Host-parasite interactions and the evolution of gene expression.

abstract：:No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lacto...

journal_title：PLoS biology

authors： Siegal ML

更新日期：2015-02-17 00:00:00

abstract：:Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse model of pancreatic islet cell tumorigenesis can be used to meas...

journal_title：PLoS biology

authors： Du YC,Lewis BC,Hanahan D,Varmus H

更新日期：2007-10-16 00:00:00

abstract：:Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors. To s...

journal_title：PLoS biology

authors： Jeong JH,Lee DK,Liu SM,Chua SC Jr,Schwartz GJ,Jo YH

更新日期：2018-04-24 00:00:00

abstract：:In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analyzing primary chicke...

journal_title：PLoS biology

authors： Richard A,Boullu L,Herbach U,Bonnafoux A,Morin V,Vallin E,Guillemin A,Papili Gao N,Gunawan R,Cosette J,Arnaud O,Kupiec JJ,Espinasse T,Gonin-Giraud S,Gandrillon O

更新日期：2016-12-27 00:00:00

abstract：:Certain bacterial adhesins appear to promote a pathogen's extracellular lifestyle rather than its entry into host cells. However, little is known about the stimuli elicited upon such pathogen host-cell interactions. Here, we report that type IV pili (Tfp)-producing Neisseria gonorrhoeae (P(+)GC) induces an immediate r...

journal_title：PLoS biology

authors： Boettcher JP,Kirchner M,Churin Y,Kaushansky A,Pompaiah M,Thorn H,Brinkmann V,Macbeath G,Meyer TF

更新日期：2010-08-24 00:00:00

abstract：:In Amazonian tropical forests, recent studies have reported increases in aboveground biomass and in primary productivity, as well as shifts in plant species composition favouring fast-growing species over slow-growing ones. This pervasive alteration of mature tropical forests was attributed to global environmental cha...

journal_title：PLoS biology

authors： Chave J,Condit R,Muller-Landau HC,Thomas SC,Ashton PS,Bunyavejchewin S,Co LL,Dattaraja HS,Davies SJ,Esufali S,Ewango CE,Feeley KJ,Foster RB,Gunatilleke N,Gunatilleke S,Hall P,Hart TB,Hernández C,Hubbell SP,Itoh A,

更新日期：2008-03-04 00:00:00

abstract：:The ability to find and consume nutrient-rich diets for successful reproduction and survival is fundamental to animal life. Among the nutrients important for all animals are polyamines, a class of pungent smelling compounds required in numerous cellular and organismic processes. Polyamine deficiency or excess has detr...

journal_title：PLoS biology

authors： Hussain A,Zhang M,Üçpunar HK,Svensson T,Quillery E,Gompel N,Ignell R,Grunwald Kadow IC

更新日期：2016-05-04 00:00:00

abstract：:Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a microscopy-based genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins required for centriole duplication and mitotic PCM recruitment. We analysed 92% of the Droso...

journal_title：PLoS biology

authors： Dobbelaere J,Josué F,Suijkerbuijk S,Baum B,Tapon N,Raff J

更新日期：2008-09-16 00:00:00

abstract：:The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting ...

journal_title：PLoS biology

authors： Karp NA,Meehan TF,Morgan H,Mason JC,Blake A,Kurbatova N,Smedley D,Jacobsen J,Mott RF,Iyer V,Matthews P,Melvin DG,Wells S,Flenniken AM,Masuya H,Wakana S,White JK,Lloyd KC,Reynolds CL,Paylor R,West DB,Svenson KL,

更新日期：2015-05-20 00:00:00

abstract：:Three-dimensional (3D) structural information on many length scales is of central importance in biological research. Excellent methods exist to obtain structures of molecules at atomic, organelles at electron microscopic, and tissue at light-microscopic resolution. A gap exists, however, when 3D tissue structure needs...

journal_title：PLoS biology

authors： Denk W,Horstmann H

更新日期：2004-11-01 00:00:00

abstract：:The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established: tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, sever...

journal_title：PLoS biology

authors： Abascal F,Posada D,Knight RD,Zardoya R

更新日期：2006-05-01 00:00:00

abstract：:The cerebellum has been proposed to be a crucial component in the state estimation process that combines information from motor efferent and sensory afferent signals to produce a representation of the current state of the motor system. Such a state estimate of the moving human arm would be expected to be used when the...

journal_title：PLoS biology

authors： Miall RC,Christensen LO,Cain O,Stanley J

更新日期：2007-11-01 00:00:00

abstract：:Ribosome biogenesis is a major energy-consuming process in the cell that has to be rapidly down-regulated in response to stress or nutrient depletion. The target of rapamycin 1 (Tor1) pathway regulates synthesis of ribosomal RNA (rRNA) at the level of transcription initiation. It remains unclear whether ribosome bioge...

journal_title：PLoS biology

authors： Kos-Braun IC,Jung I,Koš M

更新日期：2017-03-10 00:00:00

abstract：UNLABELLED:Reward-related dopaminergic influences on learning and overt behaviour are well established, but any influence on sensory decision-making is largely unknown. We used functional magnetic resonance imaging (fMRI) while participants judged electric somatosensory stimuli on one hand or other, before being reward...

journal_title：PLoS biology

authors： Pleger B,Ruff CC,Blankenburg F,Klöppel S,Driver J,Dolan RJ

更新日期：2009-07-01 00:00:00

abstract：:Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...

