Catabolism of native and oxidized low density lipoproteins: in vivo insights from small animal positron emission tomography studies.

abstract：:Spermine oxidase (SMO) was discovered much more recently than other enzymes involved in polyamine metabolism; this review summarizes 10 years of researches on this enzyme. Spermine oxidase (SMO) is a FAD-dependent enzyme that specifically oxidizes spermine (Spm) and plays a dominant role in the highly regulated mammal...

journal_title：Amino acids

authors： Cervelli M,Amendola R,Polticelli F,Mariottini P

更新日期：2012-02-01 00:00:00

abstract：:N-acetylaspartate (NAA), an acetylated derivative of L-aspartate (Asp), and N-acetylaspartylglutamate (NAAG), a derivative of NAA and L-glutamate (Glu), are synthesized by neurons in brain. However, neurons cannot catabolize either of these substances, and so their metabolism requires the participation of two other ce...

journal_title：Amino acids

authors： Baslow MH

更新日期：2010-11-01 00:00:00

abstract：:The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirop...

journal_title：Amino acids

authors： Yu L,Liu Z,Fang H,Zeng QL,Zhao YF

更新日期：2005-06-01 00:00:00

abstract：:This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...

journal_title：Amino acids

authors： Hou Y,Wang L,Yi D,Ding B,Yang Z,Li J,Chen X,Qiu Y,Wu G

更新日期：2013-09-01 00:00:00

abstract：:N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with...

journal_title：Amino acids

authors： Ekkati AR,Campanali AA,Abouelatta AI,Shamoun M,Kalapugama S,Kelley M,Kodanko JJ

更新日期：2010-03-01 00:00:00

abstract：:This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise...

journal_title：Amino acids

authors： Maroto-Sánchez B,Lopez-Torres O,Valtueña J,Benito PJ,Palacios G,Díaz-Martínez ÁE,González-Lamuño D,Zinellu A,González-Gross M,Carru C

更新日期：2019-02-01 00:00:00

abstract：:Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...

journal_title：Amino acids

authors： Piña-Zentella G,de la Rosa-Cuevas G,Vázquez-Meza H,Piña E,de Piña MZ

更新日期：2012-05-01 00:00:00

abstract：:Nitric oxide synthase (NOS) activities are responsible for the enzymatic conversion of L-arginine into NO and L-citrulline. Relatively low amounts of NO are produced in intestinal epithelial cells or are released from nerve endings. The effects of NO production are related to the maintenance of epithelial integrity an...

journal_title：Amino acids

authors： Guihot G,Guimbaud R,Bertrand V,Narcy-Lambare B,Couturier D,Duée PH,Chaussade S,Blachier F

更新日期：2000-01-01 00:00:00

abstract：:The objective of this study was to determine the dose as well as duration of exposure-dependent effects of L-alanyl-L-glutamine, arginine or taurine on polymorphonuclear neutrophil (PMN) free alpha-keto acid profiles and, in a parallel study, on PMN immune functions. Exogenous L-alanyl-L-glutamine significantly increa...

journal_title：Amino acids

authors： Mühling J,Nickolaus KA,Halabi M,Fuchs M,Krüll M,Engel J,Wolff M,Matejec R,Langefeld TW,Welters ID,Menges T,Dehne MG,Sablotzki A,Hempelmann G

更新日期：2005-11-01 00:00:00

abstract：:Taurine is a β-amino acid found in high concentrations in excitable tissues, including the heart. A significant reduction in myocardial taurine content leads to the development of a unique dilated, atrophic cardiomyopathy. One of the major functions of taurine in the heart is the regulation of the respiratory chain. H...

journal_title：Amino acids

authors： Schaffer SW,Shimada-Takaura K,Jong CJ,Ito T,Takahashi K

更新日期：2016-02-01 00:00:00

abstract：:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. T...

journal_title：Amino acids

authors： Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson A

更新日期：1999-01-01 00:00:00

abstract：:It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...

journal_title：Amino acids

authors： Lubec B,Szekeres T

更新日期：1994-02-01 00:00:00

abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...

journal_title：Amino acids

authors： Thorpe SR,Baynes JW

更新日期：2003-12-01 00:00:00

abstract：:In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

journal_title：Amino acids

authors： Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

更新日期：2010-11-01 00:00:00

abstract：:Synthesis and properties of a new fluorescent/fluorogenic substrate Ac-DEVD-AMAC for caspase-3 are reported. The substrate is obtained by conventional Fmoc-based solid phase peptide synthesis and its properties are investigated with regard to fluorescence, sensitivity, applicability and kinetic constants. A non-tradit...

