Abstract:
:Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain largely unknown. Here we show that single-cell-specific knockdown of cyclin-dependent kinase 5 (cdk5) activity in newborn cells using a retrovirus-based strategy leads to aberrant growth of dendritic processes, which is associated with an altered migration pattern of newborn cells. Even though spine formation and maturation are reduced in cdk5-deficient cells, aberrant dendrites form ectopic synapses onto hilar neurons. These observations identify cdk5 to be critically involved in the maturation and dendrite extension of newborn neurons in the course of adult neurogenesis. The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Jessberger S,Aigner S,Clemenson GD Jr,Toni N,Lie DC,Karalay O,Overall R,Kempermann G,Gage FHdoi
10.1371/journal.pbio.0060272subject
Has Abstractpub_date
2008-11-11 00:00:00pages
e272issue
11eissn
1544-9173issn
1545-7885pii
08-PLBI-RA-2595journal_volume
6pub_type
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