Functional dissection of the proton pumping modules of mitochondrial complex I.

abstract：:Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approxi...

journal_title：PLoS biology

authors： Freedman LP,Cockburn IM,Simcoe TS

更新日期：2015-06-09 00:00:00

abstract：:The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory epithelia, which is attributed to the degradation of the misfolded chan...

journal_title：PLoS biology

authors： Veit G,Oliver K,Apaja PM,Perdomo D,Bidaud-Meynard A,Lin ST,Guo J,Icyuz M,Sorscher EJ,Hartman JL IV,Lukacs GL

更新日期：2016-05-11 00:00:00

abstract：:Temporarily holding information in mind is an important part of many cognitive processes, such as reasoning and language. The amount of information that can be actively held "in mind" at any time is greatly limited-research suggests that we can only actively hold three or four pieces of information at once. A central ...

journal_title：PLoS biology

authors： Hakim N,Vogel EK

更新日期：2018-08-29 00:00:00

abstract：:Mutations affect individual health, population persistence, adaptation, diversification, and genome evolution. There is evidence that the mutation rate varies among genotypes, but the causes of this variation are poorly understood. Here, we link differences in genetic quality with variation in spontaneous mutation in ...

journal_title：PLoS biology

authors： Sharp NP,Agrawal AF

更新日期：2016-03-25 00:00:00

abstract：:Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a method that exploits ...

journal_title：PLoS biology

authors： Kallimasioti-Pazi EM,Thelakkad Chathoth K,Taylor GC,Meynert A,Ballinger T,Kelder MJE,Lalevée S,Sanli I,Feil R,Wood AJ

更新日期：2018-12-12 00:00:00

abstract：:Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown. We found that adipocytes require Cu to establish a balance between main metabolic fuels. Differentiating adipocytes increase their Cu uptake along with the ATP7...

journal_title：PLoS biology

authors： Yang H,Ralle M,Wolfgang MJ,Dhawan N,Burkhead JL,Rodriguez S,Kaplan JH,Wong GW,Haughey N,Lutsenko S

更新日期：2018-09-10 00:00:00

abstract：:We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis...

journal_title：PLoS biology

authors： Blatti C 3rd,Emad A,Berry MJ,Gatzke L,Epstein M,Lanier D,Rizal P,Ge J,Liao X,Sobh O,Lambert M,Post CS,Xiao J,Groves P,Epstein AT,Chen X,Srinivasan S,Lehnert E,Kalari KR,Wang L,Weinshilboum RM,Song JS,Jongeneel

更新日期：2020-01-23 00:00:00

abstract：:Pheromones form an essential chemical language of intraspecific communication in many animals. How olfactory systems recognize pheromonal signals with both sensitivity and specificity is not well understood. An important in vivo paradigm for this process is the detection mechanism of the sex pheromone (Z)-11-octadecen...

journal_title：PLoS biology

authors： Gomez-Diaz C,Reina JH,Cambillau C,Benton R

更新日期：2013-01-01 00:00:00

abstract：:The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a plateau. Using experimental evolution with bacteriophage, we show here that the converse is also true. In populations small e...

journal_title：PLoS biology

authors： Silander OK,Tenaillon O,Chao L

更新日期：2007-04-01 00:00:00

abstract：:Recent findings suggest that functional brain imaging might be used to identify consciousness in patients diagnosed with persistent vegetative state and minimally conscious state. Michael Rafii and James Brewer discuss the potential for fMRI's wider implementation in clinical practice, and associated caveats. ...

journal_title：PLoS biology

authors： Rafii MS,Brewer JB

更新日期：2010-11-30 00:00:00

abstract：:The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP hydrolysis. When filaments form on duplex DNA, RecA protein exhibits a fu...

journal_title：PLoS biology

authors： Cox JM,Tsodikov OV,Cox MM

更新日期：2005-02-01 00:00:00

abstract：:The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis. Whereas bacterial conjugation spreads antibiotic resistance, Agrobacterium facilitates efficient interkingdom transfer of ssDNA from...

journal_title：PLoS biology

authors： Grange W,Duckely M,Husale S,Jacob S,Engel A,Hegner M

更新日期：2008-02-01 00:00:00

abstract：:The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a phase of massive growth and concomitant patterning during larval s...

journal_title：PLoS biology

authors： Hamaratoglu F,de Lachapelle AM,Pyrowolakis G,Bergmann S,Affolter M

更新日期：2011-10-01 00:00:00

abstract：:Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...

