Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides.

abstract：:The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...

journal_title：Amino acids

authors： Ramkumar S,Fujii N,Sakaue H,Fujii N,Thankappan B,kumari RP,Natarajaseenivasan K,Anbarasu K

更新日期：2015-05-01 00:00:00

abstract：:This is the third special issue focused on "Transglutaminases" that is now available on this journal and dedicated to one of the pioneers of these enzymes, John Edward Folk, who died December 2010 [see in this issue Beninati et al. 2012a]. The first edition, "Polyamines and Transglutaminases" was published in Amino Ac...

journal_title：Amino acids

authors： Beninati S,Facchiano F,Piacentini M

更新日期：2013-01-01 00:00:00

abstract：:Hippocampus trimaculatus is one of the most heavily traded seahorse species for traditional medicine purposes in many countries. In the present study, we showed neuroprotective effects of peptide derived from H. trimaculatus against amyloid-β42 (Aβ42) toxicity which are central to the pathogenesis of Alzheimer's disea...

journal_title：Amino acids

authors： Pangestuti R,Ryu B,Himaya S,Kim SK

更新日期：2013-08-01 00:00:00

abstract：:Filamentous fungi of the genusHypocrea were grown on malt extract/peptone agar, the mycelia were extracted with dichloromethane/methanol, and the extracts were totally hydrolyzed with 6 N HCl (110°C, 24 h). The amino acids (AA) released from peptides were converted into theirN(O)-pen-tafluoropropionyl 1-propyl esters ...

journal_title：Amino acids

authors： Brückner H,Maisch J,Reinecke C,Kimonyo A

更新日期：1991-06-01 00:00:00

abstract：:The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, euk...

journal_title：Amino acids

authors： Park MH,Nishimura K,Zanelli CF,Valentini SR

更新日期：2010-02-01 00:00:00

abstract：:Pyridoxamine (PM) has long been known to inhibit protein glycation via various mechanisms of action. One such mechanism involves the scavenging of carbonyl compounds with glycating ability. Despite the abundant literature on this topic, few quantitative kinetic studies on the processes involved have been reported. In ...

journal_title：Amino acids

authors： Adrover M,Vilanova B,Frau J,Muñoz F,Donoso J

更新日期：2009-03-01 00:00:00

abstract：:D-Asp-containing proteins have been implicated in many aging-related diseases. To clarify the role of D-Asp-containing proteins in such diseases, we developed a screening system for these proteins using a D-aspartyl endopeptidase that specifically cleaves the proteins at the C-terminus. The digested proteins were dete...

journal_title：Amino acids

authors： Sakai-Kato K,Kinouchi T,Fujii N,Imai K,Utsunomiya-Tate N

更新日期：2009-01-01 00:00:00

abstract：:Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT(1)R and BKRB(1) or BKRB(2) G-protein-coupled receptors (GPCRs). Here we synthesized peptides P15 and P13 corresponding to...

journal_title：Amino acids

authors： Lopes DD,Vieira RF,Malavolta L,Poletti EF,Shimuta SI,Paiva AC,Schreier S,Oliveira L,Nakaie CR

更新日期：2013-03-01 00:00:00

abstract：:A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...

journal_title：Amino acids

authors： Kil JS,Jeong SO,Chung HT,Pae HO

更新日期：2017-04-01 00:00:00

abstract：:The increased protein requirement of endurance athletes may be related to the need to replace exercise-induced oxidative losses, especially of the branched-chain amino acids (BCAA). However, it is unknown if non-essential amino acids (NEAA) influence the requirement for essential amino acids (EAA) during post-exercise...

journal_title：Amino acids

authors： Kato H,Volterman KA,West DWD,Suzuki K,Moore DR

更新日期：2018-12-01 00:00:00

abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

journal_title：Amino acids

authors： Declerck V,Aitken DJ

更新日期：2011-08-01 00:00:00

abstract：:This paper analyses the presence of and changes in free amino acids and biogenic amines in red and white muscle of bigeye tuna during storage in controlled atmospheres with 2 gas mixes containing different concentrations of CO(2) and O(2). Levels of amines were generally higher in white than in red muscle, with the ex...

journal_title：Amino acids

authors： Ruiz-Capillas C,Moral A

更新日期：2004-03-01 00:00:00

abstract：:Reports on nucleobase-containing chiral peptides (both natural and artificial) and achiral pseudopeptides are reviewed. Their synthesis, structural features, DNA and RNA-binding ability, as well as some other interesting applications which make them promising diagnostic/therapeutic agents of great importance in many a...

