Abstract:
:Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized protein. We demonstrate here that FAM173B is a mitochondrial lysine methyltransferase that promotes chronic pain. Knockdown and sensory neuron overexpression strategies showed that FAM173B is involved in persistent inflammatory and neuropathic pain via a pathway dependent on its methyltransferase activity. FAM173B methyltransferase activity in sensory neurons hyperpolarized mitochondria and promoted macrophage/microglia activation through a reactive oxygen species-dependent pathway. In summary, we uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions.
journal_name
PLoS Bioljournal_title
PLoS biologyauthors
Willemen HLDM,Kavelaars A,Prado J,Maas M,Versteeg S,Nellissen LJJ,Tromp J,Gonzalez Cano R,Zhou W,Jakobsson ME,Małecki J,Posthuma G,Habib AM,Heijnen CJ,Falnes PØ,Eijkelkamp Ndoi
10.1371/journal.pbio.2003452subject
Has Abstractpub_date
2018-02-14 00:00:00pages
e2003452issue
2eissn
1544-9173issn
1545-7885pii
pbio.2003452journal_volume
16pub_type
杂志文章相关文献
PLOS BIOLOGY文献大全abstract::It has been reported that feeding mice resveratrol activates AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1α, increased mitochondrial biogenesis, and improved running endurance. This study was done to further evaluate the effects of resveratrol, SIRT1, and PGC-1α deacetylation on mi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001603
更新日期:2013-07-01 00:00:00
abstract::Over the last decades, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and behavior. This arduous work has yielded results with far-reaching consequences in metabolic, psychiatric, and neoplastic disorders. Recent attempts to expand our understanding of circadian regulation...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001840
更新日期:2014-04-15 00:00:00
abstract::The small GTPase Rab5 is a key regulator of clathrin-mediated endocytosis. On early endosomes, within a spatially restricted domain enriched in phosphatydilinositol-3-phosphate [PI(3)P], Rab5 coordinates a complex network of effectors that functionally cooperate in membrane tethering, fusion, and organelle motility. H...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020261
更新日期:2004-09-01 00:00:00
abstract:UNLABELLED:Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being reward...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000164
更新日期:2009-07-01 00:00:00
abstract::We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000583
更新日期:2020-01-23 00:00:00
abstract::A recent report by the Institute of Medicine leaves few urgent reasons standing for the continued use of chimpanzees in biomedical research. It is high time to think about their retirement, Frans de Waal argues, without neglecting prospects for non-invasive research on behavior, cognition, and genetics. ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001291
更新日期:2012-01-01 00:00:00
abstract::Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000139
更新日期:2019-02-04 00:00:00
abstract::A lysosomal storage disease (LSD) results from deficient lysosomal enzyme activity, thus the substrate of the mutant enzyme accumulates in the lysosome, leading to pathology. In many but not all LSDs, the clinically most important mutations compromise the cellular folding of the enzyme, subjecting it to endoplasmic re...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060026
更新日期:2008-02-01 00:00:00
abstract::Almost all higher organisms, including plants, insects, and mammals, are colonized by complex microbial communities and harbor a microbiome. Emerging studies with plants reveal that these microbiomes are structured and form complex, interconnected microbial networks. Within these networks, different taxa have differen...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.1002378
更新日期:2016-02-12 00:00:00
abstract::Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001926
更新日期:2014-08-12 00:00:00
abstract::Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003355
更新日期:2017-11-28 00:00:00
abstract::Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000237
更新日期:2019-04-22 00:00:00
abstract::The cerebellum has been proposed to be a crucial component in the state estimation process that combines information from motor efferent and sensory afferent signals to produce a representation of the current state of the motor system. Such a state estimate of the moving human arm would be expected to be used when the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050316
更新日期:2007-11-01 00:00:00
abstract::Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0020207
更新日期:2004-07-01 00:00:00
abstract::Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces cerevisiae (budding yeast) and elsewhere. To provide more perspective on these regulatory mec...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0030225
更新日期:2005-07-01 00:00:00
abstract::A cell is a minifactory in which structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transported. Because cellular structures and molecules are invisible to the human eye, students often have difficulty conceptualizing the dynamic nature of cells that function at multiple scales acr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002118
更新日期:2015-04-09 00:00:00
abstract::The molecular mechanisms by which floral homeotic genes act as major developmental switches to specify the identity of floral organs are still largely unknown. Floral homeotic genes encode transcription factors of the MADS-box family, which are supposed to assemble in a combinatorial fashion into organ-specific multim...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000090
更新日期:2009-04-21 00:00:00
abstract::Although psychological and computational models of time estimation have postulated the existence of neural representations tuned for specific durations, empirical evidence of this notion has been lacking. Here, using a functional magnetic resonance imaging (fMRI) adaptation paradigm, we show that the inferior parietal...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1002262
更新日期:2015-09-17 00:00:00
abstract::Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040322
更新日期:2006-10-01 00:00:00
abstract::In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantage. The resulting frequency-dependent selection can structure parasite populations into strains of limited genetic overlap. For the causative agent of malaria, Plasmodium falciparum, the hig...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000336
更新日期:2019-06-24 00:00:00
abstract::Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002711
更新日期:2017-06-26 00:00:00
abstract::The Amazon is Brazil's greatest natural resource and invaluable to the rest of the world as a buffer against climate change. The recent election of Brazil's president brought disputes over development plans for the region back into the spotlight. Historically, the development model for the Amazon has focused on exploi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000526
更新日期:2019-11-15 00:00:00
abstract::Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic treatment remains u...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002810
更新日期:2017-11-06 00:00:00
abstract::Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000121
更新日期:2009-06-02 00:00:00
abstract::In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001021
更新日期:2011-03-01 00:00:00
abstract::Although amyloid fibrillation is generally believed to be a nucleation-dependent process, the nuclei are largely structurally uncharacterized. This is in part due to the inherent experimental challenge associated with structural descriptions of individual components in a dynamic multi-component equilibrium. There are ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0050134
更新日期:2007-05-01 00:00:00
abstract::Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0040417
更新日期:2006-12-01 00:00:00
abstract::Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide (HX). This paradigm is at the basis of the vast majority of expe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1001351
更新日期:2012-01-01 00:00:00
abstract::Many species are experiencing sustained environmental change mainly due to human activities. The unusual rate and extent of anthropogenic alterations of the environment may exceed the capacity of developmental, genetic, and demographic mechanisms that populations have evolved to deal with environmental change. To begi...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.1000357
更新日期:2010-04-27 00:00:00
abstract::In Amazonian tropical forests, recent studies have reported increases in aboveground biomass and in primary productivity, as well as shifts in plant species composition favouring fast-growing species over slow-growing ones. This pervasive alteration of mature tropical forests was attributed to global environmental cha...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.0060045
更新日期:2008-03-04 00:00:00