Arginine revisited: minireview article.

abstract：:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...

journal_title：Amino acids

authors： Skolnick P

更新日期：2002-01-01 00:00:00

abstract：:The objective of this study was to determine the dose as well as duration of exposure-dependent effects of L-alanyl-L-glutamine, arginine or taurine on polymorphonuclear neutrophil (PMN) free alpha-keto acid profiles and, in a parallel study, on PMN immune functions. Exogenous L-alanyl-L-glutamine significantly increa...

journal_title：Amino acids

authors： Mühling J,Nickolaus KA,Halabi M,Fuchs M,Krüll M,Engel J,Wolff M,Matejec R,Langefeld TW,Welters ID,Menges T,Dehne MG,Sablotzki A,Hempelmann G

更新日期：2005-11-01 00:00:00

abstract：:For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

journal_title：Amino acids

authors： Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

更新日期：2019-11-01 00:00:00

abstract：:Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the me...

journal_title：Amino acids

authors： Suenaga R,Yamane H,Tomonaga S,Asechi M,Adachi N,Tsuneyoshi Y,Kurauchi I,Sato H,Denbow DM,Furuse M

更新日期：2008-06-01 00:00:00

abstract：:This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...

journal_title：Amino acids

authors： Hou Y,Wang L,Yi D,Ding B,Yang Z,Li J,Chen X,Qiu Y,Wu G

更新日期：2013-09-01 00:00:00

abstract：:It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...

journal_title：Amino acids

authors： Lubec B,Szekeres T

更新日期：1994-02-01 00:00:00

abstract：:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...

journal_title：Amino acids

authors： Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YC

更新日期：2015-06-01 00:00:00

abstract：:The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...

journal_title：Amino acids

authors： Khalily MP,Gerekçi S,Güleç EA,Özen C,Özçubukçu S

更新日期：2018-11-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...

journal_title：Amino acids

authors： Kuhn-Nentwig L,Willems J,Seebeck T,Shalaby T,Kaiser M,Nentwig W

更新日期：2011-01-01 00:00:00

abstract：:D-Aspartate (D-Asp) is an endogenous substance in mammals. Degradation of D-Asp is carried out only by D-aspartate oxidase (DDO). We measured DDO activity in porcine tissues, and produced an anti-porcine DDO antibody to examine the cellular localization of DDO. All the tissues examined showed DDO activities, whereas t...

journal_title：Amino acids

authors： Yamamoto A,Tanaka H,Ishida T,Horiike K

更新日期：2011-07-01 00:00:00

abstract：:Tryptophanase is and is perfectly inert to D-tryptophan under ordinary conditions. However, activity that can degrade D-tryptophan into indole is observed when tryptophanase is in highly concentrated diammoniumhydrogen phosphate solution. The reaction has been so far unknown in tryptophanase metabolic pathways. Here w...

journal_title：Amino acids

authors： Shimada A,Shishido H,Nakamura I

更新日期：1996-03-01 00:00:00

abstract：:Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellular...

journal_title：Amino acids

authors： Sahún I,Gallego X,Gratacòs M,Murtra P,Trullás R,Maldonado R,Estivill X,Dierssen M

更新日期：2007-11-01 00:00:00

abstract：:Numerous indolyl amino acids and their derivatives inhibited arginase activity. The inhibition was found to be non-competitive, - at least partly - allosteric, and independent on manganese ions in the active site, and it cannot be explained by the dissociation of arginase homotrimers. Indole alone is weakly inhibitory...

journal_title：Amino acids

authors： Hrabák A,Bajor T,Mészáros G

更新日期：2008-02-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...

journal_title：Amino acids

authors： Wester A,Devocelle M,Tallant EA,Chappell MC,Gallagher PE,Paradisi F

更新日期：2017-10-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Cell-penetrating peptides, a group of short peptides, can traverse cell membranes to enter cells and thus facilitate the uptake of various molecular cargoes. Thus, they have the potential to become powerful drug delivery systems. The correct identification of peptides as cell-penetrating or non-cell-penetrating would ...

journal_title：Amino acids

authors： Chen L,Chu C,Huang T,Kong X,Cai YD

更新日期：2015-07-01 00:00:00

abstract：:Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

journal_title：Amino acids

authors： Kanda-Nambu K,Yasuda Y,Tochikubo K

更新日期：2000-01-01 00:00:00

abstract：:The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...

journal_title：Amino acids

authors： Kokotos G,Martin V,Constantinou-Kokotou V,Gibbons WA

更新日期：1996-09-01 00:00:00

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...

journal_title：Amino acids

authors： Prakash A,Luthra PM

更新日期：2012-10-01 00:00:00

abstract：:The increased protein requirement of endurance athletes may be related to the need to replace exercise-induced oxidative losses, especially of the branched-chain amino acids (BCAA). However, it is unknown if non-essential amino acids (NEAA) influence the requirement for essential amino acids (EAA) during post-exercise...

journal_title：Amino acids

authors： Kato H,Volterman KA,West DWD,Suzuki K,Moore DR

更新日期：2018-12-01 00:00:00

abstract：:Synthesis and properties of a new fluorescent/fluorogenic substrate Ac-DEVD-AMAC for caspase-3 are reported. The substrate is obtained by conventional Fmoc-based solid phase peptide synthesis and its properties are investigated with regard to fluorescence, sensitivity, applicability and kinetic constants. A non-tradit...

journal_title：Amino acids

authors： Lozanov V,Ivanov IP,Benkova B,Mitev V

更新日期：2009-03-01 00:00:00

abstract：:Since the formulation of the concept of "proteomics" in 1995, a plethora of proteomic technologies have been developed in order to study proteomes of tissues, cells and organelles. The powerful new technologies enabled by proteomic approaches have lead to the application of these methods to an exponentially increasing...

journal_title：Amino acids

authors： Vercauteren FG,Arckens L,Quirion R

更新日期：2007-09-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put ...

journal_title：Amino acids

authors： Perna AF,Ingrosso D,De Santo NG

更新日期：2003-12-01 00:00:00

abstract：:Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and ...

journal_title：Amino acids

authors： Harro J

更新日期：2006-10-01 00:00:00

abstract：:The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...

journal_title：Amino acids

authors： Lewerenz J,Maher P,Methner A

更新日期：2012-01-01 00:00:00

abstract：:L-tryptophan is an essential amino acid in food, but is also widely used as a drug on the basis of several physiological actions. Lately, tryptophan's uses as a drug and as a food supplement have been discontinued in several countries due to its severe side-effects.In the present study, the distribution of tryptophan ...

journal_title：Amino acids

authors： Sainio EL,Närvänen S,Sainio P,Tuohimaa P

更新日期：1995-06-01 00:00:00

abstract：:Developmental changes in the levels of the excitatory amino acids L-glutamate (Glu) and L-Aspartate (Asp) and inhibitory amino acids glycine (Gly) and gamma-amino butyric acid (GABA), as well as taurine and its related amino acids L-methionine (Met), L-cysteine (Cys) and L-serine (Ser) in the brain and pectoralis musc...

journal_title：Amino acids

authors： Sato M,Tomonaga S,Denbow DM,Furuse M

更新日期：2009-02-01 00:00:00