The non-protein amino acid β-N-methylamino-L-alanine in Portuguese cyanobacterial isolates.

abstract：:When considering protein phosphorylation in bacteria, phosphorylation of aspartic acid and histidine residues mediated by the two-component systems is the first to spring to mind. And yet other phosphorylation systems have been described in bacteria in the past 20 years including eukaryotic-like serine/threonine kinas...

journal_title：Amino acids

authors： Bechet E,Guiral S,Torres S,Mijakovic I,Cozzone AJ,Grangeasse C

更新日期：2009-09-01 00:00:00

abstract：:Anticancer peptides (ACPs) are biologically anticancer active molecules that are produced by mammals, plants, insects and microorganisms. Here, a new peptide (TC22) with the amino acid sequence MTVVLLLIVLPLLGGVHSSGIL was identified and characterized from the beetle Tribolium castaneum. We found it inhibited the growth...

journal_title：Amino acids

authors： Liu XD,Zhang FX,Qin ZH,Shan H

更新日期：2019-02-01 00:00:00

abstract：:Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

journal_title：Amino acids

authors： Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

更新日期：2013-01-01 00:00:00

abstract：:Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...

journal_title：Amino acids

authors： Greifenhagen U,Frolov A,Hoffmann R

更新日期：2015-05-01 00:00:00

abstract：:Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...

journal_title：Amino acids

authors： Militante JD,Lombardini JB

更新日期：1998-01-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophe...

journal_title：Amino acids

authors： Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri K

更新日期：2007-01-01 00:00:00

abstract：:In this study, an optically active diamine, N,N'-(pyromellitoyl)-bis{N-[4(4-aminophenoxy)phenyl]-2-(4-methyl)pentanamide} (1) containing amino acid L-leucine was prepared in three steps. The step-growth polymerization of this chiral diamine with several diisocyanates in room temperature ionic liquid (IL), 1,3-dipropyl...

journal_title：Amino acids

authors： Mallakpour S

更新日期：2011-02-01 00:00:00

abstract：:We recently reported that dietary supplementation with L-proline (proline) during gestation improved embryonic survival in C57BL/6J mice. The objective of the present study was to test the hypothesis that the effect of maternal proline supplementation on embryonic survival can be carried forward to the first generatio...

journal_title：Amino acids

authors： Liu N,Dai Z,Zhang Y,Jia H,Chen J,Sun S,Wu G,Wu Z

更新日期：2019-05-01 00:00:00

abstract：:In plasma and serum, the presence of high-abundance proteins can overwhelm the signals of low-abundance proteins, which then become undetectable either by two-dimensional gels or chromatographic techniques. Therefore, depletion of abundant proteins is a prerequisite to detect low-abundance components. Furthermore, the...

journal_title：Amino acids

authors： Millioni R,Puricelli L,Iori E,Tessari P

更新日期：2008-04-01 00:00:00

abstract：:Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...

journal_title：Amino acids

authors： Craveur P,Joseph AP,Poulain P,de Brevern AG,Rebehmed J

更新日期：2013-08-01 00:00:00

abstract：:Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

journal_title：Amino acids

authors： Gopal R,Seo CH,Song PI,Park Y

更新日期：2013-02-01 00:00:00

abstract：:In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

journal_title：Amino acids

authors： Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

更新日期：2010-11-01 00:00:00

abstract：:O-linked β-N-actylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in a variety of cellular processes. O-GlcNAc was termed a nut...

journal_title：Amino acids

authors： Ma Z,Vosseller K

更新日期：2013-10-01 00:00:00

abstract：:D-Aspartate (D-Asp) is an endogenous substance in mammals. Degradation of D-Asp is carried out only by D-aspartate oxidase (DDO). We measured DDO activity in porcine tissues, and produced an anti-porcine DDO antibody to examine the cellular localization of DDO. All the tissues examined showed DDO activities, whereas t...

journal_title：Amino acids

authors： Yamamoto A,Tanaka H,Ishida T,Horiike K

更新日期：2011-07-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:An aromatic chiral diacid monomer, 5-[4-(2-phthalimidiylpropanoylamino)-benzoylamino]isophthalic acid was synthesized in five steps under conventional heating in high yield and purity. A series of soluble, thermally stable and optically active polyamides (PA)s containing pendent groups made of phthalimide, flexible L:...

