Abstract:
:3-Hydroxyaspartic acid and its derivatives are found both in the free form and as peptide constituents in various microorganisms and fungi. Considering the biological importance of this amino acid and its potential utility as a multifunctional building block in organic syntheses, we have developed a short-step, asymmetric synthetic route to a strategically protected 3-hydroxyaspartic acid derivative in enantiopure form. The key steps in the synthesis involve, Sharpless asymmetric aminohydroxylation of commercially available trans-ethyl cinnamate, and, utilization of the phenyl group as a masked carboxylic acid synthon towards construction of the complete structural framework of the title compound.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Khalaf JK,Datta Adoi
10.1007/s00726-007-0595-zsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
507-10issue
2eissn
0939-4451issn
1438-2199journal_volume
35pub_type
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