Monosodium glutamate induced convulsions in rats: Influence of route of administration, temperature and age.

abstract：:This mini review deals with the modern aspects of the spectroscopy and structural elucidation of amino acid derivatives and small biologically active compounds. Free peptide bond rotation in these systems yields various conformers, which possess differing biological activities. Another phenomenon is the intermolecular...

journal_title：Amino acids

authors： Kolev T,Spiteller M,Koleva B

更新日期：2010-01-01 00:00:00

abstract：:Glutaryl-CoA dehydrogenase deficiency (GDD), which is one of the most frequent organic acid disorders, is characterized by a specific age- and regional-dependent neuropathology. We hypothesized that the distinct brain damage in GDD could be caused by the main pathologic metabolites, the organic acids glutaric (GA) and...

journal_title：Amino acids

authors： Kölker S,Ahlemeyer B,Krieglstein J,Hoffmann GF

更新日期：2000-01-01 00:00:00

abstract：:The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...

journal_title：Amino acids

authors： Benfodda Z,Bénimélis D,Reginato G,Meffre P

更新日期：2015-02-01 00:00:00

abstract：:The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...

journal_title：Amino acids

authors： Suryawan A,O'Connor PM,Bush JA,Nguyen HV,Davis TA

更新日期：2009-05-01 00:00:00

abstract：:The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via su...

journal_title：Amino acids

authors： Brosnan ME,Brosnan JT

更新日期：2016-08-01 00:00:00

abstract：:The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functi...

journal_title：Amino acids

authors： Zanelli CF,Valentini SR

更新日期：2007-08-01 00:00:00

abstract：:We examined the effects of DON [glutamine-analogue and inhibitor of glutamine-requiring enzymes], alanyl-glutamine (regarding its role in neutrophil immunonutrition) and alanyl-glutamine combined with L-NAME, SNAP, DON, beta-alanine and DFMO on neutrophil amino and alpha-keto acid concentrations or important neutrophi...

journal_title：Amino acids

authors： Mühling J,Burchert D,Langefeld TW,Matejec R,Harbach H,Engel J,Wolff M,Welters ID,Fuchs M,Menges T,Krüll M,Hempelmann G

更新日期：2007-09-01 00:00:00

abstract：:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophe...

journal_title：Amino acids

authors： Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri K

更新日期：2007-01-01 00:00:00

abstract：:Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524-1548)-RAD51(241-260) complex...

journal_title：Amino acids

authors： Li J,Lu K,Lv M,Liu G,Ma L,Qi J

更新日期：2020-03-01 00:00:00

abstract：:Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...

journal_title：Amino acids

authors： Liu Y,Li YB,Gao X,Yu YF,Liu XX,Ji ZL,Ma Y,Li YM,Zhao YF

更新日期：2018-01-01 00:00:00

abstract：:The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placeb...

journal_title：Amino acids

authors： Van Brummelen R,du Toit D

更新日期：2007-07-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:Minerals more readily adsorb amino acids with charged R groups than uncharged R groups, so that the incorporation of amino acids with charged R groups into peptides would be more frequent than for amino acids with uncharged R groups. However, 74% of the amino acids in the proteins of modern organisms contain uncharged...

journal_title：Amino acids

authors： Zaia DA

更新日期：2004-08-01 00:00:00

abstract：:In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied dis...

journal_title：Amino acids

authors： Martínez V,Sánchez L,Busquets MA,Infante MR,Pilar Vinardell M,Mitjans M

更新日期：2007-09-01 00:00:00

abstract：:Synthesis and properties of a new fluorescent/fluorogenic substrate Ac-DEVD-AMAC for caspase-3 are reported. The substrate is obtained by conventional Fmoc-based solid phase peptide synthesis and its properties are investigated with regard to fluorescence, sensitivity, applicability and kinetic constants. A non-tradit...

journal_title：Amino acids

authors： Lozanov V,Ivanov IP,Benkova B,Mitev V

更新日期：2009-03-01 00:00:00

abstract：:Nitric oxide (NO) is a free radical gas synthesised from arginine and oxygen by enzymes of the family of the nitric oxide synthase. In particular, the neuronal nitric oxide synthase (nNOS) is highly expressed by cells of the hypothalamic paraventricular nucleus, where the sympatho-adrenal system, the hypothalamic-pitu...

