Abstract:
:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gly-pro in urine. 24 hour urine samples were collected from 27 old people (86 +/- 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7 mumol/mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson Adoi
10.1007/BF01366930subject
Has Abstractpub_date
1999-01-01 00:00:00pages
315-22issue
3eissn
0939-4451issn
1438-2199journal_volume
17pub_type
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