解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Oxidative stress, an excess of reactive oxygen species (ROS), may lead to oxidative post-translational modifications of proteins resulting in the cleavage of the peptide backbone, known as α-amidation, and formation of fragments such as peptide amides and α-ketoacyl peptides (α-KaP). In this study, we first compared d...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-020-02902-8
更新日期:2020-10-01 00:00:00
abstract::The G protein-coupled receptor kinase (GRK) family consists of seven cytosolic serine/threonine (Ser/Thr) protein kinases, and among them, GRK2 is involved in the regulation of an enormous range of both G protein-coupled receptors (GPCRs) and non-GPCR substrates that participate in or regulate many critical cellular p...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-020-02864-x
更新日期:2020-07-01 00:00:00
abstract::Gamma-aminobutyric acid (GABA) biosynthesis depended to a great extent on the biotransformation characterization of glutamate decarboxylase (GAD) and process conditions. In this paper, the enhancing effect of D101 macroporous adsorption resin (MAR) on the GABA production was investigated based on the whole-cell biotra...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-020-02850-3
更新日期:2020-05-01 00:00:00
abstract::Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524-1548)-RAD51(241-260) complex...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02813-3
更新日期:2020-03-01 00:00:00
abstract::Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02816-0
更新日期:2020-03-01 00:00:00
abstract::Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02720-7
更新日期:2020-02-01 00:00:00
abstract::Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02759-6
更新日期:2020-02-01 00:00:00
abstract::For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02800-8
更新日期:2019-11-01 00:00:00
abstract::Increased intracellular cysteine poses a potential danger to cells due to the high ability of cysteine to reduce free iron and promote the Fenton reaction. Here, we studied ways to maintain cysteine homeostasis in E. coli cells while inhibiting protein synthesis with valine or chloramphenicol. When growing wild-type b...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02795-2
更新日期:2019-11-01 00:00:00
abstract::A novel recombinant disintegrin, vicrostatin (VCN), displays high binding affinity to a broad range of human integrins in substantial competitive biological advantage over other integrin-based antagonists. In this study, we synthesized a new 64Cu-labeled VCN probe and evaluated its imaging properties for prostate canc...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02794-3
更新日期:2019-11-01 00:00:00
abstract::The role of pH-dependent ionic structures of L-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, L-amino acids performed well, even better than corresponding base catalysts and provided the β-amino c...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02798-z
更新日期:2019-11-01 00:00:00
abstract::L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02783-6
更新日期:2019-11-01 00:00:00
abstract::This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02769-4
更新日期:2019-09-01 00:00:00
abstract::Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02767-6
更新日期:2019-09-01 00:00:00
abstract::Dietary polyamines and amino acids (AAs) are crucial for human growth, development, reproduction, and health. However, the scientific literature shows large variations in polyamine and AA concentrations among major staple foods of plant origin, and there is a scarcity of information regarding their complete compositio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02751-0
更新日期:2019-08-01 00:00:00
abstract::Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02762-x
更新日期:2019-08-01 00:00:00
abstract::We recently reported that dietary supplementation with L-proline (proline) during gestation improved embryonic survival in C57BL/6J mice. The objective of the present study was to test the hypothesis that the effect of maternal proline supplementation on embryonic survival can be carried forward to the first generatio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02717-2
更新日期:2019-05-01 00:00:00
abstract::Skin is made up of mainly collagen type I and its structure is stabilised by the formation of covalent immature and mature crosslinks. In this study, collagen immature crosslink hydroxylysinonorleucine (HLNL) was isolated from bovine skin in high purity using two sequential purification steps. These consisted of prepa...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02708-3
更新日期:2019-04-01 00:00:00
abstract::Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-02690-2
更新日期:2019-04-01 00:00:00
abstract::Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy hu...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-02693-z
更新日期:2019-03-01 00:00:00
abstract::Anticancer peptides (ACPs) are biologically anticancer active molecules that are produced by mammals, plants, insects and microorganisms. Here, a new peptide (TC22) with the amino acid sequence MTVVLLLIVLPLLGGVHSSGIL was identified and characterized from the beetle Tribolium castaneum. We found it inhibited the growth...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2666-8
更新日期:2019-02-01 00:00:00
abstract::This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise...
