Abstract：
:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the principal limitations (i.e., delayed onset and low efficacy) that appear to be inherent to these conventional agents. In this brief overview, I summarize two glutamate-based approaches to develop novel antidepressants. These distinct and (on a cellular level) seemingly diametric strategies may converge on intracellular pathways that are also impacted upon by chronic treatment with biogenic amine based agents.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Skolnick Pdoi
10.1007/s00726-001-0121-7subject
Has Abstractpub_date
2002-01-01 00:00:00pages
153-9issue
1-3eissn
0939-4451issn
1438-2199journal_volume
23pub_type
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