Abstract:
:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes and another two enzymes, glutamate semialdehyde dehydrogenase and ornithine aminotransferase. Since R-Y121B·cho cells have all the urea cycle enzymes, two other enzyme activities were determined. The activities of ornithine aminotransferase and glutamate semialdehyde dehydrogenase were similar in R-Y117B·cho and its parental R-Y121B·cho cells, but R-Y117B·cho cells had higher conversion of glutamate to arginine than parental cells.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Yamamoto K,Niwa Adoi
10.1007/BF00807328subject
Has Abstractpub_date
1996-09-01 00:00:00pages
263-71issue
3eissn
0939-4451issn
1438-2199journal_volume
10pub_type
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