Organized unidirectional waves of ATP hydrolysis within a RecA filament.

abstract：:The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb - c > 0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r is their genetic relatedness. While many studies have provided...

journal_title：PLoS biology

authors： Waibel M,Floreano D,Keller L

更新日期：2011-05-01 00:00:00

abstract：:Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibian oocytes, mitotic...

journal_title：PLoS biology

authors： Halley-Stott RP,Jullien J,Pasque V,Gurdon J

更新日期：2014-07-29 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories and 45 subty...

journal_title：PLoS biology

authors： Sriram K,Moyung K,Corriden R,Carter H,Insel PA

更新日期：2019-11-25 00:00:00

abstract：:How should funding agencies enable researchers to explore high-risk but potentially high-reward science? One model that appears to work is the NSF-funded synthesis center, an incubator for community-led, innovative science. ...

journal_title：PLoS biology

authors： Rodrigo A,Alberts S,Cranston K,Kingsolver J,Lapp H,McClain C,Smith R,Vision T,Weintraub J,Wiegmann B

更新日期：2013-01-01 00:00:00

abstract：:Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two closely related Hydra species. We find that species-specific differences i...

journal_title：PLoS biology

authors： Khalturin K,Anton-Erxleben F,Sassmann S,Wittlieb J,Hemmrich G,Bosch TC

更新日期：2008-11-18 00:00:00

abstract：:Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine protein kinases. It is a key regulator downstream of various growth factors and hormones and is involved in malignant transformation and chemo-resistance. Full-length PKB protein has not been crystallised, thus studying the molecular...

journal_title：PLoS biology

authors： Calleja V,Laguerre M,Parker PJ,Larijani B

更新日期：2009-01-20 00:00:00

abstract：:In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...

journal_title：PLoS biology

authors： Bolhuis JJ,Beckers GJL,Huybregts MAC,Berwick RC,Everaert MBH

更新日期：2018-09-24 00:00:00

abstract：:During quiet resting behavior, involuntary movements are suppressed. Such movement control is attributed to cortico-basal ganglia loops, yet population dynamics within these loops during resting and their relation to involuntary movements are not well characterized. Here, we show by recording cortical and striatal ong...

journal_title：PLoS biology

authors： Klaus A,Plenz D

更新日期：2016-12-06 00:00:00

abstract：:A vast and rich body of information has grown up as a result of the world's enthusiasm for 'omics technologies. Finding ways to describe and make available this information that maximise its usefulness has become a major effort across the 'omics world. At the heart of this effort is the Genomic Standards Consortium (G...

journal_title：PLoS biology

authors： Field D,Amaral-Zettler L,Cochrane G,Cole JR,Dawyndt P,Garrity GM,Gilbert J,Glöckner FO,Hirschman L,Karsch-Mizrachi I,Klenk HP,Knight R,Kottmann R,Kyrpides N,Meyer F,San Gil I,Sansone SA,Schriml LM,Sterk P,Tatusova T

更新日期：2011-06-01 00:00:00

abstract：:A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither...

journal_title：PLoS biology

authors： Basile BM,Schafroth JL,Karaskiewicz CL,Chang SWC,Murray EA

更新日期：2020-06-12 00:00:00

abstract：:The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately improved by analytical work, whether ensuring reproducible and well-document...

journal_title：PLoS biology

authors： Kucharski AJ,Funk S,Eggo RM

更新日期：2020-10-16 00:00:00

abstract：:The MooSciTIC project is a capacity-building initiative targeting West African research scientists and higher education teachers. The project aimed to improve the self-reliance of researchers and upgrade research practices by providing on-site summer schools on trans-disciplinary topics such as scientific writing, com...

journal_title：PLoS biology

authors： Atindehou M,Adéoti K,Loko LEY,Beulé T,Paradis E,Djedatin G,Tranchant-Dubreuil C,Sabot F,Lagnika L,Jaligot E

更新日期：2019-06-07 00:00:00

abstract：:Morphological development of fungi and their combined production of secondary metabolites are both acting in defence and protection. These processes are mainly coordinated by velvet regulators, which contain a yet functionally and structurally uncharacterized velvet domain. Here we demonstrate that the velvet domain o...

journal_title：PLoS biology

authors： Ahmed YL,Gerke J,Park HS,Bayram Ö,Neumann P,Ni M,Dickmanns A,Kim SC,Yu JH,Braus GH,Ficner R

更新日期：2013-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pbio.2004814.]. ...

journal_title：PLoS biology

authors： PLOS Biology Staff.

