005019
更新日期:2018-04-16 00:00:00
abstract::Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060084
更新日期:2008-04-08 00:00:00
abstract::Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in local zinc concentration. To understand how microorganisms coordinate a dynamic response to changes in zinc availability at the molecular level, we evaluated the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001987
更新日期:2014-11-04 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002436.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002494
更新日期:2016-06-08 00:00:00
abstract::This speculative Essay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided evidence that genes are made of DNA. Four imaginary alternate routes to the genetic function of DNA are outlined, each of which highlights different aspects of the actual process of discovery. ...
journal_title:PLoS biology
pub_type: 传,历史文章,杂志文章
doi:10.1371/journal.pbio.2001197
更新日期:2016-12-22 00:00:00
abstract::Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitochondrial outer membrane (MOM) proteins might facilitate this function...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001394
更新日期:2012-01-01 00:00:00
abstract::This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing. ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000342
更新日期:2010-03-23 00:00:00
abstract::FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important functions in devel...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001586
更新日期:2013-01-01 00:00:00
abstract::5-hydroxymethylcytosine (5hmC) is the most prevalent intermediate on the oxidative DNA demethylation pathway and is implicated in regulation of embryogenesis, neurological processes, and cancerogenesis. Profiling of this relatively scarce genomic modification in clinical samples requires cost-effective high-resolution...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000684
更新日期:2020-04-10 00:00:00
abstract::Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000181
更新日期:2019-10-01 00:00:00
abstract::The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000876
更新日期:2020-11-18 00:00:00
abstract::Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000506
更新日期:2020-12-21 00:00:00
abstract::Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000121
更新日期:2009-06-02 00:00:00
abstract::Ever since the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regeneration has captured the minds of scientists, clinicians, and the public. Neural stem cells have been envisioned as a source of donor cells for transplantation and vectors for the delivery of gene therapy. Over t...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002329
更新日期:2017-05-15 00:00:00
abstract::Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001808
更新日期:2014-03-11 00:00:00
abstract::The signals that initiate cell invasion are not well understood, but there is increasing evidence that extracellular physical signals play an important role. Here we show that epithelial cell invasion in the intestine of zebrafish meltdown (mlt) mutants arises in response to unregulated contractile tone in the surroun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001386
更新日期:2012-01-01 00:00:00
abstract::We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modulated by substitutin...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060234
更新日期:2008-09-30 00:00:00
abstract::Microbial dysbiosis in the upper digestive tract is linked to an increased risk of esophageal squamous cell carcinoma (ESCC). Overabundance of Porphyromonas gingivalis is associated with shorter survival of ESCC patients. We investigated the molecular mechanisms driving aggressive progression of ESCC by P. gingivalis....
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000825
更新日期:2020-09-04 00:00:00
abstract::The intrinsic flexibility of proteins allows them to undergo large conformational fluctuations in solution or upon interaction with other molecules. Proteins also commonly assemble into complexes with diverse quaternary structure arrangements. Here we investigate how the flexibility of individual protein chains influe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001870
更新日期:2014-05-27 00:00:00
abstract::Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in neural coding and modulates information transfer between cortic...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004132
更新日期:2018-05-31 00:00:00
abstract::Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005707
更新日期:2018-04-18 00:00:00
abstract::Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000271
更新日期:2019-05-13 00:00:00
abstract::RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs). RNA-induced silencing complexes (RISC) in human cells can be programmed by exogenously in...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040210
更新日期:2006-07-01 00:00:00
abstract::Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000927
更新日期:2020-10-14 00:00:00
abstract::Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3001029
更新日期:2021-01-04 00:00:00