Abstract:
:Free D-aspartate (D-Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D-Asp levels depends on the postnatal onset of D-aspartate oxidase (DDO) activity, the only enzyme able to selectively degrade this D-amino acid. Several results indicate that D-Asp binds and activates N-methyl-D-aspartate receptors (NMDARs). Accordingly, recent studies have demonstrated that deregulated, higher levels of D-Asp, in knockout mice for Ddo gene and in D-Asp-treated mice, modulate hippocampal NMDAR-dependent long-term potentiation (LTP) and spatial memory. Moreover, similarly to D-serine, administration of D-Asp to old mice is able to rescue the physiological age-related decay of hippocampal LTP. In agreement with a neuromodulatory action of D-Asp on NMDARs, increased levels of this D-amino acid completely suppress long-term depression at corticostriatal synapses and attenuate the prepulse inhibition deficits produced in mice by the psychotomimetic drugs, amphetamine and MK-801. Based on the evidence which points to the ability of D-Asp to act as an endogenous agonist on NMDARs and considering the abundance of D-Asp during prenatal and early life, future studies will be crucial to address the effect of this molecule in the developmental processes of the brain controlled by the activation of NMDARs.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Errico F,Napolitano F,Nisticò R,Usiello Adoi
10.1007/s00726-012-1356-1subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1861-71issue
5eissn
0939-4451issn
1438-2199journal_volume
43pub_type
杂志文章,评审相关文献
AMINO ACIDS文献大全abstract::Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and pathophysiological processes including stress regulation, as well as affective and anxiety-related behaviour. Consistent with these functions, SP and its preferred neurokinin 1 ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-006-0335-9
更新日期:2006-10-01 00:00:00
abstract::eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0985-0
更新日期:2012-02-01 00:00:00
abstract::Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1940-2
更新日期:2015-05-01 00:00:00
abstract::Formalin-fixed paraffin-embedded (FFPE) tissues are a real treasure for retrospective analysis considering the amount of samples present in hospital archives, combined with pathological, clinical, and outcome information available for every sample. Although unlocking the proteome of these tissues is still a challenge,...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1494-0
更新日期:2013-08-01 00:00:00
abstract::Arginine is a precursor of proteins and employed in urea synthesis. It is also the precursor of many other compounds, such as creatine, nitric oxide, polyamines, agmatine, proline. In this review, its transport and that of other basic amino acids are examined, along with its transformation into nitric oxide, agmatine ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-004-0081-9
更新日期:2004-07-01 00:00:00
abstract::Anti-tissue transglutaminase (tTG) antibodies are specifically produced in the small-intestinal mucosa of celiac disease (CD) patients. It is now recognized that these antibodies, acting on cell-surface tTG, may play an active role in CD pathogenesis triggering an intracellular response via the activation of different...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1120-y
更新日期:2013-01-01 00:00:00
abstract::Polyamines, oxidized by serum amine oxidase, yield aminoaldehydes and hydrogen peroxide. Acrolein may be formed from the aminoaldehydes by a spontaneous beta-elimination process. These oxidation products "oxidized polyamines" inhibit bacterial growth and exhibit anticancer activity. The antimicrobial activity of oxidi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-007-0535-y
更新日期:2007-08-01 00:00:00
abstract::Taurine is a β-amino acid found in high concentrations in excitable tissues, including the heart. A significant reduction in myocardial taurine content leads to the development of a unique dilated, atrophic cardiomyopathy. One of the major functions of taurine in the heart is the regulation of the respiratory chain. H...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2110-2
更新日期:2016-02-01 00:00:00
abstract::Detailed knowledge of the composition of protein complexes is crucial for the understanding of their structure and function; however, appropriate techniques for compositional analyses of complexes largely rely on elaborate tagging, immunoprecipitation, cross-linking and purification strategies. The proteasome is a pro...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1296-9
更新日期:2012-09-01 00:00:00
abstract::This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02769-4
更新日期:2019-09-01 00:00:00
abstract::Involvement of individual antioxidant proteins (AOXP) and antioxidants in the differentiation process has been already reported. A systematic search strategy for detecting differentially regulated AOXP in neuronal differentiation, however, has not been published so far. The aim of this study was to provide an analytic...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0214-9
更新日期:2005-11-01 00:00:00
