A fusion antitumor peptide regulates proliferation and apoptosis of endothelial cells.

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine tota...

journal_title：Amino acids

authors： Hill CA,Harris RC,Kim HJ,Harris BD,Sale C,Boobis LH,Kim CK,Wise JA

更新日期：2007-02-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide...

journal_title：Amino acids

authors： Striese F,Sihver W,Gao F,Bergmann R,Walther M,Pietzsch J,Steinbach J,Pietzsch HJ

更新日期：2018-10-01 00:00:00

abstract：:We performed sensory evaluations on 141 bottles of sake and analyzed the relationship between the D-amino acid concentrations, and the taste of the sake using principal component analysis, which yielded seven principal components (PC1-7) that explained 100 % of the total variance in the data. PC1, which explains 33.6 ...

journal_title：Amino acids

authors： Okada K,Gogami Y,Oikawa T

更新日期：2013-02-01 00:00:00

abstract：:Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...

journal_title：Amino acids

authors： Kurl RN,Verney E,Sidransky H

更新日期：1993-06-01 00:00:00

abstract：:Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide,...

journal_title：Amino acids

authors： Blachier F,Mariotti F,Huneau JF,Tomé D

更新日期：2007-11-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functi...

journal_title：Amino acids

authors： Zanelli CF,Valentini SR

更新日期：2007-08-01 00:00:00

abstract：:A variety of alpha-amino acids are enantioresolved for the first time on naphthylethylcarbamate-beta-cyclodextrin bonded phases (i.e., SN- and RN-beta-CD) using the acetonitrile-based mobile phase after their pre-column derivatization with phenyl isothiocyanate in alkaline medium. The resolution is better obtained on ...

journal_title：Amino acids

authors： Chen S

更新日期：2004-06-01 00:00:00

abstract：:This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholin...

journal_title：Amino acids

authors： Lenis YY,Elmetwally MA,Tang W,Satterfield C,Dunlap K,Wu G,Bazer FW

更新日期：2018-02-01 00:00:00

abstract：:The activity of lysine decarboxylase was studied in 3-day-old soybean (Glycine max (L.) Meer cv. Sakai) seedlings also in relation to light conditions. Lysine decarboxylase activity was mainly localized in the roots and to a lesser extent in the hypocotyls and was detectable in both the soluble and particulate fractio...

journal_title：Amino acids

authors： Ohe M,Scoccianti V,Bagni N,Tassoni A,Matsuzaki S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Chemo-therapeutic treatment of glioma patients has minor success. Little is known about mechanisms of a pronounced resistance of gliomas towards actual therapies, yet. ABC-1 belongs to the group of transporters known to be involved in the export of hydrophobic substances and vascular regulation. This study in...

journal_title：Amino acids

authors： Trog D,Moenkemann H,Haertel N,Schüller H,Golubnitschaja O

更新日期：2005-03-01 00:00:00

abstract：:Skin collagen metabolism abnormalities induced by ultraviolet (UV) radiation are the major causes of skin photoaging. It has been shown that the one-time exposure of UV irradiation decreases procollagen mRNA expression in dermis and that chronic UV irradiation decreases collagen amounts and induces wrinkle formation. ...

journal_title：Amino acids

authors： Murakami H,Shimbo K,Inoue Y,Takino Y,Kobayashi H

更新日期：2012-06-01 00:00:00

abstract：:The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...

journal_title：Amino acids

authors： Olma A,Lasota A,Kudaj A

更新日期：2012-06-01 00:00:00

abstract：:Detailed knowledge of the composition of protein complexes is crucial for the understanding of their structure and function; however, appropriate techniques for compositional analyses of complexes largely rely on elaborate tagging, immunoprecipitation, cross-linking and purification strategies. The proteasome is a pro...

journal_title：Amino acids

authors： Sessler N,Krug K,Nordheim A,Mordmüller B,Macek B

更新日期：2012-09-01 00:00:00

abstract：:The G protein-coupled receptor kinase (GRK) family consists of seven cytosolic serine/threonine (Ser/Thr) protein kinases, and among them, GRK2 is involved in the regulation of an enormous range of both G protein-coupled receptors (GPCRs) and non-GPCR substrates that participate in or regulate many critical cellular p...