journal_title:Amino acids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00726-018-2655-y
更新日期:2019-02-01 00:00:00
abstract::This study was conducted to evaluate the anti-obesity effects of long-term taurine supplementation in a mild obese ICR mouse model and to study the mechanism by which taurine induces weight loss. Three groups of male ICR mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with 2% taurine in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2659-7
更新日期:2019-02-01 00:00:00
abstract::Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as cau...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2647-y
更新日期:2019-01-01 00:00:00
abstract::The increased protein requirement of endurance athletes may be related to the need to replace exercise-induced oxidative losses, especially of the branched-chain amino acids (BCAA). However, it is unknown if non-essential amino acids (NEAA) influence the requirement for essential amino acids (EAA) during post-exercise...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2639-y
更新日期:2018-12-01 00:00:00
abstract::The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2637-0
更新日期:2018-11-01 00:00:00
abstract::Pseudomonas aeruginosa is particularly difficult to treat because it possesses a variety of resistance mechanisms and because it often forms biofilms. Antimicrobial peptides represent promising candidates for future templates of antibiotic-resistant bacterial infections due to their unique mechanism of antimicrobial a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2625-4
更新日期:2018-10-01 00:00:00
abstract::The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2616-5
更新日期:2018-10-01 00:00:00
abstract::In yeast, toxicity of acetaminophen (APAP), a frequently used analgesic and antipyretic drug, depends on ubiquitin-controlled processes. Previously, we showed a remarkable overlap in toxicity profiles between APAP and tyrosine, and a similarity with drugs like rapamycin and quinine, which induce degradation of the ami...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2613-8
更新日期:2018-10-01 00:00:00
abstract::The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2589-4
更新日期:2018-08-01 00:00:00
abstract::Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2588-5
更新日期:2018-08-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with 64Cu, and evaluated the feasibility of using 64Cu-Di-San A1 for PET imaging of ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2566-y
更新日期:2018-07-01 00:00:00
abstract::One pathogenic mechanism of ethanol-induced liver injury is the excessive production of reactive oxygen species (ROS), which may result in alcoholic liver disease (ALD) characterized by cell death due to necrosis and apoptosis. Taurine was proved to protect against liver damage. However, whether taurine attenuates eth...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2561-3
更新日期:2018-07-01 00:00:00
abstract::This article deals with the synthesis in solid phase and characterization of a nucleoamino amide, based on a phenylalaninamide moiety which was N-conjugated to a thymine nucleobase. In analogy to the natural nucleobase-amino acid conjugates, endowed with a wide range of biological properties, the nucleoamino amide int...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2562-2
更新日期:2018-07-01 00:00:00
abstract::The sulfur-containing amino acid, taurine (Tau), regulates glucose and lipid homeostasis under normal, pre- and diabetic conditions. Here, we aimed to verify whether Tau supplementation exerts its beneficial effects against obesity, hyperglycemia and alterations in islet functions, in leptin-deficient obese (ob/ob), o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2553-3
更新日期:2018-06-01 00:00:00
abstract::Beyond nigrostriatal dopaminergic system, the noradrenergic locus coeruleus (LC/NE) neurons are also degenerated in patients with Parkinson's disease (PD), the second most common neurodegenerative disorder. We previously reported that microglia-mediated neuroinflammation contributes to LC/NE neurodegeneration. The pur...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2547-1
更新日期:2018-05-01 00:00:00
abstract::Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and e...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2550-6
更新日期:2018-05-01 00:00:00
abstract::Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2524-0
更新日期:2018-04-01 00:00:00
abstract::This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholin...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2515-1
更新日期:2018-02-01 00:00:00
abstract::The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2499-x
更新日期:2018-01-01 00:00:00