Abstract:
:Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, in this study we show that progressive mitochondrial dysfunction leads to an early transcriptional and metabolic program centered on the metabolism of various amino acids, including those involved in the methionine cycle. We find that this program also increases DNA methylation, which occurs primarily in the genes that are differentially expressed. Maintenance of mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation in the context of mtDNA loss rescues methionine salvage and polyamine synthesis and prevents changes in DNA methylation and gene expression but does not affect serine/folate metabolism or transsulfuration. This work provides a novel mechanistic link between mitochondrial function and epigenetic regulation of gene expression that involves polyamine and methionine metabolism responding to changes in the tricarboxylic acid (TCA) cycle. Given the implications of these findings, future studies across different physiological contexts and in vivo are warranted.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Lozoya OA,Martinez-Reyes I,Wang T,Grenet D,Bushel P,Li J,Chandel N,Woychik RP,Santos JHdoi
10.1371/journal.pbio.2005707subject
Has Abstractpub_date
2018-04-18 00:00:00pages
e2005707issue
4eissn
1544-9173issn
1545-7885pii
pbio.2005707journal_volume
16pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001666
更新日期:2013-09-01 00:00:00
abstract::How cell proliferation subsides as cells terminally differentiate remains largely enigmatic, although this phenomenon is central to the existence of multicellular organisms. Here, we show that GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2....
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000123
更新日期:2009-06-09 00:00:00
abstract::Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050012
更新日期:2007-01-01 00:00:00
abstract::Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than other cells and might t...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060253
更新日期:2008-10-21 00:00:00
abstract::In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.2000111
更新日期:2016-08-15 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002125.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002163
更新日期:2015-05-14 00:00:00
abstract::Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, which is loosely defined as a cohort of proteins that perform a dedicated...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040317
更新日期:2006-10-01 00:00:00
abstract::Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to the autosomes. It has been proposed that inactivation of the X ch...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050273
更新日期:2007-10-01 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to study neural correlates of a robust somatosensory illusion that can dissociate tactile perception from physical stimulation. Repeated rapid stimulation at the wrist, then near the elbow, can create the illusion of touches at intervening locations along the arm, a...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040069
更新日期:2006-03-01 00:00:00
abstract::The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001329
更新日期:2012-01-01 00:00:00
abstract::All organisms live in temporally fluctuating environments. Theory predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plasticity) underlies adaptation to environments that fluctuate in a predictably alternating fashion over maternal-offspri...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002388
更新日期:2016-02-24 00:00:00
abstract::Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalam...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001112
更新日期:2011-07-01 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pbio.1002436.]. ...
journal_title:PLoS biology
pub_type: 已发布勘误
doi:10.1371/journal.pbio.1002494
更新日期:2016-06-08 00:00:00
abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002711
更新日期:2017-06-26 00:00:00
abstract::Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without crea...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005019
更新日期:2018-04-16 00:00:00
abstract::Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000086
更新日期:2009-04-07 00:00:00
abstract::The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040127
更新日期:2006-05-01 00:00:00
abstract::Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040417
更新日期:2006-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent progress in unraveling the role of STIM2 in Ca2+ signaling, the mechan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006898
更新日期:2018-11-16 00:00:00
abstract::While multiple studies have reported the accelerated evolution of brain gene expression in the human lineage, the mechanisms underlying such changes are unknown. Here, we address this issue from a developmental perspective, by analyzing mRNA and microRNA (miRNA) expression in two brain regions within macaques, chimpan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001214
更新日期:2011-12-01 00:00:00
abstract::The source of symmetry breaking in vertebrate oocytes is unknown. Animal-vegetal oocyte polarity is established by the Balbiani body (Bb), a conserved structure found in all animals examined that contains an aggregate of specific mRNAs, proteins, and organelles. The Bb specifies the oocyte vegetal pole, which is key t...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002335
更新日期:2016-01-07 00:00:00
abstract::A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005952
更新日期:2018-11-01 00:00:00
abstract::The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. H...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020261
更新日期:2004-09-01 00:00:00
abstract::Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to students in classrooms is challenging because of the need to form partnerships w...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000668
更新日期:2020-03-30 00:00:00
abstract::Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050210
更新日期:2007-08-01 00:00:00
abstract::In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005561
更新日期:2018-11-28 00:00:00
abstract::Flight speed is expected to increase with mass and wing loading among flying animals and aircraft for fundamental aerodynamic reasons. Assuming geometrical and dynamical similarity, cruising flight speed is predicted to vary as (body mass)(1/6) and (wing loading)(1/2) among bird species. To test these scaling rules an...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050197
更新日期:2007-08-01 00:00:00
abstract::Members of the highly conserved class of BEACH domain containing proteins (BDCPs) have been established as broad facilitators of protein-protein interactions and membrane dynamics in the context of human diseases like albinism, bleeding diathesis, impaired cellular immunity, cancer predisposition, and neurological dys...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002188
更新日期:2015-07-02 00:00:00
abstract::Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002009
更新日期:2014-12-02 00:00:00
abstract:UNLABELLED:Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being reward...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000164
更新日期:2009-07-01 00:00:00