Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing.

abstract：:Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on...

journal_title：PLoS biology

authors： Crawley D,Zhang L,Jones EJH,Ahmad J,Oakley B,San José Cáceres A,Charman T,Buitelaar JK,Murphy DGM,Chatham C,den Ouden H,Loth E,EU-AIMS LEAP group.

更新日期：2020-10-27 00:00:00

abstract：:The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y...

journal_title：PLoS biology

authors： Boutin P,Dina C,Vasseur F,Dubois S,Corset L,Séron K,Bekris L,Cabellon J,Neve B,Vasseur-Delannoy V,Chikri M,Charles MA,Clement K,Lernmark A,Froguel P

更新日期：2003-12-01 00:00:00

abstract：:Unc-51-like autophagy activating kinase 1 (ULK1)-autophagy-related 13 (ATG13) is the most upstream autophagy initiation complex that is phosphorylated by mammalian target-of-rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK) to induce autophagy in asynchronous conditions. However, their phospho-regul...

journal_title：PLoS biology

authors： Li Z,Tian X,Ji X,Wang J,Chen H,Wang D,Zhang X

更新日期：2020-06-09 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000193.]. ...

journal_title：PLoS biology

authors： Field KA,Paquet PC,Artelle K,Proulx G,Brook RK,Darimont CT

更新日期：2020-05-18 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...

journal_title：PLoS biology

authors： Moore JD,Mercer Lindsay N,Deschênes M,Kleinfeld D

更新日期：2015-09-22 00:00:00

abstract：:Modern whole-organism genome analysis, in combination with biomass estimates, allows us to estimate a lower bound on the total information content in the biosphere: 5.3 × 1031 (±3.6 × 1031) megabases (Mb) of DNA. Given conservative estimates regarding DNA transcription rates, this information content suggests biospher...

journal_title：PLoS biology

authors： Landenmark HK,Forgan DH,Cockell CS

更新日期：2015-06-11 00:00:00

abstract：:Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned P...

journal_title：PLoS biology

authors： Valdés-Baizabal C,Carbajal GV,Pérez-González D,Malmierca MS

更新日期：2020-06-19 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:During quiet resting behavior, involuntary movements are suppressed. Such movement control is attributed to cortico-basal ganglia loops, yet population dynamics within these loops during resting and their relation to involuntary movements are not well characterized. Here, we show by recording cortical and striatal ong...

journal_title：PLoS biology

authors： Klaus A,Plenz D

更新日期：2016-12-06 00:00:00

abstract：:The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...

journal_title：PLoS biology

authors： Kalinovsky A,Boukhtouche F,Blazeski R,Bornmann C,Suzuki N,Mason CA,Scheiffele P

更新日期：2011-02-08 00:00:00

abstract：:Progress in science often begins with verbal hypotheses meant to explain why certain biological phenomena exist. An important purpose of mathematical models in evolutionary research, as in many other fields, is to act as “proof-of-concept” tests of the logic in verbal explanations, paralleling the way in which empiric...

journal_title：PLoS biology

authors： Servedio MR,Brandvain Y,Dhole S,Fitzpatrick CL,Goldberg EE,Stern CA,Van Cleve J,Yeh DJ

更新日期：2014-12-09 00:00:00

abstract：:The development of axonal arbors is a critical step in the establishment of precise neural circuits, but relatively little is known about the mechanisms of axonal elaboration in the neocortex. We used in vivo two-photon time-lapse microscopy to image axons in the neocortex of green fluorescent protein-transgenic mice ...

journal_title：PLoS biology

authors： Portera-Cailliau C,Weimer RM,De Paola V,Caroni P,Svoboda K

更新日期：2005-08-01 00:00:00

abstract：:Organisms evolve two routes to surviving infections-they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two properties together defines the defensive capabilities of the host. Typically, studies of animal defenses focus on either understanding re...

journal_title：PLoS biology

authors： Ayres JS,Schneider DS

更新日期：2008-12-09 00:00:00

abstract：:When one finger touches the other, the resulting tactile sensation is perceived as weaker than the same stimulus externally imposed. This attenuation of sensation could result from a predictive process that subtracts the expected sensory consequences of the action, or from a postdictive process that alters the percept...

journal_title：PLoS biology

authors： Bays PM,Flanagan JR,Wolpert DM

更新日期：2006-02-01 00:00:00

abstract：:Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalami...