journal_title：PLoS biology

authors： Breckenridge RA,Piotrowska I,Ng KE,Ragan TJ,West JA,Kotecha S,Towers N,Bennett M,Kienesberger PC,Smolenski RT,Siddall HK,Offer JL,Mocanu MM,Yelon DM,Dyck JR,Griffin JL,Abramov AY,Gould AP,Mohun TJ

更新日期：2013-09-01 00:00:00

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

journal_title：PLoS biology

authors： Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

更新日期：2021-01-04 00:00:00

abstract：:Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...

journal_title：PLoS biology

authors： Korkaya H,Paulson A,Charafe-Jauffret E,Ginestier C,Brown M,Dutcher J,Clouthier SG,Wicha MS

更新日期：2009-06-02 00:00:00

abstract：:Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic...

journal_title：PLoS biology

authors： Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK

更新日期：2009-11-01 00:00:00

abstract：:Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

journal_title：PLoS biology

authors： Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

更新日期：2017-06-26 00:00:00

abstract：:The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparative analysis of XPD f...

journal_title：PLoS biology

authors： Kuper J,Braun C,Elias A,Michels G,Sauer F,Schmitt DR,Poterszman A,Egly JM,Kisker C

更新日期：2014-09-30 00:00:00

abstract：:Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begi...

journal_title：PLoS biology

authors： Chevin LM,Lande R,Mace GM

更新日期：2010-04-27 00:00:00

abstract：:During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome-encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells. Thus-in the context of agonist treatment during IVF-these r...

journal_title：PLoS biology

authors： Navarro-Costa PA,Molaro A,Misra CS,Meiklejohn CD,Ellis PJ

更新日期：2020-03-23 00:00:00

abstract：:Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the ...

journal_title：PLoS biology

authors： Bermúdez-López M,Pociño-Merino I,Sánchez H,Bueno A,Guasch C,Almedawar S,Bru-Virgili S,Garí E,Wyman C,Reverter D,Colomina N,Torres-Rosell J

更新日期：2015-03-12 00:00:00

abstract：:Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...

journal_title：PLoS biology

authors： Gretenkord S,Kostka JK,Hartung H,Watznauer K,Fleck D,Minier-Toribio A,Spehr M,Hanganu-Opatz IL

更新日期：2019-01-31 00:00:00

abstract：:Cobalamin-independent methionine synthase (MetE) catalyzes the transfer of a methyl group from methyltetrahydrofolate to L-homocysteine (Hcy) without using an intermediate methyl carrier. Although MetE displays no detectable sequence homology with cobalamin-dependent methionine synthase (MetH), both enzymes require zi...

journal_title：PLoS biology

authors： Pejchal R,Ludwig ML

更新日期：2005-02-01 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phen...

journal_title：PLoS biology

authors： Leone TC,Lehman JJ,Finck BN,Schaeffer PJ,Wende AR,Boudina S,Courtois M,Wozniak DF,Sambandam N,Bernal-Mizrachi C,Chen Z,Holloszy JO,Medeiros DM,Schmidt RE,Saffitz JE,Abel ED,Semenkovich CF,Kelly DP

更新日期：2005-04-01 00:00:00

abstract：:Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of cancer-related inflammation. Although the widely used treatment for prostate cance...

journal_title：PLoS biology

authors： Bousset L,Septier A,Bunay J,Voisin A,Guiton R,Damon-Soubeyrant C,Renaud Y,De Haze A,Sapin V,Fogli A,Rambur A,De Joussineau C,Kocer A,Trousson A,Henry-Berger J,Höring M,Liebisch G,Matysik S,Lobaccaro JA,Morel L,Bar

更新日期：2020-12-07 00:00:00

abstract：:Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GPCRs) in this dynamic germline regulation. By genome-enabled receptor ...

journal_title：PLoS biology

authors： Saberi A,Jamal A,Beets I,Schoofs L,Newmark PA

更新日期：2016-05-10 00:00:00

abstract：:Adult humans possess a sophisticated repertoire of mathematical faculties. Many of these capacities are rooted in symbolic language and are therefore unlikely to be shared with nonhuman animals. However, a subset of these skills is shared with other animals, and this set is considered a cognitive vestige of our common...

journal_title：PLoS biology

authors： Cantlon JF,Brannon EM

更新日期：2007-12-01 00:00:00