journal_title：Amino acids

authors： Mallakpour S,Rafiee Z

更新日期：2009-10-01 00:00:00

abstract：:Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors. However, there are discordant reports on the effects of metformin on endothelial function in T2DM. Our ...

journal_title：Amino acids

authors： Kruszelnicka O,Chyrchel B,Golay A,Surdacki A

更新日期：2015-09-01 00:00:00

abstract：:In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...

journal_title：Amino acids

authors： Tantini B,Pignatti C,Fattori M,Fiumana E,Facchini A,Stefanelli C,Caldarera CM,Pegg AE,Flamigni F

更新日期：2004-10-01 00:00:00

abstract：:Ornithine decarboxylase antizyme 1 (AZ1) is a major regulatory protein responsible for the regulation and degradation of ornithine decarboxylase (ODC). To better understand the role of AZ1 in polyamine metabolism and in modulating the response to anticancer polyamine analogues, a small interfering RNA strategy was use...

journal_title：Amino acids

authors： Fraser AV,Goodwin AC,Hacker-Prietz A,Sugar E,Woster PM,Casero RA Jr

更新日期：2012-02-01 00:00:00

abstract：:In the present study, we report the synthesis and biological evaluation of a series of new non-peptide PAR(1) mimetic receptor antagonists, based on conformational analysis of the S(42)FLLR(46) tethered ligand (TL) sequence of PAR(1). These compounds incorporate the key pharmacophore groups in the TL sequence, guanidy...

journal_title：Amino acids

authors： Androutsou ME,Saifeddine M,Hollenberg MD,Matsoukas J,Agelis G

更新日期：2010-04-01 00:00:00

abstract：:Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine tota...

journal_title：Amino acids

authors： Hill CA,Harris RC,Kim HJ,Harris BD,Sale C,Boobis LH,Kim CK,Wise JA

更新日期：2007-02-01 00:00:00

abstract：:The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...

journal_title：Amino acids

authors： Bittner S,Win T,Gupta R

更新日期：2005-06-01 00:00:00

abstract：:Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...

journal_title：Amino acids

authors： Cao Q,Liu S,Niu G,Chen K,Yan Y,Liu Z,Chen X

更新日期：2011-11-01 00:00:00

abstract：:In 3T3 cells temperatures higher than physiological stimulated amino acid transport activity in a dose-dependent manner up to 44 degrees C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested. The activities of both amino acid transport systems A and ASC were en...

journal_title：Amino acids

authors： Petronini PG,Caccamo AE,Alfieri RR,Bonelli MA,Borghetti AF

更新日期：2001-01-01 00:00:00

abstract：:Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in ...

journal_title：Amino acids

authors： Castell LM,Newsholme EA

更新日期：2001-01-01 00:00:00

abstract：:Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...

journal_title：Amino acids

authors： Civitavecchia A,Martelli G,Orena M,Rinaldi S

更新日期：2014-04-01 00:00:00

abstract：:3-Fluorotyrosine fluorescence is quenched effectively by phosphate ions not only by a dynamic but also by a static mechanism owing to H-bond complex formation in ground state. 3-Fluorotyrosine pKa values both in the ground and first excited state (8.3 and 4, respectively) are appreciably lower than those of tyrosine, ...

journal_title：Amino acids

authors： Vdovenko SI,Kolycheva MT,Gerus II,Kukhar VP

更新日期：1993-10-01 00:00:00

abstract：:The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...

journal_title：Amino acids

authors： Xu Y,Qiang X,Xing L,Wang H,Zhang J,Zhang F,Caliskan B,Wang M,Qiu Z

更新日期：2018-08-01 00:00:00

abstract：:Pyridoxamine (PM) has long been known to inhibit protein glycation via various mechanisms of action. One such mechanism involves the scavenging of carbonyl compounds with glycating ability. Despite the abundant literature on this topic, few quantitative kinetic studies on the processes involved have been reported. In ...

journal_title：Amino acids

authors： Adrover M,Vilanova B,Frau J,Muñoz F,Donoso J

更新日期：2009-03-01 00:00:00