journal_title：Amino acids

authors： Lozanov V,Ivanov IP,Benkova B,Mitev V

更新日期：2009-03-01 00:00:00

abstract：:No systematic approach to detect expression of differentiation-related elements was published so far. The undifferentiated N1E-115 neuroblastoma cell line was switched into a neuronal phenotype by DMSO treatment and used for proteomic experiments. We used two-dimensional gel electrophoresis followed by unambiguous mas...

journal_title：Amino acids

authors： Oh JE,Karlmark Raja K,Shin JH,Pollak A,Hengstschläger M,Lubec G

更新日期：2006-10-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:Arginine is a precursor of proteins and employed in urea synthesis. It is also the precursor of many other compounds, such as creatine, nitric oxide, polyamines, agmatine, proline. In this review, its transport and that of other basic amino acids are examined, along with its transformation into nitric oxide, agmatine ...

journal_title：Amino acids

authors： Grillo MA,Colombatto S

更新日期：2004-07-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...

journal_title：Amino acids

authors： Compagnone A,Bandino A,Meli F,Bravoco V,Cravanzola C,Parola M,Colombatto S

更新日期：2012-02-01 00:00:00

abstract：:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

journal_title：Amino acids

authors： Bachrach U,Wang YC

更新日期：2002-01-01 00:00:00

abstract：:The cellular amino acid composition of plant cells was analyzed. The callus of carrot (Daucus carota), leaves of Torenia fournieri and protocomb-like body of Cymbidium, s.p. were examined as examples of plant cells. The cellular amino acid compositions differed in the plant cells, but their basic patterns were quite s...

journal_title：Amino acids

authors： Sorimachi K,Okayasu T,Akimoto K,Niwa A

更新日期：2000-01-01 00:00:00

abstract：:In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...

journal_title：Amino acids

authors： Inbar E,Canepa GE,Carrillo C,Glaser F,Suter Grotemeyer M,Rentsch D,Zilberstein D,Pereira CA

更新日期：2012-01-01 00:00:00

abstract：:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...

journal_title：Amino acids

authors： Yamamoto K,Niwa A

更新日期：1996-09-01 00:00:00

abstract：:Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...

journal_title：Amino acids

authors： Costa Júnior JM,Rosa MR,Protzek AO,de Paula FM,Ferreira SM,Rezende LF,Vanzela EC,Zoppi CC,Silveira LR,Kettelhut IC,Boschero AC,de Oliveira CA,Carneiro EM

更新日期：2015-04-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:The purpose of the present study was to investigate the relationship between plasma carnitine concentration and body composition variation in relation to muscular and fat masses since there is no experimentally proved correlation between plasma carnitine and body masses. We used bioelectric impedance analysis (BIA), t...

journal_title：Amino acids

authors： Gatti R,De Palo CB,Spinella P,De Palo EF

更新日期：1998-01-01 00:00:00

abstract：:In the postgenomic era new technologies are emerging for global analysis of protein function. The introduction of active site-directed chemical probes for enzymatic activity profiling in complex mixtures, known as activity-based proteomics has greatly accelerated functional annotation of proteins. Here we review probe...

journal_title：Amino acids

authors： Schmidinger H,Hermetter A,Birner-Gruenberger R

更新日期：2006-06-01 00:00:00

abstract：:The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...

journal_title：Amino acids

authors： Bittner S,Win T,Gupta R

更新日期：2005-06-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) biosynthesis depended to a great extent on the biotransformation characterization of glutamate decarboxylase (GAD) and process conditions. In this paper, the enhancing effect of D101 macroporous adsorption resin (MAR) on the GABA production was investigated based on the whole-cell biotra...

journal_title：Amino acids

authors： Yang SY,Liu SM,Jiang M,Wang BS,Peng LH,Zeng C

更新日期：2020-05-01 00:00:00

abstract：:In the present study, we report the synthesis and biological evaluation of a series of new non-peptide PAR(1) mimetic receptor antagonists, based on conformational analysis of the S(42)FLLR(46) tethered ligand (TL) sequence of PAR(1). These compounds incorporate the key pharmacophore groups in the TL sequence, guanidy...

journal_title：Amino acids

authors： Androutsou ME,Saifeddine M,Hollenberg MD,Matsoukas J,Agelis G

更新日期：2010-04-01 00:00:00