Sex and suicide: The curious case of Toll-like receptors.

abstract：:CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases. Molecular analyses have recently detailed the lipid antigen recognition strategies utilized by the invariant Vα24-Jα18 TCR rearrangements of iNKT cells, wh...

journal_title：PLoS biology

authors： López-Sagaseta J,Kung JE,Savage PB,Gumperz J,Adams EJ

更新日期：2012-01-01 00:00:00

abstract：:Instead of combating the acidification of the host cell vacuole, Salmonella acidifies its own cytoplasm in response to the low extracellular pH, helping it to secrete effector molecules. ...

journal_title：PLoS biology

authors： Richardson LA

更新日期：2015-04-14 00:00:00

abstract：:Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...

journal_title：PLoS biology

authors： Maia Chagas A

更新日期：2018-09-27 00:00:00

abstract：:In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secretory proteins, which are targeted to the endoplasmic reticulum membran...

journal_title：PLoS biology

authors： Palazzo AF,Springer M,Shibata Y,Lee CS,Dias AP,Rapoport TA

更新日期：2007-12-01 00:00:00

abstract：:A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems,...

journal_title：PLoS biology

authors： Fox S,Southam P,Pantin F,Kennaway R,Robinson S,Castorina G,Sánchez-Corrales YE,Sablowski R,Chan J,Grieneisen V,Marée AFM,Bangham JA,Coen E

更新日期：2018-11-01 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Membrane bioenergetics are universal, yet the phospholipid membranes of archaea and bacteria-the deepest branches in the tree of life-are fundamentally different. This deep divergence in membrane chemistry is reflected in other stark differences between the two domains, including ion pumping and DNA replication. We re...

journal_title：PLoS biology

authors： Sojo V,Pomiankowski A,Lane N

更新日期：2014-08-12 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analys...

journal_title：PLoS biology

authors： McGrath TM,Spreckley E,Rodriguez AF,Viscomi C,Alamshah A,Akalestou E,Murphy KG,Jones NS

更新日期：2019-12-05 00:00:00

abstract：:Why do we sleep? The sleep patterns and mechanisms that occur throughout development may give us a clue. ...

journal_title：PLoS biology

authors： Siegel JM

更新日期：2005-05-01 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:Over 20 years ago, alterations to the protein myocilin were confirmed to be linked to a heritable form of the prevalent eye disease, glaucoma, and 10 years ago, my lab set out to develop a deeper understanding of myocilin in its normal and diseased state. We have made strides in understanding how genetic mutations in ...

journal_title：PLoS biology

authors： Lieberman RL

更新日期：2019-04-22 00:00:00

abstract：:Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, which shifts from glycolysis to lipid oxidation soon after birth, and i...

journal_title：PLoS biology

authors： Breckenridge RA,Piotrowska I,Ng KE,Ragan TJ,West JA,Kotecha S,Towers N,Bennett M,Kienesberger PC,Smolenski RT,Siddall HK,Offer JL,Mocanu MM,Yelon DM,Dyck JR,Griffin JL,Abramov AY,Gould AP,Mohun TJ

更新日期：2013-09-01 00:00:00

abstract：:Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a microscopy-based genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins required for centriole duplication and mitotic PCM recruitment. We analysed 92% of the Droso...

journal_title：PLoS biology

authors： Dobbelaere J,Josué F,Suijkerbuijk S,Baum B,Tapon N,Raff J

更新日期：2008-09-16 00:00:00

abstract：:The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit ...

journal_title：PLoS biology

authors： Kelsch W,Mosley CP,Lin CW,Lois C

更新日期：2007-11-01 00:00:00

abstract：:In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal and nocturnal species. A recent report by Pilorz and colleagues ...

journal_title：PLoS biology

authors： Bourgin P,Hubbard J

更新日期：2016-08-15 00:00:00

abstract：:RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to th...

journal_title：PLoS biology

authors： Simmer F,Moorman C,van der Linden AM,Kuijk E,van den Berghe PV,Kamath RS,Fraser AG,Ahringer J,Plasterk RH

