Genes, cells, and biobanks: Yes, there's still a consent problem.

abstract：:Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated wit...

journal_title：PLoS biology

authors： Kaeberlein M,Kirkland KT,Fields S,Kennedy BK

更新日期：2004-09-01 00:00:00

abstract：:In mammalian oocytes, three actin binding proteins, Formin 2 (Fmn2), Spire, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization. Here we characterize Fmn2 and elucidate the molecular mechan...

journal_title：PLoS biology

authors： Montaville P,Jégou A,Pernier J,Compper C,Guichard B,Mogessie B,Schuh M,Romet-Lemonne G,Carlier MF

更新日期：2014-02-25 00:00:00

abstract：:The ability to identify and react to novelty within the environment is fundamental to survival. Computational models emphasize the potential role of the hippocampus in novelty detection, its unique anatomical circuitry making it ideally suited to act as a comparator between past and present experience. The hippocampus...

journal_title：PLoS biology

authors： Kumaran D,Maguire EA

更新日期：2006-11-01 00:00:00

abstract：:We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system for analysis of genomics data sets, designed to accelerate biomedical discovery. It includes tools for popular bioinformatics tasks such as gene prioritization, sample clustering, gene set analysis, and expression signature analysis...

journal_title：PLoS biology

authors： Blatti C 3rd,Emad A,Berry MJ,Gatzke L,Epstein M,Lanier D,Rizal P,Ge J,Liao X,Sobh O,Lambert M,Post CS,Xiao J,Groves P,Epstein AT,Chen X,Srinivasan S,Lehnert E,Kalari KR,Wang L,Weinshilboum RM,Song JS,Jongeneel

更新日期：2020-01-23 00:00:00

abstract：:The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice. PGC-1alpha null (PGC-1alpha(-/-)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phen...

journal_title：PLoS biology

authors： Leone TC,Lehman JJ,Finck BN,Schaeffer PJ,Wende AR,Boudina S,Courtois M,Wozniak DF,Sambandam N,Bernal-Mizrachi C,Chen Z,Holloszy JO,Medeiros DM,Schmidt RE,Saffitz JE,Abel ED,Semenkovich CF,Kelly DP

更新日期：2005-04-01 00:00:00

abstract：:Over the last decades, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and behavior. This arduous work has yielded results with far-reaching consequences in metabolic, psychiatric, and neoplastic disorders. Recent attempts to expand our understanding of circadian regulation...

journal_title：PLoS biology

authors： Anafi RC,Lee Y,Sato TK,Venkataraman A,Ramanathan C,Kavakli IH,Hughes ME,Baggs JE,Growe J,Liu AC,Kim J,Hogenesch JB

更新日期：2014-04-15 00:00:00

abstract：:Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions withi...

journal_title：PLoS biology

authors： Bell CH,Porter SL,Strawson A,Stuart DI,Armitage JP

更新日期：2010-02-09 00:00:00

abstract：:Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptos...

journal_title：PLoS biology

authors： Zargarian S,Shlomovitz I,Erlich Z,Hourizadeh A,Ofir-Birin Y,Croker BA,Regev-Rudzki N,Edry-Botzer L,Gerlic M

更新日期：2017-06-26 00:00:00

abstract：:Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell ...

journal_title：PLoS biology

authors： Hatzold J,Conradt B

更新日期：2008-04-08 00:00:00

abstract：:The cerebral cortex performs complex cognitive functions at the expense of tremendous energy consumption. Blood vessels in the brain are known to form stereotypic patterns that facilitate efficient oxygen and nutrient delivery. Yet little is known about how vessel development in the brain is normally regulated. Radial...

journal_title：PLoS biology

authors： Ma S,Kwon HJ,Johng H,Zang K,Huang Z

更新日期：2013-01-01 00:00:00

abstract：:Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, i...

journal_title：PLoS biology

authors： Lozoya OA,Martinez-Reyes I,Wang T,Grenet D,Bushel P,Li J,Chandel N,Woychik RP,Santos JH

更新日期：2018-04-18 00:00:00

abstract：:Genome-wide studies of circadian transcription or mRNA translation have been hindered by the presence of heterogeneous cell populations in complex tissues such as the nervous system. We describe here the use of a Drosophila cell-specific translational profiling approach to document the rhythmic "translatome" of neural...

journal_title：PLoS biology

authors： Huang Y,Ainsley JA,Reijmers LG,Jackson FR

更新日期：2013-11-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.3000478.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2019-11-13 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster,...

journal_title：PLoS biology

authors： Leitão-Gonçalves R,Carvalho-Santos Z,Francisco AP,Fioreze GT,Anjos M,Baltazar C,Elias AP,Itskov PM,Piper MDW,Ribeiro C

更新日期：2017-04-25 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Here, we have used a graph theory-based systems biology approach to dete...