更新日期：2018-01-25 00:00:00

abstract：:The ability to identify and react to novelty within the environment is fundamental to survival. Computational models emphasize the potential role of the hippocampus in novelty detection, its unique anatomical circuitry making it ideally suited to act as a comparator between past and present experience. The hippocampus...

journal_title：PLoS biology

authors： Kumaran D,Maguire EA

更新日期：2006-11-01 00:00:00

abstract：:In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally conserved r...

journal_title：PLoS biology

authors： Sardana R,Liu X,Granneman S,Zhu J,Gill M,Papoulas O,Marcotte EM,Tollervey D,Correll CC,Johnson AW

更新日期：2015-02-24 00:00:00

abstract：:Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial. Much recent research has emphasised the adaptive benefit of acquiring novel DNA, but here we argue instead that intragenomic conflict provides a coherent framewo...

journal_title：PLoS biology

authors： Croucher NJ,Mostowy R,Wymant C,Turner P,Bentley SD,Fraser C

更新日期：2016-03-02 00:00:00

abstract：:Hox transcription factors control a number of developmental processes with the help of the PBC class proteins. In vitro analyses have established that the formation of Hox/PBC complexes relies on a short conserved Hox protein motif called the hexapeptide (HX). This paradigm is at the basis of the vast majority of expe...

journal_title：PLoS biology

authors： Hudry B,Remacle S,Delfini MC,Rezsohazy R,Graba Y,Merabet S

更新日期：2012-01-01 00:00:00

abstract：:The issue of nonreplicable evidence has attracted considerable attention across biomedical and other sciences. This concern is accompanied by an increasing interest in reforming research incentives and practices. How to optimally perform these reforms is a scientific problem in itself, and economics has several scient...

journal_title：PLoS biology

authors： Gall T,Ioannidis JPA,Maniadis Z

更新日期：2017-04-26 00:00:00

abstract：:The ability of cells to accurately control gene expression levels in response to extracellular cues is limited by the inherently stochastic nature of transcriptional regulation. A change in transcription factor (TF) activity results in changes in the expression of its targets, but the way in which cell-to-cell variabi...

journal_title：PLoS biology

authors： Carey LB,van Dijk D,Sloot PM,Kaandorp JA,Segal E

更新日期：2013-01-01 00:00:00

abstract：:The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron microscopy revealed that developing pontine mossy fibers elabora...

journal_title：PLoS biology

authors： Kalinovsky A,Boukhtouche F,Blazeski R,Bornmann C,Suzuki N,Mason CA,Scheiffele P

更新日期：2011-02-08 00:00:00

abstract：:Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are un...

journal_title：PLoS biology

authors： Serrano MLA,Demarest BL,Tone-Pah-Hote T,Tristani-Firouzi M,Yost HJ

更新日期：2019-09-03 00:00:00

abstract：:Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have und...

journal_title：PLoS biology

authors： Rea SL,Ventura N,Johnson TE

更新日期：2007-10-02 00:00:00

abstract：:Active sensing involves the fusion of internally generated motor events with external sensation. For rodents, active somatosensation includes scanning the immediate environment with the mystacial vibrissae. In doing so, the vibrissae may touch an object at any angle in the whisk cycle. The representation of touch and ...

journal_title：PLoS biology

authors： Moore JD,Mercer Lindsay N,Deschênes M,Kleinfeld D

更新日期：2015-09-22 00:00:00

abstract：:Total internal reflection fluorescence microscopy (TIR-FM) has become a powerful tool for studying clathrin-mediated endocytosis. However, due to difficulties in tracking and quantifying their heterogeneous dynamic behavior, detailed analyses have been restricted to a limited number of selected clathrin-coated pits (C...

journal_title：PLoS biology

authors： Loerke D,Mettlen M,Yarar D,Jaqaman K,Jaqaman H,Danuser G,Schmid SL

更新日期：2009-03-17 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：:Blood vascular networks in vertebrates are essential to tissue survival. Establishment of a fully functional vasculature is complex and requires a number of steps including vasculogenesis and angiogenesis that are followed by differentiation into specialized vascular tissues (i.e., arteries, veins, and lymphatics) and...

journal_title：PLoS biology

authors： Ricard N,Simons M

更新日期：2015-05-15 00:00:00

abstract：:Citizen science is mainstream: millions of people contribute data to a growing array of citizen science projects annually, forming massive datasets that will drive research for years to come. Many citizen science projects implement a "leaderboard" framework, ranking the contributions based on number of records or spec...

journal_title：PLoS biology

authors： Callaghan CT,Rowley JJL,Cornwell WK,Poore AGB,Major RE

更新日期：2019-06-27 00:00:00

abstract：:Myosin VI has been studied in both a monomeric and a dimeric form in vitro. Because the functional characteristics of the motor are dramatically different for these two forms, it is important to understand whether myosin VI heavy chains are brought together on endocytic vesicles. We have used fluorescence anisotropy m...

journal_title：PLoS biology

authors： Altman D,Goswami D,Hasson T,Spudich JA,Mayor S

更新日期：2007-08-01 00:00:00

abstract：:Disease-associated misfolded proteins or proteins damaged due to cellular stress are generally disposed via the cellular protein quality-control system. However, under saturating conditions, misfolded proteins will aggregate. In higher eukaryotes, these aggregates can be transported to accumulate in aggresomes at the ...

journal_title：PLoS biology

authors： Rujano MA,Bosveld F,Salomons FA,Dijk F,van Waarde MA,van der Want JJ,de Vos RA,Brunt ER,Sibon OC,Kampinga HH

更新日期：2006-12-01 00:00:00