Abstract:
:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophenylalanine derivative and aromatic diiodo (or dibromo) compounds.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri Kdoi
10.1007/s00726-006-0402-2subject
Has Abstractpub_date
2007-01-01 00:00:00pages
387-94issue
3eissn
0939-4451issn
1438-2199journal_volume
32pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::Glutaryl-CoA dehydrogenase deficiency (GDD), which is one of the most frequent organic acid disorders, is characterized by a specific age- and regional-dependent neuropathology. We hypothesized that the distinct brain damage in GDD could be caused by the main pathologic metabolites, the organic acids glutaric (GA) and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260050003
更新日期:2000-01-01 00:00:00
abstract::Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2588-5
更新日期:2018-08-01 00:00:00
abstract::3-Hydroxyaspartic acid and its derivatives are found both in the free form and as peptide constituents in various microorganisms and fungi. Considering the biological importance of this amino acid and its potential utility as a multifunctional building block in organic syntheses, we have developed a short-step, asymme...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-007-0595-z
更新日期:2008-08-01 00:00:00
abstract::Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805831
更新日期:1995-06-01 00:00:00
abstract::Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805989
更新日期:1993-06-01 00:00:00
abstract::Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1511-3
更新日期:2013-08-01 00:00:00
abstract::We report the solid phase synthesis and some pharmacological properties of 24 oxytocin (OT) analogues. Basic modifications at position 9 (introduction of L- or D-beta-(2-thienyl)-alanine [L- or D-Thi], or L- or D-3-Pyridylalanine [L- or D-3-Pal]) were combined with D-tyrosine(OEthyl) [D-Tyr(Et)] or D-1-naphthylalanine...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0372-2
更新日期:2010-05-01 00:00:00
abstract::L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02783-6
更新日期:2019-11-01 00:00:00
abstract::The sulfur-containing excitatory amino acid (EAA) L-cysteine sulfinic acid (CSA), a neurotransmitter candidate, is endogenously synthesized from L-cysteine (Cys). Exogenous Cys administration into the brain produces cardiovascular effects; these effects likely occur via synaptic stimulation of central nervous system (...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1733-z
更新日期:2014-07-01 00:00:00
abstract::On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-001-0121-7
更新日期:2002-01-01 00:00:00
abstract::Oral β-alanine (βA) doses larger than 800 mg commonly result in unpleasant sensory symptoms (paresthesia). However, the association of form (pure vs. slow-release) with side-effects has not been fully described. The aim of this single-blinded, randomized three-arm clinical trial was to compare plasma kinetics and symp...
journal_title:Amino acids
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00726-011-1169-7
更新日期:2012-07-01 00:00:00
abstract::Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1303-1
更新日期:2012-11-01 00:00:00
abstract::Developmental changes in the levels of the excitatory amino acids L-glutamate (Glu) and L-Aspartate (Asp) and inhibitory amino acids glycine (Gly) and gamma-amino butyric acid (GABA), as well as taurine and its related amino acids L-methionine (Met), L-cysteine (Cys) and L-serine (Ser) in the brain and pectoralis musc...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0068-z
更新日期:2009-02-01 00:00:00
abstract::Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1096-7
更新日期:2012-07-01 00:00:00
abstract::Nitrogen fixation of the nodule of soybean is highly sensitive to oxygen deficiency such as provoked by waterlogging of the root system. This study aimed to evaluate the effects of flooding on N metabolism in nodules of soybean. Flooding resulted in a marked decrease of asparagine (the most abundant amino acid) and a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2179-2
更新日期:2016-05-01 00:00:00
abstract::The intestine is not only critical for the absorption of nutrients, but also interacts with a complex external milieu. Most foreign antigens enter the body through the digestive tract. Dietary amino acids are major fuels for the small intestinal mucosa, as well as important substrates for syntheses of intestinal prote...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-008-0152-4
更新日期:2009-05-01 00:00:00
abstract::Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02720-7
更新日期:2020-02-01 00:00:00
abstract::Isoprostanes, non-enzymatic peroxidation products of arachidonic acid, are attractive biomarkers of oxidative stress in research in biology, medicine and nutrition. For the appropriate use of biomarkers it is required that these are both biologically and technically valid. Whereas the biological validity of isoprostan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0229-2
更新日期:2005-12-01 00:00:00
abstract::In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism. Evidence for a physiological role in neuronal excitability has not been strong, in part because brain...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s007260070060
更新日期:2000-01-01 00:00:00
abstract::Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2029-7
更新日期:2015-11-01 00:00:00
abstract::Reports on nucleobase-containing chiral peptides (both natural and artificial) and achiral pseudopeptides are reviewed. Their synthesis, structural features, DNA and RNA-binding ability, as well as some other interesting applications which make them promising diagnostic/therapeutic agents of great importance in many a...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-010-0567-6
更新日期:2010-06-01 00:00:00
abstract::Two experiments were conducted to evaluate the effects of dietary supplementation with Astragalus polysaccharide (APS) on growth performance, apparent ileal digestibilities (AID) of amino acids (AA), and their serum concentrations in early weaned piglets. In Exp. 1, 60 pigs were weaned at 21 days of age (BW 7.35 +/- 0...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0142-6
更新日期:2009-07-01 00:00:00
abstract::In this study, an optically active diamine, N,N'-(pyromellitoyl)-bis{N-[4(4-aminophenoxy)phenyl]-2-(4-methyl)pentanamide} (1) containing amino acid L-leucine was prepared in three steps. The step-growth polymerization of this chiral diamine with several diisocyanates in room temperature ionic liquid (IL), 1,3-dipropyl...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0660-x
更新日期:2011-02-01 00:00:00
abstract::Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium ph...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0359-z
更新日期:2010-05-01 00:00:00
abstract::Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1671-9
更新日期:2014-04-01 00:00:00
abstract::The study of nanomaterial/biomolecule interface is an important emerging field in bionanoscience, and additionally in many biological processes such as hard-tissue growth and cell-surface adhesion. To have a deeper understanding of the amino acids/gold nanoparticle assemblies, the adsorption of these amino acids on th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1642-6
更新日期:2014-04-01 00:00:00
abstract::The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1605-y
更新日期:2014-03-01 00:00:00
abstract::Formalin-fixed paraffin-embedded (FFPE) tissues are a real treasure for retrospective analysis considering the amount of samples present in hospital archives, combined with pathological, clinical, and outcome information available for every sample. Although unlocking the proteome of these tissues is still a challenge,...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1494-0
更新日期:2013-08-01 00:00:00
abstract::Excitotoxicity induced by NMDA receptor stimulation is able to increase the activity of many enzymes involved in neuronal cell death. Primary cultures of rat cerebellar granule cells were used to elucidate the role of transglutaminase reaction in the excitotoxic cell response, and to evaluate the role of glutamate rec...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-003-0007-y
更新日期:2004-03-01 00:00:00
abstract::It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00808453
更新日期:1994-02-01 00:00:00