journal_title：Amino acids

authors： Roviello GN,Benedetti E,Pedone C,Bucci EM

更新日期：2010-06-01 00:00:00

abstract：:In the article (Romek et al. 2013) we reported the values of δ15N (‰) and δ13C (‰) obtained by. ...

journal_title：Amino acids

authors： Romek KM,Julien M,Frasquet-Darrieux M,Tea I,Antheaume I,Hankard R,Robins RJ

更新日期：2018-01-01 00:00:00

abstract：:Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...

journal_title：Amino acids

authors： Schatzmann-Turhani D,Greber-Platzer S,Cairns N,Lubec G

更新日期：1999-01-01 00:00:00

abstract：:For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

journal_title：Amino acids

authors： Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

更新日期：2019-11-01 00:00:00

abstract：:Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and ...

journal_title：Amino acids

authors： Harro J

更新日期：2006-10-01 00:00:00

abstract：:Ocular ischemia resulting from perfusion disturbances may play a major role in initiation of glaucoma. Possibly secondary to ischemia autoimmunogenic events are activated in glaucoma patients with increased prevalence of systemic autoimmune diseases. The determination of potential molecular markers in blood leukocytes...

journal_title：Amino acids

authors： Golubnitschaja O,Wunderlich K,Decker C,Mönkemann H,Schild HH,Flammer J

更新日期：2002-01-01 00:00:00

abstract：:The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...

journal_title：Amino acids

authors： Xu Y,Qiang X,Xing L,Wang H,Zhang J,Zhang F,Caliskan B,Wang M,Qiu Z

更新日期：2018-08-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:Spermine oxidase (SMO) was discovered much more recently than other enzymes involved in polyamine metabolism; this review summarizes 10 years of researches on this enzyme. Spermine oxidase (SMO) is a FAD-dependent enzyme that specifically oxidizes spermine (Spm) and plays a dominant role in the highly regulated mammal...

journal_title：Amino acids

authors： Cervelli M,Amendola R,Polticelli F,Mariottini P

更新日期：2012-02-01 00:00:00

abstract：:The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed...

journal_title：Amino acids

authors： Otvos L Jr,Vetter SW,Koladia M,Knappe D,Schmidt R,Ostorhazi E,Kovalszky I,Bionda N,Cudic P,Surmacz E,Wade JD,Hoffmann R

更新日期：2014-04-01 00:00:00

abstract：:Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...

journal_title：Amino acids

authors： Reiken SR,Briedis DM

更新日期：1992-10-01 00:00:00

abstract：:Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...

journal_title：Amino acids

authors： Grosvenor AJ,Morton JD,Dyer JM

更新日期：2010-06-01 00:00:00

abstract：:Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...

journal_title：Amino acids

authors： Akasaka N,Fujiwara S

更新日期：2020-02-01 00:00:00

abstract：:The transient receptor potential channels TRPV2 and TRPV5 belong to the vanilloid TRP subfamily. TRPV2 is highly similar to TRPV1 and shares many common properties with it. TRPV5 (and also its homolog TRPV6) is a rather distinct member of the TRPV subfamily. It is distant for being strictly Ca(2+)-selective and featur...

journal_title：Amino acids

authors： Holakovska B,Grycova L,Bily J,Teisinger J

更新日期：2011-02-01 00:00:00

abstract：:The intestine is not only critical for the absorption of nutrients, but also interacts with a complex external milieu. Most foreign antigens enter the body through the digestive tract. Dietary amino acids are major fuels for the small intestinal mucosa, as well as important substrates for syntheses of intestinal prote...

journal_title：Amino acids

authors： Wang WW,Qiao SY,Li DF

更新日期：2009-05-01 00:00:00

abstract：:Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated w...

journal_title：Amino acids

authors： Yuan LQ,Lu Y,Luo XH,Xie H,Wu XP,Liao EY

更新日期：2007-01-01 00:00:00

abstract：:The human organism is exposed to numerous processes that generate reactive oxygen species (ROS). ROS may directly or indirectly cause oxidative modification and damage of proteins. Protein oxidation is regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to Alzheimer's ...

journal_title：Amino acids

authors： Pietzsch J,Bergmann R,Wuest F,Pawelke B,Hultsch C,van den Hoff J

更新日期：2005-12-01 00:00:00

abstract：:Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

journal_title：Amino acids

authors： Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

更新日期：2013-01-01 00:00:00