更新日期：2003-10-01 00:00:00

abstract：:The oversupply of postdoctoral scholars relative to available faculty positions has led to calls for better assessment of career outcomes. Here, we report the results of a study of postdoctoral outcomes at the University of California, San Francisco, and suggest that institutions have an obligation to determine where ...

journal_title：PLoS biology

authors： Silva EA,Des Jarlais C,Lindstaedt B,Rotman E,Watkins ES

更新日期：2016-05-06 00:00:00

abstract：:Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic ...

journal_title：PLoS biology

authors： Cota CD,Dreier MS,Colgan W,Cha A,Sia T,Davidson B

更新日期：2021-01-04 00:00:00

abstract：:Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. Because PTE...

journal_title：PLoS biology

authors： Korkaya H,Paulson A,Charafe-Jauffret E,Ginestier C,Brown M,Dutcher J,Clouthier SG,Wicha MS

更新日期：2009-06-02 00:00:00

abstract：:Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally...

journal_title：PLoS biology

authors： Duveau F,Félix MA

更新日期：2012-01-01 00:00:00

abstract：:African swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat. ASFV DNA Polymerase X (AsfvPolX) is the most distinctive DNA polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologous proteins. AsfvPolX cataly...

journal_title：PLoS biology

authors： Chen Y,Zhang J,Liu H,Gao Y,Li X,Zheng L,Cui R,Yao Q,Rong L,Li J,Huang Z,Ma J,Gan J

更新日期：2017-02-28 00:00:00

abstract：:In an age of free international shipments of mail-ordered seeds and plants, more policing will not stop the global migration of hitchhiking pests. The solution is in a preemptive response based on an internationally coordinated genomic deployment of global biodiversity in the largest breeding project since the "Garden...

journal_title：PLoS biology

authors： Zamir D

更新日期：2016-04-19 00:00:00

abstract：:The developmental transition from a vegetative to a reproductive phase (i.e., flowering) is timed by the seasonal cue day length or photoperiod in many plant species. Through the photoperiod pathway, inductive day lengths trigger the production of a systemic flowering signal, florigen, to provoke the floral transition...

journal_title：PLoS biology

authors： Gu X,Wang Y,He Y

更新日期：2013-09-01 00:00:00

abstract：:Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...

journal_title：PLoS biology

authors： Katsageorgiou VM,Sona D,Zanotto M,Lassi G,Garcia-Garcia C,Tucci V,Murino V

更新日期：2018-05-29 00:00:00

abstract：:Autophagy is the mechanism by which cellular material is delivered to lysosomes and degraded. This process has become a major focus of biological and biomedical research with thousands of papers published each year and rapidly growing appreciation that autophagy affects many normal and pathological processes. However,...

journal_title：PLoS biology

authors： Thorburn A

更新日期：2014-10-14 00:00:00

abstract：:Microsaccades aid vision by helping to strategically sample visual scenes. Despite the importance of these small eye movements, no cortical area has ever been implicated in their generation. Here, we used unilateral and bilateral reversible inactivation of the frontal eye fields (FEF) to identify a cortical drive for ...

journal_title：PLoS biology

authors： Peel TR,Hafed ZM,Dash S,Lomber SG,Corneil BD

更新日期：2016-08-10 00:00:00

abstract：:Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2'-deoxyriboside 5'-triphosphate (5-MeCITP), functions as an inhibitor of telomerase activi...

journal_title：PLoS biology

authors： Hernandez-Sanchez W,Huang W,Plucinsky B,Garcia-Vazquez N,Robinson NJ,Schiemann WP,Berdis AJ,Skordalakes E,Taylor DJ

更新日期：2019-04-05 00:00:00

abstract：:The mechanisms by which genes control organ shape are poorly understood. In principle, genes may control shape by modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because of interactions between patterns, orientations, and mechanical constraints du...

journal_title：PLoS biology

authors： Green AA,Kennaway JR,Hanna AI,Bangham JA,Coen E

更新日期：2010-11-09 00:00:00