解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Cell-penetrating peptides, a group of short peptides, can traverse cell membranes to enter cells and thus facilitate the uptake of various molecular cargoes. Thus, they have the potential to become powerful drug delivery systems. The correct identification of peptides as cell-penetrating or non-cell-penetrating would ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1974-5
更新日期:2015-07-01 00:00:00
abstract::Using a radioactive glutamate uptake assay and immunolabeling, we report that single-walled carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), delivered as a colloidal solute, cause an increase in the uptake of extracellular glutamate by astrocytes and an increase in the immunoreactivity...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1970-9
更新日期:2015-07-01 00:00:00
abstract::The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1944-y
更新日期:2015-06-01 00:00:00
abstract::Emerging evidence from laboratory researches has highlighted the bioactivity of food melanoidins and melanoproteins. Whilst such studies have been carried out with different in vitro systems, information about melanoidins absorption and bio-availability are scarce. However, they are generally considered as poorly abso...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-1951-z
更新日期:2015-06-01 00:00:00
abstract::We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1969-2
更新日期:2015-06-01 00:00:00
abstract::The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1935-z
更新日期:2015-05-01 00:00:00
abstract::D-Aspartate (D-Asp) has important physiological functions, and recent studies have shown that substantial amounts of free D-Asp are present in a wide variety of mammalian tissues and cells. Biosynthesis of D-Asp has been observed in several cultured rat cell lines, and a murine gene (glutamate-oxaloacetate transaminas...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1926-0
更新日期:2015-05-01 00:00:00
abstract::Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1940-2
更新日期:2015-05-01 00:00:00
abstract::Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1903-z
更新日期:2015-04-01 00:00:00
abstract::The polyamines spermidine and spermine, and their precursor putrescine, have been shown to play an important role in cell migration, proliferation, and differentiation. Because of their polycationic property, polyamines are traditionally thought to be involved in DNA replication, gene expression, and protein translati...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1879-8
更新日期:2015-03-01 00:00:00
abstract::The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1887-8
更新日期:2015-03-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1894-9
更新日期:2015-03-01 00:00:00
abstract::The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multim...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1897-6
更新日期:2015-03-01 00:00:00
abstract::Interferon tau (IFNT) was discovered as the pregnancy recognition signal in ruminants, but is now known to have a plethora of physiological functions in the mammalian uterus. The mammalian uterus includes, from the outer surface to the lumen, the serosa, myometrium and endometrium. The endometrium consists of the lumi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1905-x
更新日期:2015-03-01 00:00:00
abstract::The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1902-0
更新日期:2015-02-01 00:00:00
abstract::Chiral dehydroamino acid building blocks are versatile starting materials for the preparation of optically active unusual amino acids and other compounds of pharmacological interest. Herein we disclose the expedient preparation of dehydroalanines (ΔAla) equipped with oxazolidin-2-one (Oxd) chiral auxiliaries, Ts-Oxd-Δ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1839-3
更新日期:2014-12-01 00:00:00
abstract::Amino acids are potent regulators of muscle protein synthesis and breakdown and have received considerable attention for the treatment of muscle wasting conditions. Arginine is critically involved in numerous physiological functions including providing substrate for the production of creatine, urea and nitric oxide (N...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1815-y
更新日期:2014-12-01 00:00:00
abstract::Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short peptide sequence ligated to a lipidic acid. Nine ultrashort catio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1806-z
更新日期:2014-11-01 00:00:00
abstract::The kinetic mechanism of the transport catalyzed by the human glutamine/neutral amino acid transporter hASCT2 over-expressed in P. pastoris was determined in proteoliposomes by pseudo-bi-substrate kinetic analysis of the Na(+)-glutamineex/glutaminein transport reaction. A random simultaneous mechanism resulted from th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1808-x
更新日期:2014-11-01 00:00:00
abstract::Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that have an effect on gene regulation. The naturally occurring cyclic depsipeptide FK228 containing disulfide and Largazole possessing thioester functionalities act as pro-drugs and share the same HDAC inhibition mechanism in cell. ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1800-5
更新日期:2014-10-01 00:00:00
