Abstract:
:Using a radioactive glutamate uptake assay and immunolabeling, we report that single-walled carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), delivered as a colloidal solute, cause an increase in the uptake of extracellular glutamate by astrocytes and an increase in the immunoreactivity of the glutamate transporter GLAST on their cell surface, which is likely a consequence of an increase in the immunoreactivity of glial fibrillary acidic protein. Additional corollary is that astrocytes exposed to SWCNT-PEG became larger and stellate, morphological characteristics of maturation and heightened activity of these glial cells. These results imply that SWCNT-PEG could potentially be used as a viable candidate for neural prosthesis applications, perhaps to alleviate the death toll of neurons due to glutamate excitotoxicity, a pathological process observed in brain and spinal cord injuries.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Gottipati MK,Bekyarova E,Haddon RC,Parpura Vdoi
10.1007/s00726-015-1970-9subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1379-88issue
7eissn
0939-4451issn
1438-2199journal_volume
47pub_type
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