When it is better to regress: dynamics of vascular pruning.

Abstract:

:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.

journal_name

PLoS Biol

journal_title

PLoS biology

authors

Ricard N,Simons M

doi

10.1371/journal.pbio.1002148

subject

Has Abstract

pub_date

2015-05-15 00:00:00

pages

e1002148

issue

5

eissn

1544-9173

issn

1545-7885

pii

PBIOLOGY-D-15-00651

journal_volume

13

pub_type

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