Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History.

abstract：:The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neur...

journal_title：PLoS biology

authors： Courellis HS,Nummela SU,Metke M,Diehl GW,Bussell R,Cauwenberghs G,Miller CT

更新日期：2019-12-09 00:00:00

abstract：:The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...

journal_title：PLoS biology

authors： Ma S,Kwon HJ,Johng H,Zang K,Huang Z

更新日期：2013-01-01 00:00:00

abstract：:Both endocrine and exocrine pancreatic cells arise from pancreatic-duodenal homeobox 1 (pdx1)-positive progenitors. The molecular mechanisms controlling cell fate determination and subsequent proliferation, however, are poorly understood. Unlike endocrine cells, less is known about exocrine cell specification. We repo...

journal_title：PLoS biology

authors： Jiang Z,Song J,Qi F,Xiao A,An X,Liu NA,Zhu Z,Zhang B,Lin S

更新日期：2008-11-25 00:00:00

abstract：:Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. C...

journal_title：PLoS biology

authors： Capes-Davis A,Neve RM

更新日期：2016-06-14 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...

journal_title：PLoS biology

authors： Sriram K,Moyung K,Corriden R,Carter H,Insel PA

更新日期：2019-11-25 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation,...

journal_title：PLoS biology

authors： Gallego del Sol F,Marina A

更新日期：2013-01-01 00:00:00

abstract：:The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this couple...

journal_title：PLoS biology

authors： El-Athman R,Genov NN,Mazuch J,Zhang K,Yu Y,Fuhr L,Abreu M,Li Y,Wallach T,Kramer A,Schmitt CA,Relógio A

更新日期：2017-12-07 00:00:00

abstract：:Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized pr...

journal_title：PLoS biology

authors： Willemen HLDM,Kavelaars A,Prado J,Maas M,Versteeg S,Nellissen LJJ,Tromp J,Gonzalez Cano R,Zhou W,Jakobsson ME,Małecki J,Posthuma G,Habib AM,Heijnen CJ,Falnes PØ,Eijkelkamp N

更新日期：2018-02-14 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...

journal_title：PLoS biology

authors： Hoehl S,Markova G

更新日期：2018-12-13 00:00:00

abstract：:Cell proliferation and programmed cell death are closely controlled during animal development. Proliferative stimuli generally also induce apoptosis, and anti-apoptotic factors are required to allow net cell proliferation. Genetic studies in Drosophila have led to identification of a number of genes that control both ...

journal_title：PLoS biology

authors： Hipfner DR,Cohen SM

更新日期：2003-11-01 00:00:00

abstract：:Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer's disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familial AD (5×FAD) mice, ...

journal_title：PLoS biology

authors： Xu J,Yu T,Pietronigro EC,Yuan J,Arioli J,Pei Y,Luo X,Ye J,Constantin G,Mao C,Xiao Y

更新日期：2020-10-05 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...

journal_title：PLoS biology

authors： Barbeito-Andrés J,Schuler-Faccini L,Garcez PP

更新日期：2018-08-24 00:00:00

abstract：:Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated a frontal-parietal network in the top-down control of attention. However, little is known about the timing and sequence of activations within this network. To investigate these timing questions, we used event-related electr...

journal_title：PLoS biology

authors： Grent-'t-Jong T,Woldorff MG

更新日期：2007-01-01 00:00:00

abstract：:Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...

journal_title：PLoS biology

authors： Pascucci D,Mancuso G,Santandrea E,Della Libera C,Plomp G,Chelazzi L

更新日期：2019-03-05 00:00:00

abstract：:A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...

journal_title：PLoS biology

authors： Reindl KM,White AR,Johnson C,Vender B,Slator BM,McClean P

更新日期：2015-04-09 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalam...

journal_title：PLoS biology

authors： Zhang H,Zhang G,Gonzalez FJ,Park SM,Cai D

更新日期：2011-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000193.]. ...

journal_title：PLoS biology

authors： Field KA,Paquet PC,Artelle K,Proulx G,Brook RK,Darimont CT

更新日期：2020-05-18 00:00:00

abstract：:Birds utilize a unique structure, called a syrinx, for the production of their vocalizations. The origins of the syrinx are not well understood. New work, utilizing first principles-based models, suggests that a key element in selection for the early syrinx might be the position of this vocal structure: although the l...

journal_title：PLoS biology

authors： Habib MB

更新日期：2019-03-28 00:00:00

abstract：:Recently, prominent theoretical linguists have argued for an explicit scenario for the evolution of the human language capacity on the basis of its computational properties. Concretely, the simplicity of a minimalist formulation of the operation Merge, which allows humans to recursively compute hierarchical relations ...

journal_title：PLoS biology

authors： Martins PT,Boeckx C

更新日期：2019-11-27 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000311.]. ...

journal_title：PLoS biology

authors： Simeon R,Jiang M,Chamoun-Emanuelli AM,Yu H,Zhang Y,Meng R,Peng Z,Jakana J,Zhang J,Feng H,Chen Z

更新日期：2019-10-04 00:00:00

abstract：:Rapidly grouping local elements into an organized object (i.e., perceptual integration) is a fundamental yet challenging task, especially in noisy contexts. Previous studies demonstrate that ventral visual pathway, which is widely known to mediate object recognition, engages in the process by conveying object-level in...

journal_title：PLoS biology

authors： Liu L,Wang F,Zhou K,Ding N,Luo H

更新日期：2017-11-30 00:00:00

abstract：:There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo. Here, by using the multi-protein tip complex of the mannose-binding type 1 fimb...

journal_title：PLoS biology

authors： Aprikian P,Interlandi G,Kidd BA,Le Trong I,Tchesnokova V,Yakovenko O,Whitfield MJ,Bullitt E,Stenkamp RE,Thomas WE,Sokurenko EV

更新日期：2011-05-01 00:00:00

abstract：:Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse model of pancreatic islet cell tumorigenesis can be used to meas...

journal_title：PLoS biology

authors： Du YC,Lewis BC,Hanahan D,Varmus H

更新日期：2007-10-16 00:00:00

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few h...

journal_title：PLoS biology

authors： Herzig Y,Sharpe HJ,Elbaz Y,Munro S,Schuldiner M

更新日期：2012-01-01 00:00:00

abstract：:A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly ...

journal_title：PLoS biology

authors： Shirangi TR,Dufour HD,Williams TM,Carroll SB

更新日期：2009-08-01 00:00:00