Genetic control of organ shape and tissue polarity.

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00

abstract：:The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...

journal_title：PLoS biology

authors： Silva EA,Des Jarlais C,Lindstaedt B,Rotman E,Watkins ES

更新日期：2016-05-06 00:00:00

abstract：:Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex I are involved in a wide range of degenerative disorders. Recent...

journal_title：PLoS biology

authors： Dröse S,Krack S,Sokolova L,Zwicker K,Barth HD,Morgner N,Heide H,Steger M,Nübel E,Zickermann V,Kerscher S,Brutschy B,Radermacher M,Brandt U

更新日期：2011-08-01 00:00:00

abstract：:Glial cells surround neuronal endings to create enclosed compartments required for neuronal function. This architecture is seen at excitatory synapses and at sensory neuron receptive endings. Despite the prevalence and importance of these compartments, how they form is not known. We used the main sensory organ of C. e...

journal_title：PLoS biology

authors： Oikonomou G,Perens EA,Lu Y,Watanabe S,Jorgensen EM,Shaham S

更新日期：2011-08-01 00:00:00

abstract：:The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately improved by analytical work, whether ensuring reproducible and well-document...

journal_title：PLoS biology

authors： Kucharski AJ,Funk S,Eggo RM

更新日期：2020-10-16 00:00:00

abstract：:Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated. Mortality from smallpox in London, England was carefully documented, weekly, for nearly 300 years, providing a rare and ...

journal_title：PLoS biology

authors： Krylova O,Earn DJD

更新日期：2020-12-21 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:Do malaria parasites enhance the attractiveness of humans to the parasite's vector? As such manipulation would have important implications for the epidemiology of the disease, the question has been debated for many years. To investigate the issue in a semi-natural situation, we assayed the attractiveness of 12 groups ...

journal_title：PLoS biology

authors： Lacroix R,Mukabana WR,Gouagna LC,Koella JC

更新日期：2005-09-01 00:00:00

abstract：:While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstru...

journal_title：PLoS biology

authors： Paquola C,Vos De Wael R,Wagstyl K,Bethlehem RAI,Hong SJ,Seidlitz J,Bullmore ET,Evans AC,Misic B,Margulies DS,Smallwood J,Bernhardt BC

更新日期：2019-05-20 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:A substantial proportion of protein interactions relies on small domains binding to short peptides in the partner proteins. Many of these interactions are relatively low affinity and transient, and they impact on signal transduction. However, neither the number of potential interactions mediated by each domain nor the...

journal_title：PLoS biology

authors： Landgraf C,Panni S,Montecchi-Palazzi L,Castagnoli L,Schneider-Mergener J,Volkmer-Engert R,Cesareni G

更新日期：2004-01-01 00:00:00

abstract：:Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We examined two tumors with fibroblastic features, solitary fibrous tumo...

journal_title：PLoS biology

authors： West RB,Nuyten DS,Subramanian S,Nielsen TO,Corless CL,Rubin BP,Montgomery K,Zhu S,Patel R,Hernandez-Boussard T,Goldblum JR,Brown PO,van de Vijver M,van de Rijn M

更新日期：2005-06-01 00:00:00

abstract：:Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...

journal_title：PLoS biology

authors： Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner R

更新日期：2013-12-01 00:00:00

abstract：:The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the mature organ. During organogenesis, the epithelial cells receive essential signals from the overlying mesenchyme. Previous studies, focusing on ex vivo tissue explants or complete knockout mice, have identified an important role...

journal_title：PLoS biology

authors： Landsman L,Nijagal A,Whitchurch TJ,Vanderlaan RL,Zimmer WE,Mackenzie TC,Hebrok M

更新日期：2011-09-01 00:00:00

abstract：:We used a class of designed peptide detergents to stabilize photosystem I (PS-I) upon extended drying under N2 on a gold-coated-Ni-NTA glass surface. PS-I is a chlorophyll-containing membrane protein complex that is the primary reducer of ferredoxin and the electron acceptor of plastocyanin. We isolated the complex fr...