journal_title：PLoS biology

authors： Novkovic M,Onder L,Cupovic J,Abe J,Bomze D,Cremasco V,Scandella E,Stein JV,Bocharov G,Turley SJ,Ludewig B

更新日期：2016-07-14 00:00:00

abstract：:The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, ...

journal_title：PLoS biology

authors： de Sousa N,Rodríguez-Esteban G,Rojo-Laguna JI,Saló E,Adell T

更新日期：2018-01-22 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown. ...

journal_title：PLoS biology

authors： Stoeger T,Gerlach M,Morimoto RI,Amaral LAN

更新日期：2018-12-11 00:00:00

abstract：:Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...

journal_title：PLoS biology

authors： Gretenkord S,Kostka JK,Hartung H,Watznauer K,Fleck D,Minier-Toribio A,Spehr M,Hanganu-Opatz IL

更新日期：2019-01-31 00:00:00

abstract：:Modern whole-organism genome analysis, in combination with biomass estimates, allows us to estimate a lower bound on the total information content in the biosphere: 5.3 × 1031 (±3.6 × 1031) megabases (Mb) of DNA. Given conservative estimates regarding DNA transcription rates, this information content suggests biospher...

journal_title：PLoS biology

authors： Landenmark HK,Forgan DH,Cockell CS

更新日期：2015-06-11 00:00:00

abstract：:Pathogenicity of Pseudomonas syringae is dependent on a type III secretion system, which secretes a suite of virulence effector proteins into the host cytoplasm, and the production of a number of toxins such as coronatine (COR), which is a mimic of the plant hormone jasmonate-isoleuce (JA-Ile). Inside the plant cell, ...

journal_title：PLoS biology

authors： Gimenez-Ibanez S,Boter M,Fernández-Barbero G,Chini A,Rathjen JP,Solano R

更新日期：2014-02-18 00:00:00

abstract：:Tools enabling closed-loop experiments are crucial to delineate causal relationships between the activity of genetically labeled neurons and specific behaviors. We developed the Raspberry Pi Virtual Reality (PiVR) system to conduct closed-loop optogenetic stimulation of neural functions in unrestrained animals. PiVR i...

journal_title：PLoS biology

authors： Tadres D,Louis M

更新日期：2020-07-14 00:00:00

abstract：:With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena. The genetics of transcriptional regulation and protein abundance are likely to be complex, meaning that genetic variation at multiple loci will infl...

journal_title：PLoS biology

authors： Storey JD,Akey JM,Kruglyak L

更新日期：2005-08-01 00:00:00

abstract：:Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...

journal_title：PLoS biology

authors： Zhang X,Alexander N,Leonardi I,Mason C,Kirkman LA,Deitsch KW

更新日期：2019-05-13 00:00:00

abstract：:Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...

journal_title：PLoS biology

authors： Breckenridge RA,Piotrowska I,Ng KE,Ragan TJ,West JA,Kotecha S,Towers N,Bennett M,Kienesberger PC,Smolenski RT,Siddall HK,Offer JL,Mocanu MM,Yelon DM,Dyck JR,Griffin JL,Abramov AY,Gould AP,Mohun TJ

更新日期：2013-09-01 00:00:00

abstract：:Glial cells surround neuronal endings to create enclosed compartments required for neuronal function. This architecture is seen at excitatory synapses and at sensory neuron receptive endings. Despite the prevalence and importance of these compartments, how they form is not known. We used the main sensory organ of C. e...

journal_title：PLoS biology

authors： Oikonomou G,Perens EA,Lu Y,Watanabe S,Jorgensen EM,Shaham S

更新日期：2011-08-01 00:00:00

abstract：:Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip has been reported in many vertebrates. However, the knowledge about the subcellular dynamics and molecular mechanisms regulating directional neuronal migration in vivo is just beginning to emerge. Here we show by time-lapse ...

journal_title：PLoS biology

authors： Rieger S,Senghaas N,Walch A,Köster RW

更新日期：2009-11-01 00:00:00

abstract：:There is currently a demand for new highly efficient and specific drugs to treat osteoporosis, a chronic bone disease affecting millions of people worldwide. We have developed a combinatorial strategy for engineering bispecific inhibitors that simultaneously target the unique combination of c-FMS and αvβ3 integrin, wh...

journal_title：PLoS biology

authors： Zur Y,Rosenfeld L,Keshelman CA,Dalal N,Guterman-Ram G,Orenbuch A,Einav Y,Levaot N,Papo N

更新日期：2018-08-24 00:00:00

abstract：:The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmental organization of the vertebrate central nervous system. In the hindbrain and spinal cord, distinctions in the rostrocaudal identity of progenitor cells are associated with the generation of ...

journal_title：PLoS biology

authors： Nordström U,Maier E,Jessell TM,Edlund T

更新日期：2006-07-01 00:00:00