abstract::Isoprostanes, non-enzymatic peroxidation products of arachidonic acid, are attractive biomarkers of oxidative stress in research in biology, medicine and nutrition. For the appropriate use of biomarkers it is required that these are both biologically and technically valid. Whereas the biological validity of isoprostan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0229-2
更新日期:2005-12-01 00:00:00
abstract::Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/BF01388176
更新日期:1999-01-01 00:00:00
abstract::Nitric oxide synthase (NOS) activities are responsible for the enzymatic conversion of L-arginine into NO and L-citrulline. Relatively low amounts of NO are produced in intestinal epithelial cells or are released from nerve endings. The effects of NO production are related to the maintenance of epithelial integrity an...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260050020
更新日期:2000-01-01 00:00:00
abstract::A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2364-3
更新日期:2017-02-01 00:00:00
abstract::The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1605-y
更新日期:2014-03-01 00:00:00
abstract::Developmental changes in the levels of the excitatory amino acids L-glutamate (Glu) and L-Aspartate (Asp) and inhibitory amino acids glycine (Gly) and gamma-amino butyric acid (GABA), as well as taurine and its related amino acids L-methionine (Met), L-cysteine (Cys) and L-serine (Ser) in the brain and pectoralis musc...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0068-z
更新日期:2009-02-01 00:00:00
abstract::We studied in vivo production of taurine, hypotaurine and sulfate following subcutaneous administration of L-cysteinesulfinate (CSA) to rats and mice. When 5.0 mmol/kg of body weight of CSA was injected to rats, increased urinary excretions of taurine, hypotaurine and sulfate in 24 h urine were 617, 52 and 1,767 micro...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0277-7
更新日期:2006-07-01 00:00:00
abstract::We examined the effects of DON [glutamine-analogue and inhibitor of glutamine-requiring enzymes], alanyl-glutamine (regarding its role in neutrophil immunonutrition) and alanyl-glutamine combined with L-NAME, SNAP, DON, beta-alanine and DFMO on neutrophil amino and alpha-keto acid concentrations or important neutrophi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-006-0395-x
更新日期:2007-09-01 00:00:00
abstract::Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide,...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-006-0477-9
更新日期:2007-11-01 00:00:00
abstract::Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2183-6
更新日期:2016-08-01 00:00:00
abstract::Treatment of developing rats with monosodium glutamate (MSG) produces an increase of glutamate levels in the brain, being this elevation dependent on both route of administration and animal's age. The capacity of exogenous MSG to induce convulsions seems to be related to the rate of glutamate elevation in the brain, r...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00808094
更新日期:1991-02-01 00:00:00
abstract::The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-005-0196-7
更新日期:2005-06-01 00:00:00
abstract::Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0548-9
更新日期:2011-11-01 00:00:00
abstract::Cu(I)-mediated [3+2]cycloaddition between azides and alkynes has evolved into a valuable bioconjugation tool in radiopharmaceutical chemistry. We have developed a simple, convenient and reliable radiosynthesis of 4-[18F]fluoro-N-methyl-N-(propyl-2-yn-1-yl)benzenesulfonamide ([18F]F-SA) as a novel aromatic sulfonamide-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1450-4
更新日期:2013-04-01 00:00:00
abstract::We describe six children with tetrahydrobiopterin (BH(4)) responsive phenylalanine hydroxylase (PAH) deficiency. All patients carry two mutant alleles in the PAH gene. Cofactor deficiency was excluded. The effect of BH(4) administration was studied by correlating different oral BH(4) doses with plasma phenylalanine le...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-002-0354-0
更新日期:2003-07-01 00:00:00
abstract::Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2029-7
更新日期:2015-11-01 00:00:00
abstract::Oral β-alanine (βA) doses larger than 800 mg commonly result in unpleasant sensory symptoms (paresthesia). However, the association of form (pure vs. slow-release) with side-effects has not been fully described. The aim of this single-blinded, randomized three-arm clinical trial was to compare plasma kinetics and symp...
journal_title:Amino acids
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00726-011-1169-7
更新日期:2012-07-01 00:00:00
abstract::Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1517-x
更新日期:2014-03-01 00:00:00
abstract::In this paper we report the complete separation of amino acids as DABS-derivatives using a 3µm Supelcosil LC-18 (25 cm × 2.1 mm I.D.) narrowbore column. The system described makes it possible to perform the analysis of DABS-amino acids with a sensitivity to the femtomole level. We have also studied the conditions nece...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00806005
更新日期:1992-10-01 00:00:00