journal_title：PLoS biology

authors： Kiley P,Zhao X,Vaughn M,Baldo MA,Bruce BD,Zhang S

更新日期：2005-07-01 00:00:00

abstract：:Changing environmental conditions cause changes in the distributions of phenotypic traits in natural populations. However, determining the mechanisms responsible for these changes-and, in particular, the relative contributions of phenotypic plasticity versus evolutionary responses-is difficult. To our knowledge, no st...

journal_title：PLoS biology

authors： Bonnet T,Morrissey MB,Morris A,Morris S,Clutton-Brock TH,Pemberton JM,Kruuk LEB

更新日期：2019-11-05 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats. Here, we report that Drosophila larvae exhibit a novel appetitive feeding behavio...

journal_title：PLoS biology

authors： Mishra D,Thorne N,Miyamoto C,Jagge C,Amrein H

更新日期：2018-08-07 00:00:00

abstract：:The human body is a complex organism, the gross mechanical properties of which are enabled by an interconnected musculoskeletal network controlled by the nervous system. The nature of musculoskeletal interconnection facilitates stability, voluntary movement, and robustness to injury. However, a fundamental understandi...

journal_title：PLoS biology

authors： Murphy AC,Muldoon SF,Baker D,Lastowka A,Bennett B,Yang M,Bassett DS

更新日期：2018-01-18 00:00:00

abstract：:The source of symmetry breaking in vertebrate oocytes is unknown. Animal-vegetal oocyte polarity is established by the Balbiani body (Bb), a conserved structure found in all animals examined that contains an aggregate of specific mRNAs, proteins, and organelles. The Bb specifies the oocyte vegetal pole, which is key t...

journal_title：PLoS biology

authors： Elkouby YM,Jamieson-Lucy A,Mullins MC

更新日期：2016-01-07 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...

journal_title：PLoS biology

authors： Ricard N,Simons M

更新日期：2015-05-15 00:00:00

abstract：:Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in ...

journal_title：PLoS biology

authors： Lieberman RL

更新日期：2019-04-22 00:00:00

abstract：:The Amazon is Brazil's greatest natural resource and invaluable to the rest of the world as a buffer against climate change. The recent election of Brazil's president brought disputes over development plans for the region back into the spotlight. Historically, the development model for the Amazon has focused on exploi...

journal_title：PLoS biology

authors： Castro MC,Baeza A,Codeço CT,Cucunubá ZM,Dal'Asta AP,De Leo GA,Dobson AP,Carrasco-Escobar G,Lana RM,Lowe R,Monteiro AMV,Pascual M,Santos-Vega M

更新日期：2019-11-15 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1001326.]. ...

journal_title：PLoS biology

authors： Lu W,Hu Y,Chen G,Chen Z,Zhang H,Wang F,Feng L,Pelicano H,Wang H,Keating MJ,Liu J,McKeehan W,Wang H,Luo Y,Huang P

更新日期：2017-12-11 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.1002454.]. ...

journal_title：PLoS biology

authors： Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

更新日期：2018-03-14 00:00:00

abstract：:The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...

journal_title：PLoS biology

authors： El-Athman R,Genov NN,Mazuch J,Zhang K,Yu Y,Fuhr L,Abreu M,Li Y,Wallach T,Kramer A,Schmitt CA,Relógio A

更新日期：2017-12-07 00:00:00

abstract：:The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central to innate immunity. Drosophila has emerged as an invaluable model org...

journal_title：PLoS biology

authors： Foley E,O'Farrell PH

更新日期：2004-08-01 00:00:00

abstract：:Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...

journal_title：PLoS biology

authors： Yenni GM,Christensen EM,Bledsoe EK,Supp SR,Diaz RM,White EP,Ernest SKM

更新日期：2019-01-29 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00