Abstract:
:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and organ-specific differentiation. However, an equally essential step in this process is the pruning of excessive blood vessels. Recent studies have shown that pruning is critical for the effective perfusion of blood into tissues. Despite its significance, vessel pruning is the least understood process in vascular differentiation and development. Two recently published PLOS Biology papers provide important new information about cellular dynamics of vascular regression.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Ricard N,Simons Mdoi
10.1371/journal.pbio.1002148subject
Has Abstractpub_date
2015-05-15 00:00:00pages
e1002148issue
5eissn
1544-9173issn
1545-7885pii
PBIOLOGY-D-15-00651journal_volume
13pub_type
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