journal_title：PLoS biology

authors： Hoehl S,Markova G

更新日期：2018-12-13 00:00:00

abstract：:The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of d...

journal_title：PLoS biology

authors： Bossuyt W,De Geest N,Aerts S,Leenaerts I,Marynen P,Hassan BA

更新日期：2009-02-24 00:00:00

abstract：:Methanotrophs are ubiquitous bacteria that can use the greenhouse gas methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated methane to the atmosphere. Despite their importance, and in contra...

journal_title：PLoS biology

authors： Ward N,Larsen Ø,Sakwa J,Bruseth L,Khouri H,Durkin AS,Dimitrov G,Jiang L,Scanlan D,Kang KH,Lewis M,Nelson KE,Methé B,Wu M,Heidelberg JF,Paulsen IT,Fouts D,Ravel J,Tettelin H,Ren Q,Read T,DeBoy RT,Seshadri R,S

更新日期：2004-10-01 00:00:00

abstract：:Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several homin...

journal_title：PLoS biology

authors： Fortna A,Kim Y,MacLaren E,Marshall K,Hahn G,Meltesen L,Brenton M,Hink R,Burgers S,Hernandez-Boussard T,Karimpour-Fard A,Glueck D,McGavran L,Berry R,Pollack J,Sikela JM

更新日期：2004-07-01 00:00:00

abstract：:Single-cell imaging, combined with recent advances in image analysis and microfluidic technologies, have enabled fundamental discoveries of cellular responses to chemical perturbations that are often obscured by traditional liquid-culture experiments. Temperature is an environmental variable well known to impact growt...

journal_title：PLoS biology

authors： Knapp BD,Zhu L,Huang KC

更新日期：2020-11-06 00:00:00

abstract：:Australia's iconic Great Barrier Reef (GBR) continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS), losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to reboun...

journal_title：PLoS biology

authors： Hock K,Wolff NH,Ortiz JC,Condie SA,Anthony KRN,Blackwell PG,Mumby PJ

更新日期：2017-11-28 00:00:00

abstract：:Using DNA sequences 5' to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans. This effort encompasses about 10% of all genes identified in this organism. GFP-expre...

journal_title：PLoS biology

authors： Hunt-Newbury R,Viveiros R,Johnsen R,Mah A,Anastas D,Fang L,Halfnight E,Lee D,Lin J,Lorch A,McKay S,Okada HM,Pan J,Schulz AK,Tu D,Wong K,Zhao Z,Alexeyenko A,Burglin T,Sonnhammer E,Schnabel R,Jones SJ,Marra MA,

更新日期：2007-09-01 00:00:00

abstract：:The sperm's crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing circuits that affect the sperm's navigational ...

journal_title：PLoS biology

authors： Hoang HD,Miller MA

更新日期：2017-06-29 00:00:00

abstract：:Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at risk of malaria despite previous exposure to the disease. These traits stem fro...

journal_title：PLoS biology

authors： Zhang X,Alexander N,Leonardi I,Mason C,Kirkman LA,Deitsch KW

更新日期：2019-05-13 00:00:00

abstract：:Obesity is a condition characterized by excess adipose tissue that results from positive energy balance and is the most common metabolic disorder in the industrialized world. The obesity epidemic shows no sign of slowing, and it is increasingly a global problem. Serious clinical problems associated with obesity includ...

journal_title：PLoS biology

authors： Stephens JM

更新日期：2012-01-01 00:00:00

abstract：:A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly ...

journal_title：PLoS biology

authors： Shirangi TR,Dufour HD,Williams TM,Carroll SB

更新日期：2009-08-01 00:00:00

abstract：:PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...

journal_title：PLoS biology

authors： Fiorini N,Canese K,Starchenko G,Kireev E,Kim W,Miller V,Osipov M,Kholodov M,Ismagilov R,Mohan S,Ostell J,Lu Z

更新日期：2018-08-28 00:00:00

abstract：:Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents a significant risk to human health. Plants chemically reduce arsenate to arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in arsenic accumulation in Arabidopsis thaliana allowed us to ide...

journal_title：PLoS biology

authors： Chao DY,Chen Y,Chen J,Shi S,Chen Z,Wang C,Danku JM,Zhao FJ,Salt DE

更新日期：2014-12-02 00:00:00

abstract：:Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...

journal_title：PLoS biology

authors： Turner HL,Pallesen J,Lang S,Bangaru S,Urata S,Li S,Cottrell CA,Bowman CA,Crowe JE Jr,Wilson IA,Ward AB

更新日期：2019-02-04 00:00:00

abstract：:Metabolic reprogramming to fulfill the biosynthetic and bioenergetic demands of cancer cells has aroused great interest in recent years. However, metabolic reprogramming for cancer metastasis has not been well elucidated. Here, we screened a subpopulation of breast cancer cells with highly metastatic capacity to the l...

journal_title：PLoS biology

authors： Lv Y,Wang X,Li X,Xu G,Bai Y,Wu J,Piao Y,Shi Y,Xiang R,Wang L

更新日期：2020-11-13 00:00:00

abstract：:The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na⁺. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F₁F₀-ATP synthase with a novel Na⁺ recognition motif, shared by other human pathogens. Molecular model...

journal_title：PLoS biology

authors： Schulz S,Iglesias-Cans M,Krah A,Yildiz O,Leone V,Matthies D,Cook GM,Faraldo-Gómez JD,Meier T

更新日期：2013-01-01 00:00:00