journal_title：Amino acids

authors： Kang JH,Toita R,Kawano T,Murata M,Asai D

更新日期：2020-07-01 00:00:00

abstract：:The N-terminal 1-34 fragment of parathyroid hormone (PTH) is fully active in vitro and in vivo and it can reproduce all biological responses characteristic of the native intact PTH. Recently, analogues of PTH(1-11) fragments with helicity-enhancing substitutions have been demonstrated to yield potent analogues of PTH(...

journal_title：Amino acids

authors： Caporale A,Sturlese M,Schievano E,Mammi S,Peggion E

更新日期：2010-11-01 00:00:00

abstract：:The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...

journal_title：Amino acids

authors： Suryawan A,O'Connor PM,Bush JA,Nguyen HV,Davis TA

更新日期：2009-05-01 00:00:00

abstract：:Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...

journal_title：Amino acids

authors： Greifenhagen U,Frolov A,Hoffmann R

更新日期：2015-05-01 00:00:00

abstract：:A simple and efficient one-pot procedure that enables rapid access to orthogonally protected N,N'-diaminoalkylated basic amino acid building blocks fully compatible with standard Boc and Fmoc solid-phase peptide synthesis is reported. Described synthetic approach includes double reductive alkylation of N (α)-protected...

journal_title：Amino acids

authors： Pitteloud JP,Bionda N,Cudic P

更新日期：2013-02-01 00:00:00

abstract：:In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

journal_title：Amino acids

authors： Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

更新日期：2010-11-01 00:00:00

abstract：:The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...

journal_title：Amino acids

authors： Cervantes Cianca RC,Baptista MS,Lopes VR,Vasconcelos VM

更新日期：2012-06-01 00:00:00

abstract：:Two experiments were conducted to evaluate the effects of dietary supplementation with Astragalus polysaccharide (APS) on growth performance, apparent ileal digestibilities (AID) of amino acids (AA), and their serum concentrations in early weaned piglets. In Exp. 1, 60 pigs were weaned at 21 days of age (BW 7.35 +/- 0...

journal_title：Amino acids

authors： Yin FG,Liu YL,Yin YL,Kong XF,Huang RL,Li TJ,Wu GY,Hou Y

更新日期：2009-07-01 00:00:00

abstract：:Zinc exhibits antidepressant-like activity in preclinical tests/models. Moreover, zinc homeostasis is implicated in the pathophysiology of affective disorders. The aim of the present study was to examine the effect of chronic zinc, citalopram and imipramine intraperitoneal administration on the presynaptic and extrace...

journal_title：Amino acids

authors： Sowa-Kućma M,Kowalska M,Szlósarczyk M,Gołembiowska K,Opoka W,Baś B,Pilc A,Nowak G

更新日期：2011-01-01 00:00:00

abstract：:How to enhance fruit tolerance to cold stress is an important biological interest. In this paper, we found that mango (Mangifera indica L.) fruit treated with 10 μM brassinolide (BL) showed a higher tolerance to cold temperature of 5 °C. Further, we compared the changes in expression profiles of plasma membrane (PM) p...

journal_title：Amino acids

authors： Li B,Zhang C,Cao B,Qin G,Wang W,Tian S

更新日期：2012-12-01 00:00:00

abstract：:The translation elongation factor eIF5A is conserved through evolution and is necessary to rescue the ribosome during translation elongation of polyproline-containing proteins. Although the site of eIF5A binding to the ribosome is known, no systematic analysis has been performed so far to determine the important resid...

journal_title：Amino acids

authors： Barbosa NM,Boldrin PE,Rossi D,Yamamoto PA,Watanabe TF,Serrão VH,Hershey JW,Fraser CS,Valentini SR,Zanelli CF

更新日期：2016-10-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:Knowledge of the subcellular location of a protein provides valuable information about its function, possible interaction with other proteins and drug targetability, among other things. The experimental determination of a protein's location in the cell is expensive, time consuming and open to human error. Fast and acc...

journal_title：Amino acids

authors： Mooney C,Cessieux A,Shields DC,Pollastri G

更新日期：2013-08-01 00:00:00

abstract：:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. T...

journal_title：Amino acids

authors： Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson A

更新日期：1999-01-01 00:00:00

abstract：:In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...

journal_title：Amino acids

authors： Inbar E,Canepa GE,Carrillo C,Glaser F,Suter Grotemeyer M,Rentsch D,Zilberstein D,Pereira CA

更新日期：2012-01-01 00:00:00