abstract::Antimicrobial peptides (AMPs) constitute a diverse class of naturally occurring or synthetic antimicrobial molecules that have potential for use in the treatment of drug-resistant infections. Several undesirable properties of AMPs, however, may ultimately hinder their development as antimicrobial agents. Thus, new syn...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1761-8
更新日期:2014-09-01 00:00:00
abstract::The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of g...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1764-5
更新日期:2014-09-01 00:00:00
abstract::A thioalkylation procedure, which uses molecular sieves to promote the reaction, was exploited to provide peptides with useful functional groups (lipidic moieties), naturally occurring on proteins as post-translational modifications. The procedure was further implemented to synthesize tailor-made lipidated peptides, i...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1742-y
更新日期:2014-08-01 00:00:00
abstract::The sulfur-containing excitatory amino acid (EAA) L-cysteine sulfinic acid (CSA), a neurotransmitter candidate, is endogenously synthesized from L-cysteine (Cys). Exogenous Cys administration into the brain produces cardiovascular effects; these effects likely occur via synaptic stimulation of central nervous system (...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1733-z
更新日期:2014-07-01 00:00:00
abstract::Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this revi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1710-6
更新日期:2014-06-01 00:00:00
abstract::Selective removal of protecting groups under different cleavage mechanisms could be an asset in peptide synthesis, since it provides the feasibility to incorporate different functional groups in similar reactive centres. However, selective protection/deprotection of orthogonal protecting groups in peptides is still ch...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1696-0
更新日期:2014-05-01 00:00:00
abstract::M33 is a branched peptide currently under preclinical characterization for the development of a new antibacterial drug against gram-negative bacteria. Here, we report its pegylation at the C-terminus of the three-lysine-branching core and the resulting increase in stability to Pseudomonas aeruginosa elastase. This pro...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1686-2
更新日期:2014-05-01 00:00:00
abstract::IEF is often used in multidimensional shotgun proteomics and the narrow range of 3.5-4.5 is the recommended pH interval for the fractionation of tryptic peptides. Usually, even if IEF is performed in IPG strip with a narrow range pH, the entire sample must be loaded onto the strip, including the "out of IPG range" pep...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1720-4
更新日期:2014-05-01 00:00:00
abstract::The study of nanomaterial/biomolecule interface is an important emerging field in bionanoscience, and additionally in many biological processes such as hard-tissue growth and cell-surface adhesion. To have a deeper understanding of the amino acids/gold nanoparticle assemblies, the adsorption of these amino acids on th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1642-6
更新日期:2014-04-01 00:00:00
abstract::Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1671-9
更新日期:2014-04-01 00:00:00
abstract::The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1650-6
更新日期:2014-04-01 00:00:00
abstract::Among the large family of cyclodepsipeptides, the simplest members are the cyclodidepsipeptides which have an ester group and an amide group in the same six-membered ring. To point out the pharmacological potential of this class of compounds, the present article reviews structure, isolation, synthesis and biological p...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1666-6
更新日期:2014-04-01 00:00:00
abstract::Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1517-x
更新日期:2014-03-01 00:00:00
abstract::The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1605-y
更新日期:2014-03-01 00:00:00
abstract::The effect of up-regulation of putrescine (Put) production by genetic manipulation on the turnover of spermidine (Spd) and spermine (Spm) was investigated in transgenic cells of poplar (Populus nigra × maximowiczii) and seedlings of Arabidopsis thaliana. Several-fold increase in Put production was achieved by expressi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1581-2
更新日期:2014-03-01 00:00:00
abstract::Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the prot...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1589-7
更新日期:2014-03-01 00:00:00
abstract::S-adenosylmethionine (SAM), a major substrate in 1-C metabolism is a common precursor in the biosynthetic pathways of polyamines and ethylene, two important plant growth regulators, which exhibit opposing developmental effects, especially during fruit ripening. However, the flux of various substrates including SAM int...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1624-8
更新日期:2014-03-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1628-4
更新日期:2014-02-01 00:00:00
abstract::Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA). Growing Angus stee...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1622-x
更新日期:2014-02-01 00:00:00
abstract::The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additiona...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1599-5
更新日期:2013-12-01 00:00:00