journal_title：PLoS biology

authors： Schwab BC,Kase D,Zimnik A,Rosenbaum R,Codianni MG,Rubin JE,Turner RS

更新日期：2020-10-13 00:00:00

abstract：:The maintenance of pluripotency and specification of cellular lineages during embryonic development are controlled by transcriptional regulatory networks, which coordinate specific sets of genes through both activation and repression. The transcriptional repressor RE1-silencing transcription factor (REST) plays import...

journal_title：PLoS biology

authors： Johnson R,Teh CH,Kunarso G,Wong KY,Srinivasan G,Cooper ML,Volta M,Chan SS,Lipovich L,Pollard SM,Karuturi RK,Wei CL,Buckley NJ,Stanton LW

更新日期：2008-10-28 00:00:00

abstract：:Certain bacterial adhesins appear to promote a pathogen's extracellular lifestyle rather than its entry into host cells. However, little is known about the stimuli elicited upon such pathogen host-cell interactions. Here, we report that type IV pili (Tfp)-producing Neisseria gonorrhoeae (P(+)GC) induces an immediate r...

journal_title：PLoS biology

authors： Boettcher JP,Kirchner M,Churin Y,Kaushansky A,Pompaiah M,Thorn H,Brinkmann V,Macbeath G,Meyer TF

更新日期：2010-08-24 00:00:00

abstract：:Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...

journal_title：PLoS biology

authors： Gretenkord S,Kostka JK,Hartung H,Watznauer K,Fleck D,Minier-Toribio A,Spehr M,Hanganu-Opatz IL

更新日期：2019-01-31 00:00:00

abstract：:Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing ICAN is predicted to slow down or stop breathing; its contributions to motor patt...

journal_title：PLoS biology

authors： Picardo MCD,Sugimura YK,Dorst KE,Kallurkar PS,Akins VT,Ma X,Teruyama R,Guinamard R,Kam K,Saha MS,Del Negro CA

更新日期：2019-02-21 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Here, we have used a graph theory-based systems biology approach to dete...

journal_title：PLoS biology

authors： Novkovic M,Onder L,Cupovic J,Abe J,Bomze D,Cremasco V,Scandella E,Stein JV,Bocharov G,Turley SJ,Ludewig B

更新日期：2016-07-14 00:00:00

abstract：:The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

journal_title：PLoS biology

authors： Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

更新日期：2013-01-01 00:00:00

abstract：:Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown. We found that adipocytes require Cu to establish a balance between main metabolic fuels. Differentiating adipocytes increase their Cu uptake along with the ATP7...

journal_title：PLoS biology

authors： Yang H,Ralle M,Wolfgang MJ,Dhawan N,Burkhead JL,Rodriguez S,Kaplan JH,Wong GW,Haughey N,Lutsenko S

更新日期：2018-09-10 00:00:00

abstract：:There is currently a demand for new highly efficient and specific drugs to treat osteoporosis, a chronic bone disease affecting millions of people worldwide. We have developed a combinatorial strategy for engineering bispecific inhibitors that simultaneously target the unique combination of c-FMS and αvβ3 integrin, wh...

journal_title：PLoS biology

authors： Zur Y,Rosenfeld L,Keshelman CA,Dalal N,Guterman-Ram G,Orenbuch A,Einav Y,Levaot N,Papo N

更新日期：2018-08-24 00:00:00

abstract：:Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions that regulate the act...

journal_title：PLoS biology

authors： Meharena HS,Fan X,Ahuja LG,Keshwani MM,McClendon CL,Chen AM,Adams JA,Taylor SS

更新日期：2016-11-30 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:Neuronal migration during embryonic development contributes to functional brain circuitry. Many neurons migrate in morphologically distinct stages that coincide with differentiation, requiring tight spatial regulation. It had been proposed that neurotransmitter-mediated activity could exert this control. Here, we demo...

journal_title：PLoS biology

authors： Theisen U,Hennig C,Ring T,Schnabel R,Köster RW

更新日期：2018-01-04 00:00:00

abstract：:Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain l...

journal_title：PLoS biology

authors： Jessberger S,Aigner S,Clemenson GD Jr,Toni N,Lie DC,Karalay O,Overall R,Kempermann G,Gage FH

更新日期：2008-11-11 00:00:00

abstract：:How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance--the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively we...

journal_title：PLoS biology

authors： Råberg L

更新日期：2014-11-04 00:00:00