Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

abstract：:Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...

journal_title：Amino acids

authors： Mera A,de Lima MZT,Bernardes A,Garcia W,Muniz JRC

更新日期：2019-04-01 00:00:00

abstract：:The study was designed to investigate the effects of NMDA receptor agonist on the behavioral activity in rats with experimental hyperammonemia. The experiments were performed on adult male Wistar rats. Experimental hyperammonemia was induced by intraperitoneal injections of tioacetamide (TAA, 200 mg/kg) for three cons...

journal_title：Amino acids

authors： Fedosiewicz-Wasiluk M,Hoły ZZ,Wiśniewska RJ,Wiśniewski K

更新日期：2005-02-01 00:00:00

abstract：:Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in ...

journal_title：Amino acids

authors： Castell LM,Newsholme EA

更新日期：2001-01-01 00:00:00

abstract：:Free D-aspartate (D-Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D-Asp levels depends on the postnatal onset of D-aspartate oxidase (DDO) activity, the only enzyme able to selectively degrade this ...

journal_title：Amino acids

authors： Errico F,Napolitano F,Nisticò R,Usiello A

更新日期：2012-11-01 00:00:00

abstract：:Astrocytes are glial cells in the central nervous system (CNS) that play key roles in brain physiology, controlling processes, such as neurogenesis, brain energy metabolism and synaptic transmission. Recently, immune functions have also been demonstrated in astrocytes, influencing neuronal survival in the course of ne...

journal_title：Amino acids

authors： Burgos M,Fradejas N,Calvo S,Kang SU,Tranque P,Lubec G

更新日期：2011-02-01 00:00:00

abstract：:The kinetic mechanism of the transport catalyzed by the human glutamine/neutral amino acid transporter hASCT2 over-expressed in P. pastoris was determined in proteoliposomes by pseudo-bi-substrate kinetic analysis of the Na(+)-glutamineex/glutaminein transport reaction. A random simultaneous mechanism resulted from th...

journal_title：Amino acids

authors： Scalise M,Pochini L,Panni S,Pingitore P,Hedfalk K,Indiveri C

更新日期：2014-11-01 00:00:00

abstract：:Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...

journal_title：Amino acids

authors： Militante JD,Lombardini JB

更新日期：1998-01-01 00:00:00

abstract：:Neurofilaments (NFs) are integral constituents of the neuron playing a major role in brain development, maintenance, regeneration and the pattern of expression for NFs suggests their contribution to plasticity of the neuronal cytoskeleton and creating and maintaining neuronal architecture. Using immune-histochemical t...

journal_title：Amino acids

authors： Bajo M,Yoo BC,Cairns N,Gratzer M,Lubec G

更新日期：2001-01-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:D-Asp-containing proteins have been implicated in many aging-related diseases. To clarify the role of D-Asp-containing proteins in such diseases, we developed a screening system for these proteins using a D-aspartyl endopeptidase that specifically cleaves the proteins at the C-terminus. The digested proteins were dete...

journal_title：Amino acids

authors： Sakai-Kato K,Kinouchi T,Fujii N,Imai K,Utsunomiya-Tate N

更新日期：2009-01-01 00:00:00

abstract：:When considering protein phosphorylation in bacteria, phosphorylation of aspartic acid and histidine residues mediated by the two-component systems is the first to spring to mind. And yet other phosphorylation systems have been described in bacteria in the past 20 years including eukaryotic-like serine/threonine kinas...

journal_title：Amino acids

authors： Bechet E,Guiral S,Torres S,Mijakovic I,Cozzone AJ,Grangeasse C

更新日期：2009-09-01 00:00:00

abstract：:There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application...

journal_title：Amino acids

authors： Gualano B,Roschel H,Lancha AH Jr,Brightbill CE,Rawson ES

更新日期：2012-08-01 00:00:00

abstract：:Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

journal_title：Amino acids

authors： Kanda-Nambu K,Yasuda Y,Tochikubo K

更新日期：2000-01-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:Oxidative stress, an excess of reactive oxygen species (ROS), may lead to oxidative post-translational modifications of proteins resulting in the cleavage of the peptide backbone, known as α-amidation, and formation of fragments such as peptide amides and α-ketoacyl peptides (α-KaP). In this study, we first compared d...

journal_title：Amino acids

authors： Sajapin J,Hellwig M

更新日期：2020-10-01 00:00:00

abstract：:The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...