journal_title：Amino acids

authors： Orlando GF,Wolf G,Engelmann M

更新日期：2008-06-01 00:00:00

abstract：:Lamin A/C proteins are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations in the lamin A/C gene cause a disease with remarkably different clinical features: FPLD, or familial partial lipodystrophy (Dunnigan-type), which mai...

journal_title：Amino acids

authors： Rajendran V,Purohit R,Sethumadhavan R

更新日期：2012-08-01 00:00:00

abstract：:The nucleotide (ATP-ADP)/nucleoside (adenosine) ratio in the circulation can modulate the processes of vasoconstriction, vasodilatation and platelet aggregation. The main objective of the present study with rat blood serum was to evaluate the possibility of changes in nucleotide hydrolysis by phenylalanine (Phe) and p...

journal_title：Amino acids

authors： Rücker B,Oses JP,Kirst IB,Berti SL,Bonan CD,Battastini AM,Sarkis JJ

更新日期：2003-06-01 00:00:00

abstract：:Recently agmatine, decarboxylated arginine, has been shown to be an important biological compound in several animal tissues. This paper summarizes the known information regarding the transport of arginine, its decarboxylation and the effects of the agmatine formed mainly on NO and polyamine synthesis. ...

journal_title：Amino acids

authors： Grillo MA,Colombatto S

更新日期：2004-02-01 00:00:00

abstract：:Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...

journal_title：Amino acids

authors： Bodnar M,Luczak M,Bednarek K,Szylberg L,Marszalek A,Grenman R,Szyfter K,Jarmuz-Szymczak M,Giefing M

更新日期：2016-06-01 00:00:00

abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

journal_title：Amino acids

authors： Declerck V,Aitken DJ

更新日期：2011-08-01 00:00:00

abstract：:Glioma is the most common type of brain tumor, and has the worst prognosis in human malignancy. Experimental evidence suggests that the use of high concentrations of various amino acids may perturb neoplastic cell growth. Thus, the aim of this study was to investigate whether essential amino acids can alter the growth...

journal_title：Amino acids

authors： Takeuchi S,Nawashiro H,Wada K,Nomura N,Toyooka T,Otani N,Osada H,Matsuo H,Shinomiya N

更新日期：2012-08-01 00:00:00

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:Increased intracellular cysteine poses a potential danger to cells due to the high ability of cysteine to reduce free iron and promote the Fenton reaction. Here, we studied ways to maintain cysteine homeostasis in E. coli cells while inhibiting protein synthesis with valine or chloramphenicol. When growing wild-type b...

journal_title：Amino acids

authors： Smirnova GV,Tyulenev AV,Bezmaternykh KV,Muzyka NG,Ushakov VY,Oktyabrsky ON

更新日期：2019-11-01 00:00:00

abstract：:The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...

journal_title：Amino acids

authors： Ramkumar S,Fujii N,Sakaue H,Fujii N,Thankappan B,kumari RP,Natarajaseenivasan K,Anbarasu K

更新日期：2015-05-01 00:00:00

abstract：:In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism. Evidence for a physiological role in neuronal excitability has not been strong, in part because brain...

journal_title：Amino acids

authors： Scharfman HE,Goodman JH,Schwarcz R

更新日期：2000-01-01 00:00:00

abstract：:Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...

journal_title：Amino acids

authors： Djordjević BV,Pavlović R,Ćosić V,Deljanin-Ilić M,Ristić T,Krstić N,Jevtović-Stoimenov T

更新日期：2012-12-01 00:00:00

abstract：:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...

journal_title：Amino acids

authors： Skolnick P

更新日期：2002-01-01 00:00:00

abstract：:Effects of taurine on the delayed rectifier K(+) channel in isolated 10-day-old embryonic chick ventricular cardiomyocytes were examined at different intracellular Ca(2+) concentrations ([Ca]i), using whole-cell voltage and current clamp techniques. Experiments were performed at room temperature (22°C). Test pulses we...

journal_title：Amino acids

authors： Satoh H

更新日期：1995-09-01 00:00:00

abstract：:Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial lea...

journal_title：Amino acids

authors： Tan F,Feng X,Fang Z,Li M,Guo Y,Jiang L

更新日期：2007-11-01 00:00:00