Abstract:
:In order to adapt to ever changing environmental conditions, bacteria sense environmental stimuli, and convert them into signals that are transduced intracellularly. Several mechanisms have evolved by which receptors transmit signals across the cytoplasmic membrane. Stimulus perception may trigger receptor dimerization and/or conformational changes. Another mechanism involves the proteolytic procession of a receptor whereby a diffusible cytoplasmic protein is generated. Finally, there is increasing evidence that transport proteins play an important role in transducing signals across the membrane. Transport proteins either directly translocate signaling molecules into the cytoplasm, or transmit information via conformational changes to their interacting partners such as membrane-integrated or soluble components of signal transduction cascades. Employing transport proteins as sensors and regulators of signal transduction represents a sophisticated way of interconnecting metabolic flux and transcriptional regulation in cells.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Tetsch L,Jung Kdoi
10.1007/s00726-009-0235-xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
467-77issue
3eissn
0939-4451issn
1438-2199journal_volume
37pub_type
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