journal_title：Amino acids

authors： Bittner S,Win T,Gupta R

更新日期：2005-06-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00

abstract：:Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the me...

journal_title：Amino acids

authors： Suenaga R,Yamane H,Tomonaga S,Asechi M,Adachi N,Tsuneyoshi Y,Kurauchi I,Sato H,Denbow DM,Furuse M

更新日期：2008-06-01 00:00:00

abstract：:Recently agmatine, decarboxylated arginine, has been shown to be an important biological compound in several animal tissues. This paper summarizes the known information regarding the transport of arginine, its decarboxylation and the effects of the agmatine formed mainly on NO and polyamine synthesis. ...

journal_title：Amino acids

authors： Grillo MA,Colombatto S

更新日期：2004-02-01 00:00:00

abstract：:We describe six children with tetrahydrobiopterin (BH(4)) responsive phenylalanine hydroxylase (PAH) deficiency. All patients carry two mutant alleles in the PAH gene. Cofactor deficiency was excluded. The effect of BH(4) administration was studied by correlating different oral BH(4) doses with plasma phenylalanine le...

journal_title：Amino acids

authors： Steinfeld R,Kohlschütter A,Ullrich K,Lukacs Z

更新日期：2003-07-01 00:00:00

abstract：:The focus has been on the development of methodology for stereoselective preparation of spiroannulated intermediates of the Schöllkopf chiron and further transformations to cyclic alpha-amino acids. The spiroannulations are effected by Ru(II)-catalysed ring-closing metathesis reactions, by Ru(II)- and Pd(0)-catalysed ...

journal_title：Amino acids

authors： Undheim K

更新日期：2008-04-01 00:00:00

abstract：:Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...

journal_title：Amino acids

authors： Reiken SR,Briedis DM

更新日期：1992-10-01 00:00:00

abstract：:Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...

journal_title：Amino acids

authors： Li H,Meininger CJ,Bazer FW,Wu G

更新日期：2016-10-01 00:00:00

abstract：:Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...

journal_title：Amino acids

authors： Costa Júnior JM,Rosa MR,Protzek AO,de Paula FM,Ferreira SM,Rezende LF,Vanzela EC,Zoppi CC,Silveira LR,Kettelhut IC,Boschero AC,de Oliveira CA,Carneiro EM

更新日期：2015-04-01 00:00:00

abstract：:We have been studying control mechanisms of gene expression in early embryogenesis in a South African clawed toad Xenopus laevis, especially during the period of midblastula transition (MBT), or the transition from the phase of active cell division (cleavage stage) to the phase of extensive morphogenesis (post-blastul...

journal_title：Amino acids

authors： Shiokawa K,Aso M,Kondo T,Takai J,Yoshida J,Mishina T,Fuchimukai K,Ogasawara T,Kariya T,Tashiro K,Igarashi K

更新日期：2010-02-01 00:00:00

abstract：:Transglutaminases (TGs) are a large family of related and ubiquitous enzymes that catalyze the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. Considerable and intense progress has been made in the understanding of the chemistry, molecular biol...

journal_title：Amino acids

authors： Tabolacci C,Lentini A,Provenzano B,Beninati S

更新日期：2012-02-01 00:00:00

abstract：:Several new beta,beta-dihalo and beta-halo-beta-substituted dehydroalanines and dehydrodipeptides were synthesized by reacting the corresponding dehydroamino acid derivative with a N-halosuccinimide or in the case of beta,beta-di-iododehydroalanines with iodine. The results obtained confirmed that the stereochemical o...

journal_title：Amino acids

authors： Ferreira PM,Monteiro LS,Pereira G

更新日期：2010-07-01 00:00:00

abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

journal_title：Amino acids

authors： Declerck V,Aitken DJ

更新日期：2011-08-01 00:00:00

abstract：:To mutant ddY/DAO(-) mice lacking D-amino-acid oxidase activity and normal ddY/DAO(+) mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pin...

journal_title：Amino acids

authors： Morikawa A,Hamase K,Inoue T,Konno R,Zaitsu K

更新日期：2007-01-01 00:00:00

abstract：:In the article (Romek et al. 2013) we reported the values of δ15N (‰) and δ13C (‰) obtained by. ...

journal_title：Amino acids

authors： Romek KM,Julien M,Frasquet-Darrieux M,Tea I,Antheaume I,Hankard R,Robins RJ

更新日期：2018-01-01 00:00:00